DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sdk and csf3r

DIOPT Version :9

Sequence 1:	NP_001284756.1	Gene:	sdk / 31017	FlyBaseID:	FBgn0021764	Length:	2265	Species:	Drosophila melanogaster
Sequence 2:	XP_002938787.3	Gene:	csf3r / 100498116	XenbaseID:	XB-GENE-482176	Length:	824	Species:	Xenopus tropicalis

Alignment Length:	772	Identity:	162/772 - (20%)
Similarity:	253/772 - (32%)	Gaps:	232/772 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   514 GKDATISCRAVGS---PNPNITWIYNETQLVDISSRVQILESGDLLI------SNIRSVDAGLYI 569
            |...:.|| |||.   |              |::..||::...|...      |:::...:.:|.
Frog    39 GSPLSASC-AVGKQFCP--------------DVNQDVQVIWKLDRAFTPSKDYSDVQQNGSSIYF 88

  Fly   570 CVRANEAGSVKGEAY------LSVLVRTQI---IQPPVDTTVLLGLTAT---LQC--KVSSDPSV 620
              |:....|.....|      |.::.|.:|   ..||..|.:...|..|   |.|  ::.|||.:
Frog    89 --RSFNKTSAALSCYFKMDQGLQLMDRVEINAGYPPPKPTNLTCQLNVTDGRLVCSWQLGSDPLI 151

  Fly   621 PYN--IDWYREGQSSTPISNSQRIGVQADGQLEIQAVRASDVGSYACVVTSPG------------ 671
            ..|  :...|..:...|.     :|                 |:|.| |..||
Frog   152 KTNATLSIARTNEYCEPF-----VG-----------------GNYHC-VPQPGETSCTITRHQYH 193

  Fly   672 -----------GNETRAARLSVIELPFPPSNVKVER---------LPEPQQRSINVSWTPGFDGN 716
                       .||..:|..|.:.|. |.:.||::.         |..||...|.|.       .
Frog   194 LYKKHAVWITVQNELGSANSSYLCLT-PMNQVKLDPPVIKEAAPVLSRPQCVRILVK-------K 250

  Fly   717 SPISKFI-----IQRREVSELGPVPDPLLNWITELSNVSADQRWILLENLKAATVYQFRVSAVNR 776
            |....:|     ::.|:|.|        ..| ||...::.|...:...||...|.|.|::..:.|
Frog   251 SETGSYIDQWYQLRYRKVEE--------SQW-TETHPMTEDYEVLEYCNLFPTTRYHFQIRCIRR 306

  Fly   777 VGEGSPSEPSNVVEL--PQEAPSGPPVGFVGSARSMSEIITQ----WQPPLEEHRNGQILGYILR 835
            ..||..||..:...|  .:.||:|....:..|..:.|:..|:    |:...:|..|.:...||:.
Frog   307 YLEGYWSEWGSDTTLLTAESAPTGKVKTWWRSLEAKSDGPTKIQLLWKALKKEEANSENPWYIVG 371

  Fly   836 YRLFGYNNVPWSYQNITNEAQRN------------FLIQELITWKDYIVQIAAYNNMGVGVYTEG 888
            .||    :..|:...:.|....|            ||      |        .||.:|   ::..
Frog   372 IRL----DTDWNGNVVCNTTALNCSFHLPNGATGAFL------W--------VYNTVG---HSPR 415

  Fly   889 SKIK-TKEGVPEAPPTNVKVEAINSTAARCRWTPPNPQQINGINQGYKIQAWQRRLIDGEWR--- 949
            .:|. |...:|..|.:               |....|...:.:...:|:||..:..: .|||
Frog   416 MEIDFTNRRIPGKPVS---------------WIHVFPNTDHSLAVKWKLQAMAKSYV-LEWRKSS 464

  Fly   950 -----DIERRMKTVPPSLIDPLAEQTAILGGLEKFTEYNISVLCFTDPGDGVASSQVAVMTMDDV 1009
                 |...:.:|...|:        :||..:|.|.:|.:.|....:...| :..||...:....
Frog   465 QHPESDFNWKTETEGSSM--------SILQDIEPFQQYTVWVYPVYENQVG-SPVQVNAYSRQGA 520

  Fly  1010 PDEVTGLHFDDVSDRSVKVLW--APPRASNGILTGYTVRYQVKDRPDTLKSFNLTADDTELTVNQ 1072
            |:....|...||:..:..:.|  .|....:|.:|.||:.:...:| .|| |..|.:..|...:..
Frog   521 PEFAPKLTVLDVAKSAAYLSWESIPLEKRHGFITNYTIFWTDSNR-QTL-SATLNSSLTRFVIKN 583

  Fly  1073 LQATTHYWFEIVAWTRVGSGIPKTATIQSGVEPVLPHAPTALALSNIEAFSVVL----------- 1126
            ||....|..:|...|..||.......|.:          |.|....|....:||
Frog   584 LQPLAMYTVQISCSTAEGSVNGSVLMINT----------TLLDEMEIHILILVLCLLFATLIGSF 638

  Fly  1127 ------------QFTP--GFDGNSSITKWKVEGQTARNMTWFTICEINDPDAETLTV 1169
                        .|.|  ....|||:.||......:..|: |.|.|||......||:
Frog   639 FFCLGKQERVKNTFWPIVPDPANSSMGKWSPVLNESPKMS-FNIKEINQMITSDLTI 694

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdk	NP_001284756.1	Ig	71..157	CDD:299845
		I-set	72..150	CDD:254352
		Ig	172..245	CDD:299845
		IG_like	280..356	CDD:214653
		Ig	280..343	CDD:299845
		IG_like	375..450	CDD:214653
		Ig	378..447	CDD:143165
		Ig	506..587	CDD:299845	17/87 (20%)
		IG_like	506..587	CDD:214653	17/87 (20%)
		I-set	592..682	CDD:254352	24/122 (20%)
		Ig	595..682	CDD:299845	23/116 (20%)
		FN3	686..789	CDD:238020	27/116 (23%)
		FN3	798..893	CDD:238020	21/111 (19%)
		FN3	901..1005	CDD:238020	21/111 (19%)
		fn3	1011..1094	CDD:278470	22/84 (26%)
		FN3	1108..1202	CDD:238020	20/87 (23%)
		FN3	1210..1308	CDD:238020
		fn3	1317..1402	CDD:278470
		FN3	1415..1507	CDD:238020
		FN3	1513..1608	CDD:238020
		fn3	1617..1708	CDD:278470
		FN3	1722..1823	CDD:238020
		FN3	1828..1920	CDD:238020
		FN3	1927..2016	CDD:238020
csf3r	XP_002938787.3	Lep_receptor_Ig	24..109	CDD:399379	16/86 (19%)
		FN3	<261..320	CDD:238020	17/67 (25%)
		FN3	429..511	CDD:238020	19/106 (18%)
		FN3	521..602	CDD:214495	21/82 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910