Protein Alignment Hmt4-20 and Kmt5c

DIOPT Version :10

• Sequence 1: NP_569853.1
• Gene: Hmt4-20 / 31015
• FlyBaseID: FBgn0025639
• Length: 1300
• Species: Drosophila melanogaster
• Sequence 2: NP_001100945.1
• Gene: Kmt5c / 308345
• RGDID: 1305226
• Length: 470
• Species: Rattus norvegicus
• Alignment Length: 280
• Identity: 139/280 - (49%)
• Similarity: 183/280 - (65%)
• Gaps: 17/280 - (6%)

  Fly   152 MSPRELSENDDLATSLILDPHLGFQTHKMNIRFRPLKVDTQQLKAIVDDFIHTQNYDIAIQRIYE 216
            ::.|||.|||||||||:|||:|||:|||||:...|.......|::.::.|:..::.:.|.:.:..
  Rat     6 VTARELCENDDLATSLVLDPYLGFRTHKMNVSPVPTLRRQHHLRSALEAFLRQRDLEAAFRALTL 70

  Fly   217 GPWIPRHLKNKNKIATKRLHDHIVRYLRVFDKDSGFAIEACYRYTLEEQRGAKISSTKRWSKNDK 281
            |.|:..:.:|:.......|.:||..|||.|..:|||.|..|.||:: |..||||.||:.|.||:|
  Rat    71 GGWMAHYFQNRAPRQEAALKNHIFCYLRAFLPESGFTILPCTRYSM-ETNGAKIVSTRAWKKNEK 134

  Fly   282 IECLVGCIAELTEAEEAALLHSGKNDFSVMYSCRKNCAQLWLGPAAYINHDCRANCKFLATGRDT 346
            :|.||||||||.| |:..||.:|:||||||||.||..|||||||||:|||||:.||||:.:..:|
  Rat   135 LELLVGCIAELRE-EDEYLLRAGENDFSVMYSTRKRSAQLWLGPAAFINHDCKPNCKFVPSDGNT 198

  Fly   347 ACVKVLRDIEVGEEITCFYGEDFFGDSNRYCECETCERRGTGAF--AGKDDGLMLGLSMGLGLAS 409
            ||||||||||.|:|:||||||.|||:.|.:|||.||||:|.|||  ..::..|.
  Rat   199 ACVKVLRDIEPGDEVTCFYGEGFFGEKNEHCECYTCERKGEGAFRLQPREPELR----------- 252

  Fly   410 SGPGNNGGYRLRETDNRINR 429
              |.....|.||||..|:.:
  Rat   253 --PRPLDKYELRETKRRLQQ 270

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hmt4-20	NP_569853.1	SET	249..390	CDD:394802	92/140 (66%)
Kmt5c	NP_001100945.1	SET_KMT5C	102..243	CDD:380962	93/142 (65%)
		PHA02682	245..>310	CDD:177464	8/39 (21%)
		Required for heterochromatin localization. /evidence=ECO:0000250	350..443