DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment su(sable) and Zc3h6

DIOPT Version :9

Sequence 1:	NP_001284753.1	Gene:	su(sable) / 31012	FlyBaseID:	FBgn0003575	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_848491.2	Gene:	Zc3h6 / 78751	MGIID:	1926001	Length:	1177	Species:	Mus musculus

Alignment Length:	1372	Identity:	261/1372 - (19%)
Similarity:	418/1372 - (30%)	Gaps:	536/1372 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 DLEE-DLEDGEIDDD--EEDEQQSSKIQVQKKTFVGDDDVQFVGVEAKNQNDDEDVVYVGPSTDA 73
            |.|: :||||||||.  ||.:.|.:|                     :|:....:..|
Mouse    10 DREDGELEDGEIDDAGFEETQDQEAK---------------------ENEKQKNEKAY------- 46

  Fly    74 VCLQNSNSTKSKKPRPLEDDHASSIELAIANALKKKGIEPPMPRMRSSNQDTSDQSLEGSGEGLA 138
                ..:..|.||.|..:.......|       |.|...|       |..|:||.||:...|.:.
Mouse    47 ----RKSRKKHKKEREKKKSKRRKHE-------KHKHNSP-------SGDDSSDYSLDSDVERMQ 93

  Fly   139 TAN------------PLLQSTRSSRRRKRKKEREREQKKDKEQQNRS------------------ 173
            ::.            |..|..|.|......|:.:..:|.:.::...|
Mouse    94 SSRKKRTSSYRDYDVPFSQHRRISGSYMTSKKSQHNKKTNSKEYAESSFYSDDYFGNYSDDNFGN 158

  Fly   174 ---RRDENDVSVVPGGVEDMDEYEMMNVRGGS--------------PPPG------------GAA 209
               :..|.|.|      ..:..|.......||              .|||            |..
Mouse   159 YSNQEGEEDFS------SQLKYYRQSQESSGSSFSKESGKKLRSKGSPPGTEYRIKSFDVSHGHL 217

  Fly   210 PP-----LSSCGQR-------FSGADWDMDDGSAATGAAGLGAGGGGGYNSHSSYDSYSDEETNG 262
            .|     ...||.|       |||    |||                       :..||.
Mouse   218 LPKKIRRKEHCGARVIKGPYVFSG----MDD-----------------------FQEYSK----- 250

  Fly   263 PG----LMNQRRRTRRDNEKEHQRGVNNR-KRRDRDRLEGG-LAGSGSKRNRRDSGEGGGGGQEK 321
            ||    :|.|        |..:|..|.:: |:..:..|||. :.|...|.|.....|
Mouse   251 PGKKWKVMTQ--------EFINQHTVEHKGKQICKYFLEGRCIKGDHCKFNHDAELE-------- 299

  Fly   322 MGGSNRVEPRKLELCKFYLMDCCAKRDKCSYMHKEFPCKYYYLGMDCYAGDDCLFYHGEPLSEQL 386
                     :|.|:||:||...|.|.:.|.|||.|||||:|:.|..||.||.|.|.| :.|:::.
Mouse   300 ---------KKKEVCKYYLQGYCTKGENCIYMHSEFPCKFYHSGAKCYQGDKCKFSH-DDLTKET 354

  Fly   387 RNVLLKHMETAPKEILGDFKRISRDI---AIVQMTRRHEQLCDQLNRENTWNSIGCGLMGKRQDH 448
            |.:|.|.: .|.:|::.:.:|...::   .|..:.:...               |.||:....:|
Mouse   355 RKLLDKVL-NADEELVNEDERELEELRKRGITPLPKPPP---------------GVGLLPTPSEH 403

  Fly   449 QMQQQQQQLQHQQLQQQQEQQQTQQQAAADGGGCIPSLLDMVI---------------------N 492
            ......:......|....::              ||||.::|:                     :
Mouse   404 FPFSDPEDDFETDLSDDMKK--------------IPSLFEIVVKPTVDLAHKIGKKPPAFYNSTS 454

  Fly   493 PPLSENKRKSRWTEKM---------GAKAAAGAAGSSERDSTSPDAKPL-----PPHLD----LA 539
            ||..:.:..|...::|         |:|...|.. |..|...||...|.     ||..:    |.
Mouse   455 PPGPQFEESSHCPQRMYSSESSPGPGSKVPQGCE-SPVRHPGSPGHHPCVGPPGPPMQENPSLLP 518

  Fly   540 NLSHVLSAENMAKLNKLGITNLEQM----------------LQVP-FGQLTEAGLTLVEIGEIQR 587
            :.|.::...:.|.    |:..|:.:                ::|| ....:.|.|......|:||
Mouse   519 SSSEIVGPHSQAG----GLVQLDTLPSMGGAYHSPGFPGHSVKVPRESHSSPASLYQQMPSEMQR 579

  Fly   588 KA------------EDAKPQTQA----------------ELESSTPPSKRETEANNSNSKSNGLI 624
            .|            :|..||..|                |.....||..|:|....|...|:
Mouse   580 SADSESMQGSAEFYDDYYPQHAAHNFQPPDNSADEMWHEEFAQQQPPIARDTAHLGSGPNSS--- 641

  Fly   625 MVDYTQYLKDAHVSFSGNDP----------LDDDRDDDEQLIIDDGNDSTAEEDQQPKKAKAPPA 679
                ::......:|.||..|          ....::|:|.........|:.|||.         .
Mouse   642 ----SRMTSHCPLSASGLPPAVQRALFIPLTQRYQEDEEPAGTQPHRASSKEEDD---------T 693

  Fly   680 ATHESSTEEAPLPSVFDLPSFMNNMLGQG--SSARQLLPASATSPNQENAHLPGGDQSTHKSAPI 742
            |...||:||..               |.|  |..|.|...:.|..||:   ||    .|..|.|
Mouse   694 ANWYSSSEEEE---------------GSGVKSILRTLQKQTGTLRNQQ---LP----PTELSVP- 735

  Fly   743 GGGTSTNVLGRILFGDKQSDPEARAAFYRDI-------------IRNPFKAHSGDG--------- 785
               |...:.......::..||..|....:||             :.:|.|.....|
Mouse   736 ---TDPRLAKEKRKRNQVVDPRLRTVPRQDIKKPHESVPVDLRLVWDPKKLRGNGGAPGGSSARG 797

  Fly   786 -DVDSSNENSNSNSHSLTPTPTPEPGSQSPKPEDHDQDMP-ELPVIAPALP-PTTPSLYV---RR 844
             :.|..:.|:.:|             .:|.:.||.|:|.. ||...|..:| .::|.:.:   |.
Mouse   798 AEFDLRHTNAGAN-------------HKSKRREDDDEDSERELREKAFLIPLDSSPGIVLQDPRS 849

  Fly   845 SMYDFDPVKEQ---------EH---GRQELLTEEKEQYQRDTDMRLPFEPM-------------K 884
            .:..|..:|..         :|   ..::||.....:....:.:.||..|:             .
Mouse   850 QLRQFSHIKMDIILNKPNFAKHIVWAPEDLLPVPLPKPDPVSSINLPLPPLIADQRLNRLWNTKS 914

  Fly   885 HYMPATEIDAAIFSHTPIRWQLHEVTIEESSYAQIRASALHKEQRELRDPRMR-----RILGLPE 944
            .:..|..:|....:...:.....|..:|:|       ..||....:|.|||::     |:..||.
Mouse   915 DHQGALSLDPTSAAKAKLSLTHREGCLEQS-------GDLHSSGGKLGDPRLQKNFDPRLHRLPN 972

  Fly   945 T-------PDNSGPLGSVPI------MGPSSFSVD-NIARCATTIASPDL--------------- 980
            |       .|:.....::|:      :..||.:.. |:|.....:.:|.|
Mouse   973 TESHQVTAKDSHSSRSALPLARWNPALSQSSTAAPINVASVTPPLYAPKLSSEGLPPGTSSSVLS 1037

  Fly   981 -------------------------------ETAVRDSTPSSPPPSVVNLPSMSVPPPSMRVP-- 1012
                                           ::.:::|..:.|.|..|.:|..:.  .::.||
Mouse  1038 GISLYDPRDKGSLSAMELSTISSGENTESQKKSGLKNSDKNQPSPGEVIVPQNTT--ANLEVPVD 1100

  Fly  1013 -PPNIQ---------VEKPTVRT-----------DPRRDPRRAVLQAPTKGASTANTTAPNASGG 1056
             |.::|         |:.|.|.:           .|..|||:|  :.|.:.:.|     |:....
Mouse  1101 GPVDMQTDILRSADKVQVPAVHSLPIQALTGLLRPPYSDPRQA--REPGQASPT-----PDEETD 1158

  Fly  1057 SKQISEI 1063
            .|.:.|:
Mouse  1159 DKPLKEV 1165

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
su(sable)	NP_001284753.1	None
Zc3h6	NP_848491.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..137		37/172 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	179..206		5/26 (19%)
		ZnF_C3H1	274..295	CDD:214632	6/20 (30%)
		ZnF_C3H1	301..325	CDD:214632	12/23 (52%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	383..416		5/47 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	446..587		27/145 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	622..654		7/38 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	670..767		30/131 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	780..826		11/58 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	942..988		13/52 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1043..1101		7/59 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1132..1162		9/36 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	127	1.000	Inparanoid score	I4659
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm43028
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR13119
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4775
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.080