DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment su(sable) and Zc3h4

DIOPT Version :9

Sequence 1:	NP_001284753.1	Gene:	su(sable) / 31012	FlyBaseID:	FBgn0003575	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_006228544.1	Gene:	Zc3h4 / 678741	RGDID:	1596943	Length:	1305	Species:	Rattus norvegicus

Alignment Length:	1510	Identity:	296/1510 - (19%)
Similarity:	453/1510 - (30%)	Gaps:	531/1510 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 VGPSTDAVCLQNSNSTKSK------------KPRPLEDDHASSIELAIANALKKKGIEPPMPRMR 119
            :.||...:||........|            :...||||.|..|:            :.|..:.|
  Rat    30 LSPSQTLLCLLKEMPPTFKDTGAAVWEDGELEEGELEDDGAEDIQ------------DTPGGQER 82

  Fly   120 SSNQDTSDQSLEGSGEGLATANPLLQSTRSSRR--RKRKKEREREQKKDKEQQNRSRR------- 175
            |..:.......:...|            :|.||  ||||||||:|:::.|:::....:
  Rat    83 SRKEKGEKHHSDSDEE------------KSHRRLKRKRKKEREKEKRRSKKRRKSKHKRHASSSD 135

  Fly   176 ------DENDVSVVPGGVEDMDEY--------EMMNVRGGSPPPGGAAPPLSSCGQ--------- 217
                  |::|.|....|.....:|        :..:....:|.|..:...:.|.|.
  Rat   136 DFSDFSDDSDFSPSEKGHRKYRDYSPPYVPSHQQYSSSHNTPLPKKSYSKIDSKGYSMYEDYENE 200

  Fly   218 ---RFSGAD------WDMDD--------------GSAATGAAGLGAG------------------ 241
               .:.|.:      .|.||              .|...|:.|.|.|
  Rat   201 QYGEYEGDEEEDMGKEDYDDFTKELNQYRRAKEGSSRGRGSRGRGRGYRGRGSRGGSRGRGMGRG 265

  Fly   242 ----GGGGYNSH-----------------------SSYDSYSDEETNGPGLMNQRRRTRRDNEKE 279
                |.|....|                       ..||.||.|       :||.||::....:.
  Rat   266 SRGRGRGSMGEHPEDEEDLYDEEIEYGESEEPMGDDDYDEYSKE-------LNQYRRSKDSRGRG 323

  Fly   280 HQRGVNNRKRRDRDRLEGGLAGSGSKRNRR-------------DSGEGGGGG------------Q 319
            ..||.....|..|.:..|...|.||:....             |.|:||||.            .
  Rat   324 LSRGRGRGSRGGRGKGMGRGRGRGSRGGMSKGGMNDEDDFYDDDMGDGGGGSYRRSDHDKPHQQS 388

  Fly   320 EKMGG-------------------SNRVE-PRKLELCKFYLMDCCAKRDKCSYMHKEFPCKYYYL 364
            :|.|.                   |:.:| |:|.||||||:...||:.:.|.|||.:||||.|:.
  Rat   389 DKKGKVICKYFVEGRCTWGDHCNFSHDIELPKKRELCKFYITGFCARAENCPYMHGDFPCKLYHT 453

  Fly   365 GMDCYAGDDCLFYHGEPLSEQLRNVLLKHMETAPKEILGDFKRISRDIAIVQMTRRHEQLCDQLN 429
            ..:|..||||:|.| :||:|:.|.:|       .|.:..|.:..:.|          |:..::|.
  Rat   454 TGNCINGDDCMFSH-DPLTEETRELL-------DKMLADDAEAGAED----------EKEVEELK 500

  Fly   430 RENTWNSI-----GCGLM------------GKRQDHQMQ----------------QQQQQLQHQQ 461
            ::.. |.:     |.||:            .......||                .|.....|:.
  Rat   501 KQGI-NPLPKPPPGVGLLPTPPRPPGPPAPTSPNGRPMQGGPPPPPPPPPPPPGPPQMAMPAHEP 564

  Fly   462 LQQQQEQQQTQQQAAADGGGCIPSLLDMVINPPLSENKRKSRWTEKMGAK--------------- 511
            |..||.||....:.       ||||.::|:.|       ..:..||:|.:
  Rat   565 LSPQQLQQDMYNKK-------IPSLFEIVVRP-------TGQLAEKLGVRFPGPGGPSGPMGPGP 615

  Fly   512 --AAAGAAGSSERDSTSPDAKP-----LPP--HLDLANLSHVLSAENMAK---LN---KLGITNL 561
              ...|..|........||..|     :.|  |.|:....|.....:|..   :|   .:|....
  Rat   616 NMGPPGPMGGPMHPDMHPDMHPDMHPDMHPDMHPDMHPDMHPDMHPDMPMGPGMNPGPPMGPGGP 680

  Fly   562 EQMLQVPFGQLTEAGLTLVEIGEIQRKAEDAKPQTQA-ELESSTPPSKRETEANNSNSKSNGLI- 624
            ..|...| |....:|: :..|...|...|:..||.:. |:|.                   ||:
  Rat   681 PMMPYGP-GDSPHSGM-MAPIPPAQNFYENFYPQQEGMEMEP-------------------GLVG 724

  Fly   625 -MVDYTQYLKDAHVSFSGNDPLDDDRDDDEQLIIDDGNDSTAEEDQQPKK--AKAPPAATHESST 686
             ..||..|                     |:|....|.....|...:|..  ...||......
  Rat   725 DAEDYGHY---------------------EELPGQPGEPLFPEHPLEPDSFPEGGPPGRPKAG-- 766

  Fly   687 EEAPLPSVFDLPSFMNNML-------GQGSSARQLLPASATSPNQENAHLPGGDQSTHKSAPIGG 744
              |.:|..  |||....:.       .:...||:|    |.|..|:..:..|...:.:.|....|
  Rat   767 --AGVPDF--LPSAQRALYLRIQQKQQEEERARRL----AESSKQDRENEEGDTGNWYSSDEDEG 823

  Fly   745 GTSTNVLGRILFGDKQSDPEARAAFYRDIIRNPFKAHSGDGDVDSSNENSNSNSHSLTPTPTPEP 809
            |:|...:.:.|.....|.|:|.       :..|..:..||..:...:   .:......|..:.:|
  Rat   824 GSSVTSILKTLRQQTSSRPQAS-------VGEPSSSGLGDPRLQKGH---TTGGRLADPRLSRDP 878

  Fly   810 ---------GSQSPKPEDHDQDMPELPVIAPALPPTTPSLYVRRSMYDFDPVKEQEHGRQELLTE 865
                     |...|     ....|..|.:|.|||.:.    ...|::..........|:.....|
  Rat   879 RLSRHAETSGGSGP-----GDSGPSDPRLARALPTSK----TEGSLHSSPACPSGSKGQPPAEEE 934

  Fly   866 EKEQYQRDTDMRLPFEPMKHYM---PATEIDAAIFSHTPIRWQLHEVTIEESSYAQIRASALHKE 927
            |.|:..|:..:.:|.:|:..:.   |.:::..  |||..     .:||:.:.|:|
  Rat   935 EGERALREKAVTIPLDPLPGHPLRDPRSQLQQ--FSHIK-----KDVTLSKPSFA---------- 982

  Fly   928 QRELRDPRMRRILGLPETPDNSGPLGSVPIMGPSSFSVDNIARCATTIASPDLETAVRDSTPSSP 992
                     |.:|..||        ..:|:..|.. .|..:.....::  |.|:..:..|||..|
  Rat   983 ---------RTVLWNPE--------DLIPLPIPKQ-DVPPVPAALQSL--PALDPRLHRSTPPGP 1027

  Fly   993 P-----------PSV-------------------VNLPSMSVPP--PSMRVPPPNIQVEKPTVRT 1025
            |           ||.                   ||.|..|..|  |.:|..|.:.:::||.
  Rat  1028 PNTRQQRPGSTDPSTSGSNLPDFELLSRILKTVNVNTPGQSEKPSDPRVRKTPTDPRLQKPA--- 1089

  Fly  1026 DPRRDP---RRAVLQAPTKGASTANTTAPNASGGSKQISEIRSLLQVSNWYNNLGTNNKIMVNQQ 1087
                ||   .||....||:    |:..|.:.||.|...:
  Rat  1090 ----DPGAASRAAKPCPTE----ASPPAASPSGDSPPAT-------------------------- 1120

  Fly  1088 LALVFTELKKFHQLPNDAPKIFDVSFIVNNTTLQQIFAKLFIFVDDNGEVVQIPEEPNGNGAALG 1152
                         .|.| |::.....:...::..|......|.:.|       |..||..|....
  Rat  1121 -------------APYD-PRVLAAGGLGQGSSSGQSSVLSGISLYD-------PRTPNAGGKTAE 1164

  Fly  1153 GGGDSGGGVGGGGGGGGVVLPNLSQPPPNLSQMLRLPPPNIRMLRMSGMMMQMGNVGP----PFN 1213
            ...|:.....|..|.|........:||......|..|.        :|.....|....    .:|
  Rat  1165 LTSDTSAQPKGPEGNGKSSASKAKEPPFVRKSALEQPE--------TGKASTDGATATDRYNSYN 1221

  Fly  1214 QPPPR------GGLMGMPPNGNGLNQGVGNLGGLGQLGINQGGGPVPNGNPFNPFGGNNGGGAGV 1272
            :|.|:      ......||.|.....||.||......|..:   |.|.....:||.||:....|
  Rat  1222 RPRPKATAAPTAASSTPPPEGATTQPGVHNLPVPTLFGTVK---PTPKTGTGSPFAGNSPAREG- 1282

  Fly  1273 MNNMNSMGNMGMGFN 1287
            ..:..|:.::..||:
  Rat  1283 EQDAGSLKDVFKGFD 1297

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
su(sable)	NP_001284753.1	None
Zc3h4	XP_006228544.1	ZnF_C3H1	394..415	CDD:214632	1/20 (5%)
		ZnF_C3H1	421..445	CDD:214632	13/23 (57%)
		OmdA	<774..799	CDD:290113	5/28 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm45093
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13119
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.100