Protein Alignment su(sable) and ZC3H6

DIOPT Version :10

• Sequence 1: NP_476754.1
• Gene: su(sable) / 31012
• FlyBaseID: FBgn0003575
• Length: 1325
• Species: Drosophila melanogaster
• Sequence 2: NP_940983.2
• Gene: ZC3H6 / 376940
• HGNCID: 24762
• Length: 1189
• Species: Homo sapiens
• Alignment Length: 1336
• Identity: 285/1336 - (21%)
• Similarity: 429/1336 - (32%)
• Gaps: 472/1336 - (35%)

  Fly    16 DLEDGEIDDDEEDEQQSSKIQVQKKTFVGDDDVQFVGVEAK-NQNDDEDVVYVGPSTDAVCLQNS 79
            |.||||::|.|.|:....:||.:               ||| |:....:..|           ..
Human    10 DREDGELEDGEIDDAGFEEIQEK---------------EAKENEKQKSEKAY-----------RK 48

  Fly    80 NSTKSKKPRPLEDDHASSIELAIANALKKKGIEPPMPRMRSSNQDTSDQSLEGSGEGLATANPLL 144
            :..|.||.|..:.......|       |.|...|       |:.|:||.||:..          :
Human    49 SRKKHKKEREKKKSKRRKRE-------KHKHNSP-------SSDDSSDYSLDSD----------V 89

  Fly   145 QSTRSSRRRK-----------------------RKKEREREQKKDKEQQNRSR-RDEN-----DV 180
            :.|.||.:::                       .||.:..::.|.||....|. .|:|     |.
Human    90 EHTESSHKKRTGFYRDYDIPFTQRGHISGSYITSKKGQHNKKFKSKEYDEYSTYSDDNFGNYSDD 154

  Fly   181 SVVPGGVEDMDEY-----------EMMNVRGGSPPPGGAAPPLSSCGQRFSGADWDMDDGSAATG 234
            :....|.|..:::           |..|:..||     :....|...||..|....::. ...:.
Human   155 NFGNYGQETEEDFANQLKQYRQAKETSNIALGS-----SFSKESGKKQRMKGVQQGIEQ-RVKSF 213

  Fly   235 AAGLGAG---------GGGGYNSHSSYDSYSD--EETNGPG----LMNQRRRTRRDNEKEHQRGV 284
            ..|.|.|         .||..|...:..|.||  :|.|.||    :|.|        |..:|..|
Human   214 NVGRGRGLPKKIKRKERGGRTNKGPNVFSVSDDFQEYNKPGKKWKVMTQ--------EFINQHTV 270

  Fly   285 NNR-KRRDRDRLEGGLAGSGSKRNRRDSGEGGGGGQEKMGGSNRVEPRKLELCKFYLMDCCAKRD 348
            .:: |:..:..|||...               .|.|.|......:|.|| |:|||||...|.|.:
Human   271 EHKGKQICKYFLEGRCI---------------KGDQCKFDHDAELEKRK-EICKFYLQGYCTKGE 319

  Fly   349 KCSYMHKEFPCKYYYLGMDCYAGDDCLFYHGEPLSEQLRNVLLKHMETAPKEILGDFKRISRDIA 413
            .|.|||.|||||:|:.|..||.||:|.|.| :.|:::.:.:|.|.:.|       |.:.|:.|
Human   320 NCIYMHNEFPCKFYHSGAKCYQGDNCKFSH-DDLTKETKKLLDKVLNT-------DEELINED-- 374

  Fly   414 IVQMTRRHEQLCDQLNRENTWNSI-----GCGLMGKRQDHQMQQQQQQLQHQQLQQQQEQQQTQQ 473
                .|..|:|     |:.....:     |.||:           ....:|......::..||.
Human   375 ----ERELEEL-----RKRGITPLPKPPPGVGLL-----------PTPPEHFPFSDPEDDFQTD- 418

  Fly   474 QAAADGGGCIPSLLDMVINPPLSENKRKSRWTEKMGAKAAAGAAGSSERDSTSPDAKPLPPHLDL 538
              .:|....||||.::|:.|.:.       ...|:|.|..|....:|........:.|.|.|: .
Human   419 --FSDDFRKIPSLFEIVVKPTVD-------LAHKIGRKPPAFYTSASPPGPQFQGSSPHPQHI-Y 473

  Fly   539 ANLSHVLSAENMAKLNKLGITN----------------LEQMLQVPFGQLTEAGLTLVEIGEIQR 587
            ::.|......||::.:...:.:                :.|...:|.|
Human   474 SSGSSPGPGPNMSQGHSSPVMHPGSPGHHPCAGPPGLPVPQSPPLPPG----------------- 521

  Fly   588 KAEDAKPQTQAEL-----ESSTPPSKRETEANNSNSKSNGLIMVDYTQYLKDAHVSFSGNDPLDD 647
            ..|...||.||.:     .|.||||.      .....|.|.          ..||.
Human   522 PPEIVGPQNQAGVLVQPDTSLTPPSM------GGAYHSPGF----------PGHVM--------- 561

  Fly   648 DRDDDEQLIIDDGNDSTAEEDQQPKKAKAPPAATHESSTEEAPL----PSVFDLPSFMNNMLGQ- 707
                                 :.|::....|.::::.|..|..|    .|:.:...|.:|...|
Human   562 ---------------------KVPRENHCSPGSSYQQSPGEMQLNTNYESLQNPAEFYDNYYAQH 605

  Fly   708 -----------------GSSARQLLPASATSPNQENAHLPGGDQST----HKSAPIGGGTSTNVL 751
                             |..|:|..|....|||    |..|.|.|:    |...|:.|  ....:
Human   606 SIHNFQPPNNSGDGMWHGEFAQQQPPVVQDSPN----HGSGSDGSSTRTGHGPLPVPG--LLPAV 664

  Fly   752 GRILF----GDKQSDPEARAAFYRDIIRNPFKAHSGDGD-----VDSSNENSNSNSHSLTPTPTP 807
            .|.||    ...|.|.|..:.       .|.:|.|.:.|     ..||.|...|:..|:..|..
Human   665 QRALFVRLTQRYQEDEEQTST-------QPHRAPSKEEDDTVNWYSSSEEEEGSSVKSILKTLQ- 721

  Fly   808 EPGSQSPKPEDHDQDMPELPVIAPALPPTTPSLYVRRSMYDFDPVKEQEHGRQ----ELLTEEKE 868
               .|:....:..|...||..      ||.|.|           .||:..|.|    .|.|..::
Human   722 ---KQTETLRNQQQPSTELST------PTDPRL-----------AKEKSKGNQVVDPRLRTIPRQ 766

  Fly   869 QYQRDT-----DMRLPFEPMK-------HYMPATEIDAAIFSHTPIRWQLHEVTIEESSYAQIRA 921
            ..::.:     |:||.::|.|       |.  .:.:..|       ::.||        :|....
Human   767 DIRKPSESAPLDLRLAWDPRKLRGNGSGHI--GSSVGGA-------KFDLH--------HANAGT 814

  Fly   922 SALHKE--------QRELRDPRMRRILGLPETPDNSGPLGSVPIMGPSS----FSVDNIARCATT 974
            :..||.        :||||:...  ::.|..:|       .:.:..|.|    ||   ..:...|
Human   815 NVKHKRGDDDDEDTERELREKAF--LIPLDASP-------GIMLQDPRSQLRQFS---HIKMDIT 867

  Fly   975 IASPDL--------ETAVRDSTPSSPPPSVVNLPSMSVPPPSM------RVPPPNIQVEKPTVRT 1025
            :..|:.        |..:....|...|.|.:|||.    ||.:      |:......:.:.||..
Human   868 LTKPNFAKHIVWAPEDLLPVPLPKPDPVSSINLPL----PPLIADQRLNRLWNTKSDLHQNTVSI 928

  Fly  1026 DPRRDPRRAVLQAPTKGASTANTTAPNASGGSKQISEIRSLLQVSNWYNNLGTNNKIMVNQQLAL 1090
            ||:       |.|..|    .|||  |..|..:|..:            :.|:..| :.:.:|..
Human   929 DPK-------LAAKAK----INTT--NREGYLEQFGD------------SHGSGAK-LGDPRLQK 967

  Fly  1091 VFTELKKFHQLPNDAPKIFDVSFIVNNTTLQQIFAKLFIFVDDNGEVVQIPEEPNGNGAALGGGG 1155
            .|.  .:.|:||              ||...|:..|      |:......|..|..|.   |...
Human   968 NFD--PRLHRLP--------------NTESHQVVMK------DSHASKGAPHLPRSNP---GSSQ 1007

  Fly  1156 DSGGGVGGGGGGGGVVLPNLSQPP--PNLSQMLRLP 1189
            .||.|....|.|        :.||  |.||....||
Human  1008 PSGAGTSNSGSG--------ALPPYAPKLSSSAGLP 1035

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
su(sable)	NP_476754.1	None
ZC3H6	NP_940983.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..105		32/144 (22%)
		zf_CCCH_4	278..296	CDD:465719	6/32 (19%)
		zf-CCCH_3	300..>359	CDD:464787	30/60 (50%)
		zf_CCCH_4	307..325	CDD:465719	9/17 (53%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	451..530		12/96 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	630..659		10/32 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	676..755		24/106 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	947..1026		24/124 (19%)
		PHA03307	<1006..>1162	CDD:223039	12/38 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1051..1189