DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sdk and il6st

DIOPT Version :9

Sequence 1:	NP_001284756.1	Gene:	sdk / 31017	FlyBaseID:	FBgn0021764	Length:	2265	Species:	Drosophila melanogaster
Sequence 2:	NP_001106976.1	Gene:	il6st / 100006778	ZFINID:	ZDB-GENE-080104-6	Length:	866	Species:	Danio rerio

Alignment Length:	878	Identity:	168/878 - (19%)
Similarity:	275/878 - (31%)	Gaps:	317/878 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly  1076 TTHYWFEIVAWTRVGSGIPKTATIQSGVEPVLPHAPTALALSNIEAFSVVLQFTPGFDGNSSITK 1140
            |:|:|..::.......|...:..::     :||.:.|.:.:.....|:.......|.:..|:..|
Zfish     3 TSHHWLLVLMLLHYAKGSNSSCVLK-----ILPDSKTKIPVELERNFTATCHLQGGSEFTSNDIK 62

  Fly  1141 WKVEGQTARNMTWFTIC-EINDPDAETLTVTGLVPFTQYRLRLSASNVVGSSKPSEATKDFQTIQ 1204
            |....:...::...|.. :||:              |...:.::.|..:|.....||:::..|..
Zfish    63 WSFSNKETTDILSKTFYHKINE--------------TSVSVTVNLSKNMGHMLMCEASRESLTYM 113

  Fly  1205 AR-----------PKHPPFNVTVRAMSAQQ-----LRVRW-----IPLQQTEW-----YGNPRGY 1243
            .:           |...|.|:|..|:..::     |...|     .||..|.:     .|... |
Zfish   114 GKCAYGIYLDAGYPPMKPKNLTCIALQRKKDISPDLNCYWEPGLRDPLLATNYTLYAQVGQDL-Y 177

  Fly  1244 NISYKQLVKTPGTIKYVPRSVVIEDHTANSHVLDSLEEWTLYEVKMNACNDVGCSKESDTAVERT 1308
            |.:.||         .:.||..:...|...|:  :|:.|.  |||    |.:|..:..:...:..
Zfish   178 NSTCKQ---------SLARSCTVNLSTYPVHM--TLKVWV--EVK----NSLGSERSDEHEYDSL 225

  Fly  1309 REAVPSYGPLDVQANATSSTTVVVQWGEVPRQHRNGQIDGYKVFYAAADRGQQVLH---KTIPNN 1370
            ....|:...::|:......|:.||:|        ...|:...:.:::|.|..||..   |.:|.|
Zfish   226 SLVKPNPPNVEVKVEEDFPTSFVVKW--------EYDIEDTTMRFSSAIRYCQVGSSDWKKVPEN 282

  Fly  1371 AT----FTTTLTELKKYVVYHVQVLA----YT----RLGNGALSTPPIRVQTFEDTPGVP----- 1418
            .|    .:..|..|:.|..|.||:.:    ||    ...|..:.||..|     :.| :|
Zfish   283 YTNVHITSYRLQSLEPYTEYVVQMRSIGEHYTIWSEWSSNVTVRTPEAR-----EFP-LPFLKCV 341

  Fly  1419 -----SNVSFPDVSLTMARIIWDVPVDPNGKILAYQVTYTLNGSA---------MLN--YSREFP 1467
                 .|.|..:.:|.:: |:...||..|||:..|.:..:.:..|         .||  ||.|.|
Zfish   342 ALCEVVNASLYEQTLDLS-ILTKPPVKANGKMCNYSLIISQDNQAFESHVIKADQLNQRYSLEVP 405

  Fly  1468 PSDRTFRATELLPGKYYSFSCTAQTRLGWGKIATALVYTTNNRERPQAPSVPQISRSQIQAHQIT 1532
            |.:..            |...||....| |...|.|....:|.|
Zfish   406 PEENA------------SIEITAFNSAG-GSPKTILFIPRSNDE--------------------- 436

  Fly  1533 FSWTPGRDGFAPLRYYTVEMRENEGR----WQPL----PERVDPSLSSFTAVGLRPYMTYQFRIQ 1589
            |.      |.|.:|::.     ::|:    |.||    |..:..|               ::.::
Zfish   437 FL------GVASMRWWV-----HDGKLHVEWGPLKQHPPHGIHIS---------------EYLLE 475

  Fly  1590 ATNDLGPSAFSRESVIVRTLPAAPAVGVGGLKVVPITTTSVRVQWSALETALWNGDASTGGYRIL 1654
            ..|:                                  ..|:.||
Zfish   476 WVNE----------------------------------KDVQPQW-------------------- 486

  Fly  1655 YQQLSDFPTALQSTPKTDVHGINENSVVLS-DLQQDRNYEIVVLP---------FNSQGPGPATP 1709
                       |..||      |.|:.:|: :|.:.:.|.|.|.|         ::.|...|.|.
Zfish   487 -----------QRVPK------NVNTTILNGNLAKYKQYNISVYPIYKFYYDGRWHFQAGTPVTK 534

  Fly  1710 PAAVYVGEAVPTGEPRAVDAAPISSTEVRLLWKPPKQSMQNGDILGYKIYYLVTYSPQALEPGRK 1774
            ||  ||.:..|...|...|... ....|.|:|:......:.|.|..|.|:|            |.
Zfish   535 PA--YVQQGAPEKGPTVTDTIS-KKNSVTLIWEEIPLDHRYGFIQNYTIFY------------RT 584

  Fly  1775 WEEEIEVVSATATSHSLVFLDKFTE--YRIQLLAFNPAGDGPRSAPITVKTLPGVPSAPLHLRFS 1837
            ...|.:.|...|..||.|..|..:|  |.:.::|...|| .........||:
Zfish   585 GNAEWQSVLVAANIHSYVLTDLVSERDYVVHIMASTEAG-SKNGTDFNFKTM------------- 635

  Fly  1838 DITMQSLEVTWDPPKFLNGEI--------LGYL 1862
                          ||.:||:        ||:|
Zfish   636 --------------KFADGEVEMIVVLVCLGFL 654

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdk	NP_001284756.1	Ig	71..157	CDD:299845
		I-set	72..150	CDD:254352
		Ig	172..245	CDD:299845
		IG_like	280..356	CDD:214653
		Ig	280..343	CDD:299845
		IG_like	375..450	CDD:214653
		Ig	378..447	CDD:143165
		Ig	506..587	CDD:299845
		IG_like	506..587	CDD:214653
		I-set	592..682	CDD:254352
		Ig	595..682	CDD:299845
		FN3	686..789	CDD:238020
		FN3	798..893	CDD:238020
		FN3	901..1005	CDD:238020
		fn3	1011..1094	CDD:278470	4/17 (24%)
		FN3	1108..1202	CDD:238020	15/94 (16%)
		FN3	1210..1308	CDD:238020	25/112 (22%)
		fn3	1317..1402	CDD:278470	23/99 (23%)
		FN3	1415..1507	CDD:238020	27/112 (24%)
		FN3	1513..1608	CDD:238020	11/102 (11%)
		fn3	1617..1708	CDD:278470	16/100 (16%)
		FN3	1722..1823	CDD:238020	23/102 (23%)
		FN3	1828..1920	CDD:238020	7/43 (16%)
		FN3	1927..2016	CDD:238020
il6st	NP_001106976.1	FN3	127..219	CDD:304408	26/109 (24%)
		FN3	230..327	CDD:238020	24/104 (23%)
		FN3	543..624	CDD:214495	24/94 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910