DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sdk and dscaml1

DIOPT Version :9

Sequence 1:	NP_001284756.1	Gene:	sdk / 31017	FlyBaseID:	FBgn0021764	Length:	2265	Species:	Drosophila melanogaster
Sequence 2:	XP_005157551.1	Gene:	dscaml1 / 100002762	-ID:	-	Length:	2158	Species:	Danio rerio

Alignment Length:	1840	Identity:	409/1840 - (22%)
Similarity:	640/1840 - (34%)	Gaps:	504/1840 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 VSEGSTKILQCHALGYPQPTYRWLKDGVPVGDFSSSQFYR------FHSTRREDAGSYQCIARND 143
            |..|.:..|.|.|.|||.||.||||||.|:.  :.|::.|      ....|.||:|:|.|...|.
Zfish   306 VQVGRSIELPCIASGYPNPTIRWLKDGRPLP--ADSRWTRRLTGLTISDLRLEDSGNYICEVTNS 368

  Fly   144 AGSIFSEKSDVVVAYMGIFENTTEGRLTVISGHPAIFDMPP----------------IESIPVPS 192
            .||                 ....|.|.||  .|....:.|                ::..|..:
Zfish   369 FGS-----------------KEVTGHLNVI--EPLRVTLSPKNLKTGISSTVILSCAVQGSPHFT 414

  Fly   193 VMWQSEDGPLNYDIKYAF--THANQLIILSADENDRKGYRAKAINTQLGKEESSAFVHLNVSGDP 255
            |.|.....|:..|..::.  .|...|.|.:|.:.....|:..|  |:.|:......:.|...|.|
Zfish   415 VSWFRNTEPIVPDQHFSIQGAHNETLFITAAQKRHSGAYQCFA--TRKGQTAQDFSIILLEDGTP 477

  Fly   256 YIEVA-PEIIVRPQDVKVKVGTGVVELQCIANARP-----------------LHELETLWLKDGL 302
            .|..: .|.:|.|.:        ...|.|.|...|                 .|......|.||.
Zfish   478 RIVSSFSERVVAPGE--------PFSLMCAAKGAPPPTITWTLDDEPVARDSAHRASQYTLSDGS 534

  Fly   303 AVETAGVRHTLNDPWNRTLALLQA---NSSHSGEYTCQVRLRSGGYPAVSASARLQILEPPLFFT 364
            .|....|    .:|..|...:.:.   ||:.|.||..::.:|  |.|::.|...:..:.
Zfish   535 TVSHVNV----TNPQIRDGGVYRCAARNSAGSAEYQARINVR--GPPSIRAMRNITAVA------ 587

  Fly   365 PMRAETFGEFGGQVQLTCDVVGEPTPQVKWFRNAESV-DAHIESGRYTLNTDNTLVIKKLI--LD 426
                      |....:.|.|:|.|...:||:::...: |.|    |..:..:.||.:..:.  :|
Zfish   588 ----------GRNTFINCRVIGYPYYSIKWYKDGMLLPDNH----RQVVYENGTLKLSDVQKGMD 638

  Fly   427 DAAMFQCLAINEAGENSASTWLRVKTKTAKNRVKRLAQP-------------------------- 465
            :.|....:.|......|.:.::.||       |..|.||
Zfish   639 EGAYLCSVLIQPQLSISQTVYVTVK-------VPPLIQPFDFPPTSIGKLMYIACVVSSGDMPIR 696

  Fly   466 ----------------------------RILRVRASHAG----LGSEKGSESGSSDRRKEFRFAS 498
                                        :|.:|...|.|    :.|   :::.:....::.....
Zfish   697 ITWRKDGQEIVSGTAGVTIETKEFMSSLQISKVSLKHNGNYTCIAS---NDAATVSSERQLIVTV 758

  Fly   499 APIMELPPQNVTALDGKDATISCRAVGSPNPNITW-----IYNETQL--VDISSRVQILESGDLL 556
            .|...:.|.|...:.||...::|...|.|.|.:.|     |.|..|.  |.::.|:|||.:|.||
Zfish   759 PPRFRVQPNNQDGIYGKSEVLNCSVEGYPPPKVVWKHAKGIGNPQQYHPVPLTGRIQILSNGSLL 823

  Fly   557 ISNIRSVDAGLYICVRANEAGS-VKGEAYLSVLVRTQIIQPPVDTTVLLGLTATLQCKVSSDPSV 620
            |.::...|.|.|:|..:|..|| :.....|:|.:...|...|..|..:.|....|.|....:  .
Zfish   824 IRHVLEEDRGYYLCQASNGVGSDISKSMMLTVKIPAMITSHPNTTMAIKGQNKELNCTARGE--Y 886

  Fly   621 PYNIDWYREGQSSTPISNSQRIGV---------QADGQLEIQAVRASDVGSYACVVTSPGGNETR 676
            |..|.|.| |.:......:.|..:         :....|:::.....|...::|...:..|....
Zfish   887 PIIIRWER-GDTVIDPDRNPRYSITTSPNEKSDEVISTLKLKPAERGDSVFFSCHAINSYGEGRG 950

  Fly   677 AARLSVIELPFPPSNVKVERLPEPQQRSINVSWTPGFDGNSPISKFIIQRREVSELGPVPDPLLN 741
            ..:|:|.|.|.||   ::| :.|.:.||:|:.||..|||||.|:.:.|:.:..|      ||
Zfish   951 LIQLTVQEPPDPP---ELE-VREVKDRSMNLRWTQRFDGNSIITSYDIEYKNKS------DP--- 1002

  Fly   742 WITELSN----VSADQRWILLENLKAATVYQFRVSAVNRVGEGSPSEPSNVVELPQEAPSGPPVG 802
            |  ||.:    :|.......:..|..|:||..|:.:.|::|....|: ...:...:..|.|||:.
Zfish  1003 W--ELKHATRKISPTNNQANIVELHPASVYSIRMYSYNKIGRSQASK-ELTISTEEAPPDGPPME 1064

  Fly   803 FVGSARSMSEIITQWQPPLEEHRNGQILGYILRYRLFGYNNVPWS---YQNITNEAQRN---FLI 861
            .:....:...|...|:.|.:|.:||.|.||.:.||    .|.|.|   |..:..:|..:   :.:
Zfish  1065 VILQPMTSQSIRVTWKAPKKELQNGVIRGYQIGYR----ENGPGSNGQYSIVEMKATGDSEVYTL 1125

  Fly   862 QELITWKDYIVQIAAYNNMGVGVYTEGSKIKTKEGVPEAPPTNVKVEAINSTAARCRWTPPNPQQ 926
            ..|..:..|.|.:.|:|..|.|..:......|.|.||..||.||:...:.|..|...|:.|....
Zfish  1126 DNLKKFAQYGVVVQAFNRAGTGPSSSEINATTLEDVPSQPPQNVRAITVTSDEAVITWSEPPRMT 1190

  Fly   927 INGINQGYKIQAW------------QRRLIDGEWRDIERRMKTVPPSLIDPLAEQTAILGGLEKF 979
            :||:.:||::..|            |...::.:|.:::.         |....||.. |.|||||
Zfish  1191 LNGVLKGYRVVFWSLYPDGGGCCGGQTLGLNQKWGEMQN---------ITTTREQVE-LKGLEKF 1245

  Fly   980 TEYNISVLCFTDPGDGVASSQVAVMTMDDVPDEVTGLHFDDVSDRSVKVLWAPPRASNGILTGYT 1044
            |.|::.||.:|..||||.|:.:.:.|.:|.|....|:.....|..||.|.|.||...|||:..||
Zfish  1246 TNYSVQVLAYTQAGDGVRSNVLYIQTREDHPGPPAGIKAVPSSASSVVVSWLPPVKPNGIIRKYT 1310

  Fly  1045 V-------------RYQVKDRPDTLKSFNLTADDTELTVNQLQATTHYWFEIVAWTRVGSG-IPK 1095
            :             .|:.  .|:.| .:.:    |.||..|     .|.....|.|..|.| |.:
Zfish  1311 IYCSSPGSGQPAPSEYEA--NPELL-IYRI----THLTRGQ-----QYLIWAAAVTTAGRGNISE 1363

  Fly  1096 TATIQSGVEPVLPHAPTALALSNIEAFSVVLQFTPGFDGNSSITKWKVE--------GQTARNMT 1152
            ..|::          |...|.:.|.:|           |.:..|.|..|        |:....:.
Zfish  1364 KVTVE----------PAGKAPAKILSF-----------GGTVTTPWMKEVRLPCSSVGEPTPTIK 1407

  Fly  1153 WFTICEINDPDAETLTVTGLVPFTQYRLRLSASN---VVGSSKPSEA---------TKDFQTI-- 1203
            |       ..|:|...    :|.||...|...||   |:.|.|..::         |..|.||
Zfish  1408 W-------TKDSEDTA----IPVTQDGHRNILSNGTLVLRSVKAEDSGYYTCTATNTLGFDTIIV 1461

  Fly  1204 ----QARPKHPPFNVTVRAMSAQQLRVRWIPLQQTEWYGNP-----RGYNISYKQLVKTPGTIKY 1259
                |..|..|  .:||...|...:.:.|||       |:.     ||:.:.|    ....|.::
Zfish  1462 NLLVQVPPDQP--RLTVSTTSTSSITLAWIP-------GDNGGSSIRGFVLQY----SVDNTEEW 1513

  Fly  1260 VPRSVVIEDHTANSHVLDSLEEWTLYEVKMNACNDVGCSKESDTAVERTREAVPSYG---PLDVQ 1321
              :.|.|.. :..|..||:|...|.|:||:.|.|.||..:.|:....:|....|.:.   ||...
Zfish  1514 --KDVFISS-SERSFKLDNLRCGTWYKVKLAAKNSVGAGRISEIIEAKTHGREPQFNKDQPLFTH 1575

  Fly  1322 ANATSSTTVVVQWGEVPRQHRNGQIDGYKVFYAAADRGQQVLHKTIPNNATFTTTLTELKKYVVY 1386
            .|:|.:...:..|       .:|......|......:|... .:::..||:....|.||::...|
Zfish  1576 INSTHARMNLQGW-------TSGGCPITAVLLEFRPKGTWA-WQSVRTNASADIFLAELREATWY 1632

  Fly  1387 HVQVLAYTRLGNGALST------------PPIRVQTFE-DTPGVPSNVSFPDVSLTMARIIWDVP 1438
            .:::.|....|.|..|:            |||:....| |......::..|.:.:|:
Zfish  1633 ELKMKACNSAGCGNQSSQFATLDYDGSTIPPIKSARGEGDDVKKLFSIGCPVILVTL-------- 1689

  Fly  1439 VDPNGKILAYQVTYTLNGSAMLNYSREFPPSDRTFRATELLPGKYYSFSCTAQTRLGWGKIATAL 1503
                             |.|:|...|:.....|..|..:.                  ..:|..|
Zfish  1690 -----------------GMALLFIIRKKRKEKRLKRLRDA------------------KSLAEML 1719

  Fly  1504 VYTTNNRE-------RPQAP----SVPQI---------------SRSQIQAHQITFSWTPGRDGF 1542
            :.:.|||.       .||.|    .:|::               .::.|......||.:.....|
Zfish  1720 ISSKNNRSFDTPVKGPPQGPRLHIDIPRVQLLIEDKEGIKQIGEDKATIPVTDTEFSQSVNPQSF 1784

  Fly  1543 AP-LRYYTVEMRENEGRWQPLPERVDPSLSSFTAVGLRPYMTYQFRIQATNDLGPSAFSRESVIV 1606
            .. :..:...:.:|.|   ||.:..|          :||              |.:..||:||
Zfish  1785 CTGVSVHHPALIQNTG---PLIDMSD----------IRP--------------GTNPVSRKSV-- 1820

  Fly  1607 RTLPAAPAVGVGGLKVVPITTTSVRVQWSALETALWNGDASTGGYRILYQQLSDFPTALQSTPKT 1671
                          |....|......||:     |....|||....:    .||:.|.      .
Zfish  1821 --------------KSAHSTRNRYSSQWT-----LTKCQASTPARTL----TSDWRTV------G 1856

  Fly  1672 DVHGI--NENSVVLSDLQQD 1689
            ..|||  .|:....:.|.||
Zfish  1857 SQHGITVTESDSYSASLSQD 1876

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdk	NP_001284756.1	Ig	71..157	CDD:299845	28/77 (36%)
		I-set	72..150	CDD:254352	28/70 (40%)
		Ig	172..245	CDD:299845	17/90 (19%)
		IG_like	280..356	CDD:214653	21/95 (22%)
		Ig	280..343	CDD:299845	18/82 (22%)
		IG_like	375..450	CDD:214653	16/77 (21%)
		Ig	378..447	CDD:143165	15/71 (21%)
		Ig	506..587	CDD:299845	29/88 (33%)
		IG_like	506..587	CDD:214653	29/88 (33%)
		I-set	592..682	CDD:254352	17/98 (17%)
		Ig	595..682	CDD:299845	16/95 (17%)
		FN3	686..789	CDD:238020	32/106 (30%)
		FN3	798..893	CDD:238020	26/100 (26%)
		FN3	901..1005	CDD:238020	34/115 (30%)
		fn3	1011..1094	CDD:278470	25/96 (26%)
		FN3	1108..1202	CDD:238020	23/113 (20%)
		FN3	1210..1308	CDD:238020	27/102 (26%)
		fn3	1317..1402	CDD:278470	17/84 (20%)
		FN3	1415..1507	CDD:238020	10/91 (11%)
		FN3	1513..1608	CDD:238020	20/114 (18%)
		fn3	1617..1708	CDD:278470	18/75 (24%)
		FN3	1722..1823	CDD:238020
		FN3	1828..1920	CDD:238020
		FN3	1927..2016	CDD:238020
dscaml1	XP_005157551.1	IG_like	112..184	CDD:214653
		Ig	112..183	CDD:143165
		Ig	194..287	CDD:299845
		I-set	302..380	CDD:254352	30/92 (33%)
		IGc2	309..370	CDD:197706	25/62 (40%)
		IGc2	399..458	CDD:197706	11/60 (18%)
		I-set	477..571	CDD:254352	22/105 (21%)
		Ig	477..567	CDD:299845	22/101 (22%)
		IG_like	581..662	CDD:214653	16/100 (16%)
		IGc2	588..646	CDD:197706	14/61 (23%)
		Ig	684..751	CDD:143165	5/69 (7%)
		IG_like	686..756	CDD:214653	5/72 (7%)
		I-set	760..855	CDD:254352	30/94 (32%)
		Ig7_DSCAM	778..855	CDD:143211	25/76 (33%)
		IG_like	865..956	CDD:214653	16/93 (17%)
		Ig	873..963	CDD:299845	17/92 (18%)
		FN3	959..1053	CDD:238020	32/109 (29%)
		FN3	1060..1157	CDD:238020	26/100 (26%)
		FN3	1165..1271	CDD:238020	34/115 (30%)
		FN3	1276..1367	CDD:238020	27/102 (26%)
		IGc2	1392..1455	CDD:197706	14/73 (19%)
		FN3	1486..1559	CDD:238020	23/86 (27%)
		FN3	1573..1649	CDD:238020	15/83 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910