Protein Alignment Hmt4-20 and KMT5C

DIOPT Version :10

• Sequence 1: NP_569853.1
• Gene: Hmt4-20 / 31015
• FlyBaseID: FBgn0025639
• Length: 1300
• Species: Drosophila melanogaster
• Sequence 2: NP_116090.2
• Gene: KMT5C / 84787
• HGNCID: 28405
• Length: 462
• Species: Homo sapiens
• Alignment Length: 278
• Identity: 139/278 - (50%)
• Similarity: 183/278 - (65%)
• Gaps: 13/278 - (4%)

  Fly   152 MSPRELSENDDLATSLILDPHLGFQTHKMNIRFRPLKVDTQQLKAIVDDFIHTQNYDIAIQRIYE 216
            ::.|||.|||||||||:|||:|||:|||||:...|.....|.|::.::.|:..::.:.|.:.:..
Human     6 VTARELCENDDLATSLVLDPYLGFRTHKMNVSPVPPLRRQQHLRSALETFLRQRDLEAAYRALTL 70

  Fly   217 GPWIPRHLKNKNKIATKRLHDHIVRYLRVFDKDSGFAIEACYRYTLEEQRGAKISSTKRWSKNDK 281
            |.|..|:.:::.......|..|:.||||.|..:|||.|..|.||:: |..||||.||:.|.||:|
Human    71 GGWTARYFQSRGPRQEAALKTHVYRYLRAFLPESGFTILPCTRYSM-ETNGAKIVSTRAWKKNEK 134

  Fly   282 IECLVGCIAELTEAEEAALLHSGKNDFSVMYSCRKNCAQLWLGPAAYINHDCRANCKFLATGRDT 346
            :|.||||||||.||:| .||.:|:||||:|||.||..|||||||||:|||||:.||||:....:.
Human   135 LELLVGCIAELREADE-GLLRAGENDFSIMYSTRKRSAQLWLGPAAFINHDCKPNCKFVPADGNA 198

  Fly   347 ACVKVLRDIEVGEEITCFYGEDFFGDSNRYCECETCERRGTGAFAGKDDGLMLGLSMGLGLASSG 411
            ||||||||||.|:|:||||||.|||:.|.:|||.||||:|.|||..:.....|           .
Human   199 ACVKVLRDIEPGDEVTCFYGEGFFGEKNEHCECHTCERKGEGAFRTRPREPAL-----------P 252

  Fly   412 PGNNGGYRLRETDNRINR 429
            |.....|:||||..|:.:
Human   253 PRPLDKYQLRETKRRLQQ 270

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hmt4-20	NP_569853.1	SET	249..390	CDD:394802	91/140 (65%)
KMT5C	NP_116090.2	SET_KMT5C	102..243	CDD:380962	92/142 (65%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	325..348
		Required for heterochromatin localization. /evidence=ECO:0000250	346..435