DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sdk and nfasca

DIOPT Version :9

Sequence 1:	NP_001284756.1	Gene:	sdk / 31017	FlyBaseID:	FBgn0021764	Length:	2265	Species:	Drosophila melanogaster
Sequence 2:	XP_021335211.1	Gene:	nfasca / 100141490	ZFINID:	ZDB-GENE-080229-6	Length:	1379	Species:	Danio rerio

Alignment Length:	1315	Identity:	306/1315 - (23%)
Similarity:	500/1315 - (38%)	Gaps:	268/1315 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 AIEMPSQPKLASLLAVLVLLCYCDSCFFCYADANLQQQNSIVQQQQLQAPRFTTHPSSSGSIVSE 87
            |||:|..||:                                 ||:|:.|......|....||..
Zfish    25 AIEVPLDPKI---------------------------------QQELKQPPTIVKQSLKDYIVDP 56

  Fly    88 GSTKILQCHALGYPQPTYRWLKDG----------VPVGDFSSSQFYRFHSTRREDAGSYQCIARN 142
            ....|::|.|.|.|.||::|.::|          |.:...|.:...|......:..|.|||.|.|
Zfish    57 RDNIIIECEAKGNPVPTFQWRRNGKFFNVGKDPRVTMRSRSGTLEIRSSGKPEDYEGEYQCFASN 121

  Fly   143 DAGSIFSEKSDVVVAYMGIFENTTEGRLTVISGHPAIFDMPPIESIPVPSVMWQ----------- 196
            :.|:..|.|..:.|:...::.......:||..|.|.:....|...:|.|...|.
Zfish   122 NLGTAISNKILLRVSKSPLWPKEVLEPVTVREGSPLVLACNPPPGLPPPETFWMDSFIMPIAQDR 186

  Fly   197 ----------------SEDGPLNY--DIKYAFTHANQLIILSADENDRKGYRAKAINTQLGKEES 243
                            ::|...:|  :.::.|||..|         .:..|..|....:...|..
Zfish   187 RVSMGLNGDLFFSNVLAKDAKTDYSCNARFEFTHTIQ---------QKNPYTLKVQTMRNIPETQ 242

  Fly   244 SAFVHLNVSGDPYIEVAPEIIVRPQDVKVKVGTGVVELQCIANARPLHELETLWLKDGLAVETAG 308
            ..|:      .|....:.::::|.:::.         |:|||...|...:  .|.|.|..:.|..
Zfish   243 PTFL------SPTGLSSTKMVLRGEELL---------LECIAAGVPTPTI--TWSKRGGDLPTKK 290

  Fly   309 VRHTLNDPWNRTLALLQANSSHSGEYTCQVRLRSGGYPAVSASARLQILEPPLFF-TPMRAETFG 372
            ||   ...:::||.:|..:....|.|||....|.|   ::..:..:|:...|.:. .|:......
Zfish   291 VR---IGNFDKTLRILNVSEEDIGSYTCMASNRIG---SIRHTVEVQVKAAPFWLEKPINLVLAP 349

  Fly   373 EFGGQVQLTCDVVGEPTPQVKWFRNAESVDAHIES-GRYTLNTDNTLVIKKLILDDAAMFQCLAI 436
            :..|  :|.|...|.|.|.::|..|.|.:::.:.: .|..|  |:|::.:.:..:.:|::||.|.
Zfish   350 DESG--RLVCRANGSPKPTIQWLVNGEPIESSLPNPNRRVL--DDTIIFETVQFESSAVYQCNAS 410

  Fly   437 NEAGENSASTWLRVKTKTAKNRVKRLAQPRILRVRASHAGLGSEKGSESGSSDRRKEFRFASAPI 501
            ||.|...|:.::.|                                             ...||.
Zfish   411 NEHGYLLANAFVSV---------------------------------------------LDMAPR 430

  Fly   502 MELPPQN--VTALDGKDATISCRAVGSPNPNITWIYNETQLVDISSRVQILESGDLLISNIRSVD 564
            | |.|:|  :..::.....:.|...|||.|.:.|..|...........::..:|.|.|...|:.|
Zfish   431 M-LGPKNQLIKVIENNRTFLECPFFGSPLPLLRWFKNGLGSGLDGGHYRLYHNGTLEIKQARTED 494

  Fly   565 AGLYICVRANEAGSVKGEAYLSVLVRTQIIQPPVDTTVLLGLTATLQCKVSSDPSVPYNIDWYRE 629
            .|.|.||.:|..|.::.:..|.|...|:|::.|...|...|.|....|:|..|||:|..:.|.::
Zfish   495 QGTYTCVASNILGKMENQVRLEVKEPTRIVRAPEHKTEPRGTTVRFDCRVKHDPSLPATVTWLKD 559

  Fly   630 GQSSTPISNSQRIG--VQADGQLEIQAVRASDVGSYACVVTSPGGNETRAARLSVIE-------- 684
               ..|:|.|. ||  .:.|..|.|..|...|.|:|.|...:....:|.:|||:|.|
Zfish   560 ---EKPLSFSW-IGRLKKDDESLTIYNVNPDDGGTYTCTAKTEIDEDTASARLTVTENDSSSASN 620

  Fly   685 ------LPFPPSNVKVERLPEPQQRSINVSWTPGFDGNSPISKFIIQRREVS-ELGPVPD-PLLN 741
                  .|.||.:::   |.:|..||:.::|.||.:.|||::.|::|..|.. |.|...: .:.:
Zfish   621 RSASAGRPDPPQDLE---LSDPSARSVRLTWVPGNENNSPVTHFLVQFEEDRWEPGKWQNLSIYD 682

  Fly   742 WITELSNVSADQRWILLENLKAATVYQFRVSAVNRVGEGSPSEPSNVVELPQEAPSGPPVGFVGS 806
            |  .|::|:.        .|.....|||||.|:|.||:..||.||...:....:|...|.|..|.
Zfish   683 W--NLNSVNL--------QLSPFVNYQFRVIAINAVGQSQPSHPSARYQTSGASPDVVPSGLKGW 737

  Fly   807 ARSMSEIITQWQPPLEEHRNGQILGYILRYRLFGYNNVPWSYQNITNEAQRNFLIQELITWKDYI 871
            ....:.:...||......|||..|.|:|.:|   ..:....:.|||. |:...::....|:..|.
Zfish   738 GSKKNNMEITWQAMQNTERNGPNLRYVLSWR---RKDTEEEWNNITT-AKTKHVVHNTDTYVPYE 798

  Fly   872 VQIAAYNNMGVGVYTEGSKI--KTKEGVPEAPPTNVKVEAINSTAARCRWTPPNPQQINGINQGY 934
            ::|.|.|:.|.|  .|.:.:  .:.|..|.|.||:::|..||||.....|.|.....:||..:.|
Zfish   799 IKIQAVNDFGHG--PESNMVIGYSGEDKPSAAPTDLRVSKINSTKVNIHWEPVEQSSVNGEFKEY 861

  Fly   935 KIQAW-QRRLIDGEWRDIERRMKTVPPSLIDPLAEQTAILGGLEKFTEYNISVLCFTDPGDGVAS 998
            |:..| :..||.|    ::.....:...........:.||..|..:::|.:.::......:|..|
Zfish   862 KLYYWREASLIKG----LKVNKTKLHKGFFTTAEHPSGILTELYPYSKYKMYMVVANREHEGPQS 922

  Fly   999 SQVAVMTMD---DVPDEVTGLHFDDVSDRSVKVLWAPPRASNGILTGYTVRY------QVKDRPD 1054
            :.|...|.:   ..|.....|...||    |.:.|..|...||:|.|||::|      |..:|
Zfish   923 NTVEFYTKEGEPGAPKYFRILRHTDV----VHLKWDKPLEPNGVLIGYTLQYHTVNGTQAGER-- 981

  Fly  1055 TLKSFNLTADDTELTVNQLQATTHYWFEIVAWTRVGSGIPKTATIQSGVEPVLPHAPTALALSNI 1119
            .::||  ..:.||..:|.....|.:.|.:.|.|:||:|  :...::|      ||. |.....:.
Zfish   982 KVQSF--PPNVTEYVMNLPHRFTRFKFFLAARTQVGAG--EVYAVES------PHF-TNEGTPDT 1035

  Fly  1120 EAFSVVLQFTPG--FDGNSSITKWKVEGQTARNMTWFTICEINDPDAETLTVTGLVPFTQYRLRL 1182
            ::..|.:.||.|  |:    |....:...|..|.|.||      |:......|...|........
Zfish  1036 DSTVVAVNFTDGLMFE----IPPPPLPPSTDPNPTIFT------PEPTPPVPTTAAPTKPTTTTT 1090

  Fly  1183 SASNVVGSSKPSEATKDFQTIQARPKHPPFNVTVRAMSAQQLRVRWIPLQQTEWY---------- 1237
            :.:....:|..:..|....|          ..|..|.|.....||.:|.:..:|.
Zfish  1091 TTTTTTTTSTTTTTTTTTTT----------TTTTTAASTTVAPVRPVPPKTVDWKMLAPNVKIWN 1145

  Fly  1238 ----GNPRGYNISYK 1248
                .|....|:|:|
Zfish  1146 LTVDANNDNANVSWK 1160

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdk	NP_001284756.1	Ig	71..157	CDD:299845	25/95 (26%)
		I-set	72..150	CDD:254352	23/87 (26%)
		Ig	172..245	CDD:299845	16/101 (16%)
		IG_like	280..356	CDD:214653	20/75 (27%)
		Ig	280..343	CDD:299845	19/62 (31%)
		IG_like	375..450	CDD:214653	21/75 (28%)
		Ig	378..447	CDD:143165	20/69 (29%)
		Ig	506..587	CDD:299845	21/82 (26%)
		IG_like	506..587	CDD:214653	21/82 (26%)
		I-set	592..682	CDD:254352	29/91 (32%)
		Ig	595..682	CDD:299845	28/88 (32%)
		FN3	686..789	CDD:238020	35/104 (34%)
		FN3	798..893	CDD:238020	24/96 (25%)
		FN3	901..1005	CDD:238020	24/104 (23%)
		fn3	1011..1094	CDD:278470	27/88 (31%)
		FN3	1108..1202	CDD:238020	19/95 (20%)
		FN3	1210..1308	CDD:238020	11/53 (21%)
		fn3	1317..1402	CDD:278470
		FN3	1415..1507	CDD:238020
		FN3	1513..1608	CDD:238020
		fn3	1617..1708	CDD:278470
		FN3	1722..1823	CDD:238020
		FN3	1828..1920	CDD:238020
		FN3	1927..2016	CDD:238020
nfasca	XP_021335211.1	Ig_hNeurofascin_like	60..134	CDD:143283	21/73 (29%)
		Ig	139..231	CDD:325142	15/100 (15%)
		Ig	263..333	CDD:325142	21/86 (24%)
		Ig	351..425	CDD:325142	22/122 (18%)
		Ig	449..514	CDD:319273	18/64 (28%)
		I-set	522..610	CDD:254352	29/91 (32%)
		FN3	628..717	CDD:238020	33/101 (33%)
		fn3	731..813	CDD:306538	23/87 (26%)
		FN3	828..929	CDD:238020	24/104 (23%)
		FN3	934..1018	CDD:238020	28/93 (30%)
		FN3	1142..1211	CDD:328772	4/19 (21%)
		Bravo_FIGEY	1262..1355	CDD:316405
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910