back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hmt4-20 and Kmt5b

DIOPT Version :9

Sequence 1:	NP_001245453.1	Gene:	Hmt4-20 / 31015	FlyBaseID:	FBgn0025639	Length:	1300	Species:	Drosophila melanogaster
Sequence 2:	NP_001101982.1	Gene:	Kmt5b / 361688	RGDID:	1311637	Length:	883	Species:	Rattus norvegicus

Alignment Length:	1078	Identity:	313/1078 - (29%)
Similarity:	448/1078 - (41%)	Gaps:	326/1078 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 SHHHQSHQSSNGSGGGSAGSGSGSGSVVSGLNGCNGSA----VSRLSQSTGMSPRELSENDDLAT 165
            |:.||.:||.....|..| ..:|..:|....|.|:|::    .||...|:|||.:||.|||||||
  Rat    22 SNDHQQNQSKLQHAGKDA-LKTGRNAVERRPNRCHGNSGFEGQSRYVPSSGMSAKELCENDDLAT 85

  Fly   166 SLILDPHLGFQTHKMN-----------------------IRFRPLKVDTQQLKAIVDDFIHTQNY 207
            ||:|||:|||||||||                       :||||:|...::||.:::.|...::.
  Rat    86 SLVLDPYLGFQTHKMNTSAFPSRSSRHISKADSFSHNNPMRFRPIKGRQEELKEVIERFKKDEHL 150

  Fly   208 DIAIQRIYEGPWIPRHLKNKNKIATKRLHDHIVRYLRVFDKDSGFAIEACYRYTLEEQRGAKISS 272
            :.|.:.:..|.|...:..||||:..|...:|:..|||:|..||||.|..|.||: .||.||||.:
  Rat   151 EKAFKCLTSGEWARHYFLNKNKMQEKLFKEHVFIYLRMFATDSGFEILPCNRYS-SEQNGAKIVA 214

  Fly   273 TKRWSKNDKIECLVGCIAELTEAEEAALLHSGKNDFSVMYSCRKNCAQLWLGPAAYINHDCRANC 337
            ||.|.:|||||.||||||||:|.||..||..|:||||||||.|||||||||||||:||||||.||
  Rat   215 TKEWKRNDKIELLVGCIAELSEIEENMLLRHGENDFSVMYSTRKNCAQLWLGPAAFINHDCRPNC 279

  Fly   338 KFLATGRDTACVKVLRDIEVGEEITCFYGEDFFGDSNRYCECETCERRGTGAFAGKDDGLMLGLS 402
            ||::|||||||||.|||||.||||:|:||:.|||::|.:|||.||||||||||..:
  Rat   280 KFVSTGRDTACVKALRDIEPGEEISCYYGDGFFGENNEFCECYTCERRGTGAFKSR--------- 335

  Fly   403 MGLGLASSGPGNNGGYRLRETDNRINRIKSRANSTNSTSNS--NSNTN-DSTGPSETSSTN---- 460
              :||.:..|..|..|.|||||.|:||:|...:|:.|:.:.  :|||: |:|...:.:::|
  Rat   336 --VGLPAPAPVINSKYGLRETDKRLNRLKKLGDSSKSSDSQSVSSNTDADTTQEKDNATSNRKSS 398

  Fly   461 -GLVASGGAGGATGAAMLPTP-SQQSTGGKEATAAVSLLEKKL---PNVVVSPLTM----KELRQ 516
             |:..:..:...|..:|...| :..||..|......|.:.|||   ...::|.:.:    |.|.|
  Rat   399 VGVKKNSKSRALTRQSMPRVPAASNSTSPKLVHMNNSRVPKKLRKPAKPLLSKIKLRNHCKRLDQ 463

  Fly   517 KGMTKYDAEM-----------IMANAAYQQQHHHQHHFH----------HHHHHHHHHHNHGQHA 560
            |. |....||           :..|...:::...:...|          |....|..:...|.|:
  Rat   464 KS-TSRKLEMGNLVLKEPKVVLYKNLPIKKEREAEGPVHAAVGSGCLTRHAAREHRQNPGRGAHS 527

  Fly   561 STGAEATAAVQQMAAMQKPGVGGTGAAGNAGATTVSSVAAGAGSEVNGGRSTSLRKSMRVNSTSS 625
            ...:.......:.:...:.|:..|        |.:..    |.|.::|.::..|..    ...|.
  Rat   528 QGDSLPCTYTTRRSLRTRTGLKET--------TDIKL----APSPLDGYKNGILEP----YPDSG 576

  Fly   626 SISTASADEVIAPVVA----------ASISLPSKAPVVLMPRCKPAQMAIAALHQSQQRQLRRSE 680
            ...|....|.:||..|          .|.|.||:..   ..:.||    :..|.:::......|.
  Rat   577 QQPTPEVLEELAPETALREEASQECPKSDSCPSRKK---FRQGKP----VKHLAKTEDCSPEHSF 634

  Fly   681 RQKEKLTD--------GESSDTSSEQQKKEQKQQDHQLPQKMFSLAEEP------QPEKSEEK-- 729
            ..|:.|.|        ||.|.|.             ::|......|..|      .|:....|
  Rat   635 PGKDGLPDLPGPHPDQGEPSGTV-------------RVPVSYTDSAPSPVGCSIVTPDSFTTKDS 686

  Fly   730 ----QQEQQKRVTRNSAGRVGLVARLATAHNNNI--ATTTNSSSSSNKATTITNCNNHNSNNSSR 788
                |.::::||||..       |:|...:::.|  .|......||:|.      |:|.|::
  Rat   687 FRTAQSKKKRRVTRYD-------AQLILENSSGIPKLTLRRRHDSSSKT------NDHESDS--- 735

  Fly   789 INHNSNLSSRLSVKSRKPAPSEASSIPSSTSSENQQQQATRRSCSPTPAYKKNLLASFDPDPPST 853
            :|     ||::|:|..|...|:::...:..|:.                      .|..|...||
  Rat   736 VN-----SSKISIKLSKDHESDSNLYVAKLSNG----------------------VSSGPGSSST 773

  Fly   854 QGIKEQLKDESVTYSPVKQKRSRRAAALAAAQSIHCEALGGFPTGSTGSQRKRAQAGEPTTSCSS 918
            : :|.|||.:..:..|             .|:.:|                      |....||
  Rat   774 K-LKIQLKRDEESRGP-------------CAEGLH----------------------ENGVCCS- 801

  Fly   919 TTISNVEPLLKTPERRLKLTLRMKRSPILDEVIELGTSLSNGGAGRGAPGSHREGTAGEGSVRSA 983
                  :||                 .:|:..:|:...           ..:.|.:..:
  Rat   802 ------DPL-----------------SLLESQMEVDDY-----------SQYEEDSTDD------ 826

  Fly   984 LNLTGSSSNGIEYEILRMEGISEHGNDDDEDEEEDDEEPAAEEEEEPPPKEELQLVNKKQRKKQR 1048
                .|||.|.|.|            :|.||:.:||..|
  Rat   827 ----SSSSEGEEEE------------EDCEDDFDDDFIP-------------------------- 849

  Fly  1049 SRSRSSQRRSPAPSSVYGTPQKKRLRLIFGNESHTIDI 1086
                              .|..||||||.|.:|..|||
  Rat   850 ------------------LPPAKRLRLIVGKDSIDIDI 869

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.