Protein Alignment Hmt4-20 and Kmt5b

DIOPT Version :10

• Sequence 1: NP_569853.1
• Gene: Hmt4-20 / 31015
• FlyBaseID: FBgn0025639
• Length: 1300
• Species: Drosophila melanogaster
• Sequence 2: NP_001161357.1
• Gene: Kmt5b / 225888
• MGIID: 2444557
• Length: 883
• Species: Mus musculus
• Alignment Length: 1079
• Identity: 306/1079 - (28%)
• Similarity: 439/1079 - (40%)
• Gaps: 328/1079 - (30%)

  Fly   105 SHHHQSHQSSNGSGGGSAGSGSGSGSVVSGLNGCNGSA----VSRLSQSTGMSPRELSENDDLAT 165
            |:.||.:||......|.....:|..:|....:.|:|::    .||...|:|||.:||.|||||||
Mouse    22 SNDHQQNQSKLQQHSGKDTLKTGRNAVERRSSRCHGNSGFEGQSRYVPSSGMSAKELCENDDLAT 86

  Fly   166 SLILDPHLGFQTHKMN-----------------------IRFRPLKVDTQQLKAIVDDFIHTQNY 207
            ||:|||:|||||||||                       :||||:|...::||.:::.|...::.
Mouse    87 SLVLDPYLGFQTHKMNTSAFPSRSSRHISKADSFSHNNPVRFRPIKGRQEELKEVIERFKKDEHL 151

  Fly   208 DIAIQRIYEGPWIPRHLKNKNKIATKRLHDHIVRYLRVFDKDSGFAIEACYRYTLEEQRGAKISS 272
            :.|.:.:..|.|...:..||||:..|...:|:..|||:|..||||.|..|.||: .||.||||.:
Mouse   152 EKAFKCLTSGEWARHYFLNKNKMQEKLFKEHVFIYLRMFATDSGFEILPCNRYS-SEQNGAKIVA 215

  Fly   273 TKRWSKNDKIECLVGCIAELTEAEEAALLHSGKNDFSVMYSCRKNCAQLWLGPAAYINHDCRANC 337
            ||.|.:|||||.||||||||:|.||..||..|:||||||||.|||||||||||||:||||||.||
Mouse   216 TKEWKRNDKIELLVGCIAELSEIEENMLLRHGENDFSVMYSTRKNCAQLWLGPAAFINHDCRPNC 280

  Fly   338 KFLATGRDTACVKVLRDIEVGEEITCFYGEDFFGDSNRYCECETCERRGTGAFAGKDDGLMLGLS 402
            ||::|||||||||.|||||.||||:|:||:.|||::|.:|||.||||||||||..:
Mouse   281 KFVSTGRDTACVKALRDIEPGEEISCYYGDGFFGENNEFCECYTCERRGTGAFKSR--------- 336

  Fly   403 MGLGLASSGPGNNGGYRLRETDNRINRIKSRANST-NSTSNS-NSNTNDSTGPSETSSTNGLVAS 465
              :||.:..|..|..|.|||||.|:||:|...:|: ||.|.| :|||:..|...:.::|:...:|
Mouse   337 --VGLPAPAPVINSKYGLRETDKRLNRLKKLGDSSKNSDSQSVSSNTDADTTQEKDNATSNRKSS 399

  Fly   466 GGAGGATGAAMLPTPSQQSTGGKEATAAVSLLEKKLPNV----------VVSPLTM----KELRQ 516
            .|...::.:..|..||.........:.:..|:....|.|          ::|.:.:    |.|.|
Mouse   400 VGVKKSSKSRALTRPSMPRVPAASNSTSPKLVHTNNPRVPKKLRKPAKPLLSKIRLRNHCKRLDQ 464

  Fly   517 KG----------MTKYDAEMIMANAAYQQQHHHQHHFH--------HHHHHHHHHHNHGQHASTG 563
            |.          :.|....::..|...:::...:...|        ..|....|..|||:.|.:.
Mouse   465 KSASRKLEMGSLVLKEPKVVLYKNLPIKKEREPEGPAHAAVGSGCLTRHAAREHRQNHGRGAHSQ 529

  Fly   564 AEATAAVQQMAAMQKPGVGGTGAAGNAGATTVSSVAAGAG-----------SEVNGGRSTSLRKS 617
            .::.....                     ||..|:....|           |.::|.::..|...
Mouse   530 GDSLPCTY---------------------TTRRSLRTRTGLKETTDIKLEPSPLDGYKNGILEPC 573

  Fly   618 MRVNSTSSSISTASADEVIAPVVA----ASISLPSKAPVVLMPRCKPAQMAIAALHQSQQRQLRR 678
                ..|....|....|.:||..|    ||...|.....:...:.:..: .:..|.:::......
Mouse   574 ----PDSGQQPTPEVLEELAPETAHREEASQECPKNDSCLSRKKFRQVK-PVKHLAKTEDCSPEH 633

  Fly   679 SERQKEKLTD--------GESSDTSSEQQKKEQKQQDHQLPQKMFSLAEEP-----------QPE 724
            |...|:.|.|        ||.|.|.             ::|......|..|           ..:
Mouse   634 SFPGKDGLPDLPGSHPDQGEPSGTV-------------RVPVSHTDSAPSPVGCSVVAPDSFTKD 685

  Fly   725 KSEEKQQEQQKRVTRNSAGRVGLVARLATAHNNNI--ATTTNSSSSSNKATTITNCNNHNSNNSS 787
            .....|.::::||||..       |:|...:::.|  .|......||:|.      |:|.|:.
Mouse   686 SFRTAQSKKKRRVTRYD-------AQLILENSSGIPKLTLRRRHDSSSKT------NDHESDG-- 735

  Fly   788 RINHNSNLSSRLSVKSRKPAPSEASSIPSSTSSENQQQQATRRSCSPTPAYKKNLLASFDPDPPS 852
             :|     ||::|:|..|...|:::...:..|:.                      .|..|...|
Mouse   736 -VN-----SSKISIKLSKDHDSDSNLYVAKLSNG----------------------VSAGPGSSS 772

  Fly   853 TQGIKEQLKDESVTYSPVKQKRSRRAAALAAAQSIHCEALGGFPTGSTGSQRKRAQAGEPTTSCS 917
            |: :|.|||.:..:..|             .|:.:|                      |....||
Mouse   773 TK-LKIQLKRDEESRGP-------------CAEGLH----------------------ENGVCCS 801

  Fly   918 STTISNVEPLLKTPERRLKLTLRMKRSPILDEVIELGTSLSNGGAGRGAPGSHREGTAGEGSVRS 982
                   :||                 .:|:..:|:...           ..:.|.:..|
Mouse   802 -------DPL-----------------SLLESQMEVDDY-----------SQYEEDSTDE----- 826

  Fly   983 ALNLTGSSSNGIEYEILRMEGISEHGNDDDEDEEEDDEEPAAEEEEEPPPKEELQLVNKKQRKKQ 1047
                 .|||.|.|.|            :|.||:.:||..|
Mouse   827 -----SSSSEGEEEE------------EDCEDDFDDDFIP------------------------- 849

  Fly  1048 RSRSRSSQRRSPAPSSVYGTPQKKRLRLIFGNESHTIDI 1086
                               .|..||||||.|.:|..|||
Mouse   850 -------------------LPPAKRLRLIVGKDSIDIDI 869

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hmt4-20	NP_569853.1	SET	249..390	CDD:394802	103/140 (74%)
Kmt5b	NP_001161357.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..67		11/44 (25%)
		SET_KMT5B	193..336	CDD:380961	105/143 (73%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	364..442		18/77 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	613..750		33/171 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	810..848		14/70 (20%)