DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sdk and kirrel1b

DIOPT Version :9

Sequence 1:	NP_001284756.1	Gene:	sdk / 31017	FlyBaseID:	FBgn0021764	Length:	2265	Species:	Drosophila melanogaster
Sequence 2:	XP_017212964.1	Gene:	kirrel1b / 100170816	ZFINID:	ZDB-GENE-070912-173	Length:	801	Species:	Danio rerio

Alignment Length:	976	Identity:	207/976 - (21%)
Similarity:	324/976 - (33%)	Gaps:	339/976 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   247 VHLNVSGDPYIEVAPEIIVRPQDVKVKVGTGVVELQCIA-NARPLHELETLWLKDGLAVETAGVR 310
            ||...||       |.....|.|..|.:|..|| |.|:. |...:.:    |.|||||:   |:.
Zfish    18 VHRVFSG-------PRFSQEPADQSVVIGERVV-LSCVVFNYTGIVQ----WTKDGLAL---GIG 67

  Fly   311 HTLNDPWNR------------TLALLQANSSHSGEYTCQ---VRLRSGGYPAVSASARLQILEPP 360
            ..|. .|.|            .|.:..|:.:....|.||   ..||       |..|:|.:|.||
Zfish    68 EDLR-AWPRYRVLRIMDVGQYNLEITSADLTDDSLYECQATEAALR-------SRRAKLTVLIPP 124

  Fly   361 ----LFFTPMRAETFGEFGGQVQLTCDVVG-EPTPQVKWFRNAESVD-AH----IESGRYTLNTD 415
                :..:|   |.....|....|||...| :|...::|:::...|: ||    :.|.|..:.|.
Zfish   125 DGPVIEGSP---EILLTAGTSFNLTCVSRGAKPMSTIEWYKDGIIVEGAHTSTEVLSDRKRVTTK 186

  Fly   416 NTLVIKKLILDDAAMFQCLAINEAGENSASTWLRVKTKTAKNRVKRLAQPRILRVRASHAGLGSE 480
            :.|.|:.:..|....|.|:|.|                        ||.|           ||..
Zfish   187 SFLEIQPMDTDTGRNFTCVASN------------------------LAAP-----------LGKR 216

  Fly   481 KGSESGSSDRRKEFRFASAPIMELPPQNVTALDGKDATISCRAVGSPNPNITWIYNETQLVDISS 545
                   |............|:.:.|::|  |:|:....:|:|..:| |.:.:.:.:..::...:
Zfish   217 -------STVTLNIHHPPTVILSIEPRSV--LEGERVKFTCQATANP-PIMGYRWAKGGVILDGA 271

  Fly   546 RVQILESGDLLISNIRSVDAGLYI----CVRANEAGSVKGEAYLSVLVRTQ----IIQPPVDTTV 602
            |..:.|:         :.|...:.    |:..|..||..    :|:||...    ::..|...||
Zfish   272 RESVFET---------TADHSFFTEPVSCLVFNAVGSTN----VSILVDVHFGPILVVEPRPVTV 323

  Fly   603 LLGLTATLQCKVSSDPSVPYNIDWYREGQSSTPISNSQRIGVQADGQLEIQAVRASDVGSYAC-- 665
            .:....||.||.|.:|  |..:.|.::| ||..:|||        .||.:::|..:|.|.|.|
Zfish   324 DVDSDVTLNCKWSGNP--PLTLTWTKKG-SSMVLSNS--------NQLFLKSVSQADAGQYVCKA 377

  Fly   666 VVTSPGGNETRAARLSVIELPFPPSNVKVERLPEPQQRSINVSWTPGFDGNSPISKFIIQRREVS 730
            :|...|..||... |:|...|...|        ||.|.::                    |.|..
Zfish   378 IVPRIGVGETEVT-LTVNGPPIISS--------EPIQYAV--------------------RGEKG 413

  Fly   731 EL------GPVPDPLLNWITELSNVSADQRWILLENLKAATVYQFRVSAVNRVGEGSPSEPSNVV 789
            |:      .|.||.:: |..: .||...:|..|||..                          .|
Zfish   414 EIKCYIASTPPPDKIV-WAWK-ENVWEKERGTLLERY--------------------------TV 450

  Fly   790 ELPQEAPSGPPVGFVGSARSMSEII-TQWQPPLEEHRNGQILGYILRYRLFGYNNVPWSYQNITN 853
            |..:.|..|   |.|.|..:::.:: ..:|..                    ||...|   |...
Zfish   451 EQSRPATQG---GAVLSTLTINNVMEADFQST--------------------YNCTAW---NAFG 489

  Fly   854 EAQRNFLIQELITWKDYIVQIAAYNNMGVGVYTEGS---------------------KIKTKEGV 897
            .......::|        ..||:.:.:.|||...||                     :..::.||
Zfish   490 PGTMIITLEE--------TDIASEDIVPVGVIAGGSVGSSILLLLLLFALIFYLYRQRKSSRRGV 546

  Fly   898 PEAPPTNVKVEAIN------------STAARC-----RWTPPNPQQINGINQGYKIQAWQRRLID 945
            ...|  ::|||.:|            |||.|.     .:.|  ...::...|.:|
Zfish   547 TLKP--DIKVETVNKETNLEEEAASASTATRMVKAMYSFLP--SVSLSPSTQPFK---------- 597

  Fly   946 GEWRDIERRMKTVPPSLIDPLAEQTAILGGLEKFTEYNISVLCFTDPGDGVASSQVAVMTMDDVP 1010
             :..|:::.::|   ..::|            |..||...     ||.:|..:  |...|.|:|.
Zfish   598 -DDMDLKQDLQT---ETLEP------------KVEEYEAK-----DPTNGYYN--VRATTHDEVR 639

  Fly  1011 DEVTGLHFDDVSDRSVKVLWAPPRASNGILTG--------YTVRYQVKDRPDTLKSFNLTAD-DT 1066
            .....|.:.:..        ||..||....||        .|.||:.  ||.:..:.|..|. :|
Zfish   640 SSTRSLLYQEFR--------APNPASVSASTGGPANIHPAPTGRYEA--RPTSRMAHNTYAHFNT 694

  Fly  1067 ELTVNQLQATTHYWFEIVAWTRVGSGIPKTATIQSGVEPVLPHAPTALALSNIEAFSVVLQFTPG 1131
            ....:|:|...:               |.:.|.....|..|..:...||..:. |:|...|:..|
Zfish   695 IARASQIQPPAN---------------PVSKTTDYPAERGLLESTNPLAFDSY-AYSTTPQYRLG 743

  Fly  1132 F 1132
            |
Zfish   744 F 744

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdk	NP_001284756.1	Ig	71..157	CDD:299845
		I-set	72..150	CDD:254352
		Ig	172..245	CDD:299845
		IG_like	280..356	CDD:214653	23/91 (25%)
		Ig	280..343	CDD:299845	20/78 (26%)
		IG_like	375..450	CDD:214653	20/80 (25%)
		Ig	378..447	CDD:143165	19/74 (26%)
		Ig	506..587	CDD:299845	15/84 (18%)
		IG_like	506..587	CDD:214653	15/84 (18%)
		I-set	592..682	CDD:254352	29/95 (31%)
		Ig	595..682	CDD:299845	29/88 (33%)
		FN3	686..789	CDD:238020	18/108 (17%)
		FN3	798..893	CDD:238020	17/116 (15%)
		FN3	901..1005	CDD:238020	22/120 (18%)
		fn3	1011..1094	CDD:278470	17/91 (19%)
		FN3	1108..1202	CDD:238020	7/25 (28%)
		FN3	1210..1308	CDD:238020
		fn3	1317..1402	CDD:278470
		FN3	1415..1507	CDD:238020
		FN3	1513..1608	CDD:238020
		fn3	1617..1708	CDD:278470
		FN3	1722..1823	CDD:238020
		FN3	1828..1920	CDD:238020
		FN3	1927..2016	CDD:238020
kirrel1b	XP_017212964.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900