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Protein Alignment Hmt4-20 and Kmt5b

DIOPT Version :9

Sequence 1:	NP_001245453.1	Gene:	Hmt4-20 / 31015	FlyBaseID:	FBgn0025639	Length:	1300	Species:	Drosophila melanogaster
Sequence 2:	NP_001161357.1	Gene:	Kmt5b / 225888	MGIID:	2444557	Length:	883	Species:	Mus musculus

Alignment Length:	1079	Identity:	306/1079 - (28%)
Similarity:	439/1079 - (40%)	Gaps:	328/1079 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 SHHHQSHQSSNGSGGGSAGSGSGSGSVVSGLNGCNGSA----VSRLSQSTGMSPRELSENDDLAT 165
            |:.||.:||......|.....:|..:|....:.|:|::    .||...|:|||.:||.|||||||
Mouse    22 SNDHQQNQSKLQQHSGKDTLKTGRNAVERRSSRCHGNSGFEGQSRYVPSSGMSAKELCENDDLAT 86

  Fly   166 SLILDPHLGFQTHKMN-----------------------IRFRPLKVDTQQLKAIVDDFIHTQNY 207
            ||:|||:|||||||||                       :||||:|...::||.:::.|...::.
Mouse    87 SLVLDPYLGFQTHKMNTSAFPSRSSRHISKADSFSHNNPVRFRPIKGRQEELKEVIERFKKDEHL 151

  Fly   208 DIAIQRIYEGPWIPRHLKNKNKIATKRLHDHIVRYLRVFDKDSGFAIEACYRYTLEEQRGAKISS 272
            :.|.:.:..|.|...:..||||:..|...:|:..|||:|..||||.|..|.||: .||.||||.:
Mouse   152 EKAFKCLTSGEWARHYFLNKNKMQEKLFKEHVFIYLRMFATDSGFEILPCNRYS-SEQNGAKIVA 215

  Fly   273 TKRWSKNDKIECLVGCIAELTEAEEAALLHSGKNDFSVMYSCRKNCAQLWLGPAAYINHDCRANC 337
            ||.|.:|||||.||||||||:|.||..||..|:||||||||.|||||||||||||:||||||.||
Mouse   216 TKEWKRNDKIELLVGCIAELSEIEENMLLRHGENDFSVMYSTRKNCAQLWLGPAAFINHDCRPNC 280

  Fly   338 KFLATGRDTACVKVLRDIEVGEEITCFYGEDFFGDSNRYCECETCERRGTGAFAGKDDGLMLGLS 402
            ||::|||||||||.|||||.||||:|:||:.|||::|.:|||.||||||||||..:
Mouse   281 KFVSTGRDTACVKALRDIEPGEEISCYYGDGFFGENNEFCECYTCERRGTGAFKSR--------- 336

  Fly   403 MGLGLASSGPGNNGGYRLRETDNRINRIKSRANST-NSTSNS-NSNTNDSTGPSETSSTNGLVAS 465
              :||.:..|..|..|.|||||.|:||:|...:|: ||.|.| :|||:..|...:.::|:...:|
Mouse   337 --VGLPAPAPVINSKYGLRETDKRLNRLKKLGDSSKNSDSQSVSSNTDADTTQEKDNATSNRKSS 399

  Fly   466 GGAGGATGAAMLPTPSQQSTGGKEATAAVSLLEKKLPNV----------VVSPLTM----KELRQ 516
            .|...::.:..|..||.........:.:..|:....|.|          ::|.:.:    |.|.|
Mouse   400 VGVKKSSKSRALTRPSMPRVPAASNSTSPKLVHTNNPRVPKKLRKPAKPLLSKIRLRNHCKRLDQ 464

  Fly   517 KG----------MTKYDAEMIMANAAYQQQHHHQHHFH--------HHHHHHHHHHNHGQHASTG 563
            |.          :.|....::..|...:::...:...|        ..|....|..|||:.|.:.
Mouse   465 KSASRKLEMGSLVLKEPKVVLYKNLPIKKEREPEGPAHAAVGSGCLTRHAAREHRQNHGRGAHSQ 529

  Fly   564 AEATAAVQQMAAMQKPGVGGTGAAGNAGATTVSSVAAGAG-----------SEVNGGRSTSLRKS 617
            .::.....                     ||..|:....|           |.::|.::..|...
Mouse   530 GDSLPCTY---------------------TTRRSLRTRTGLKETTDIKLEPSPLDGYKNGILEPC 573

  Fly   618 MRVNSTSSSISTASADEVIAPVVA----ASISLPSKAPVVLMPRCKPAQMAIAALHQSQQRQLRR 678
                ..|....|....|.:||..|    ||...|.....:...:.:..: .:..|.:::......
Mouse   574 ----PDSGQQPTPEVLEELAPETAHREEASQECPKNDSCLSRKKFRQVK-PVKHLAKTEDCSPEH 633

  Fly   679 SERQKEKLTD--------GESSDTSSEQQKKEQKQQDHQLPQKMFSLAEEP-----------QPE 724
            |...|:.|.|        ||.|.|.             ::|......|..|           ..:
Mouse   634 SFPGKDGLPDLPGSHPDQGEPSGTV-------------RVPVSHTDSAPSPVGCSVVAPDSFTKD 685

  Fly   725 KSEEKQQEQQKRVTRNSAGRVGLVARLATAHNNNI--ATTTNSSSSSNKATTITNCNNHNSNNSS 787
            .....|.::::||||..       |:|...:::.|  .|......||:|.      |:|.|:.
Mouse   686 SFRTAQSKKKRRVTRYD-------AQLILENSSGIPKLTLRRRHDSSSKT------NDHESDG-- 735

  Fly   788 RINHNSNLSSRLSVKSRKPAPSEASSIPSSTSSENQQQQATRRSCSPTPAYKKNLLASFDPDPPS 852
             :|     ||::|:|..|...|:::...:..|:.                      .|..|...|
Mouse   736 -VN-----SSKISIKLSKDHDSDSNLYVAKLSNG----------------------VSAGPGSSS 772

  Fly   853 TQGIKEQLKDESVTYSPVKQKRSRRAAALAAAQSIHCEALGGFPTGSTGSQRKRAQAGEPTTSCS 917
            |: :|.|||.:..:..|             .|:.:|                      |....||
Mouse   773 TK-LKIQLKRDEESRGP-------------CAEGLH----------------------ENGVCCS 801

  Fly   918 STTISNVEPLLKTPERRLKLTLRMKRSPILDEVIELGTSLSNGGAGRGAPGSHREGTAGEGSVRS 982
                   :||                 .:|:..:|:...           ..:.|.:..|
Mouse   802 -------DPL-----------------SLLESQMEVDDY-----------SQYEEDSTDE----- 826

  Fly   983 ALNLTGSSSNGIEYEILRMEGISEHGNDDDEDEEEDDEEPAAEEEEEPPPKEELQLVNKKQRKKQ 1047
                 .|||.|.|.|            :|.||:.:||..|
Mouse   827 -----SSSSEGEEEE------------EDCEDDFDDDFIP------------------------- 849

  Fly  1048 RSRSRSSQRRSPAPSSVYGTPQKKRLRLIFGNESHTIDI 1086
                               .|..||||||.|.:|..|||
Mouse   850 -------------------LPPAKRLRLIVGKDSIDIDI 869

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.