DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment su(sable) and Zc3h4

DIOPT Version :9

Sequence 1:	NP_001284753.1	Gene:	su(sable) / 31012	FlyBaseID:	FBgn0003575	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_006540165.1	Gene:	Zc3h4 / 330474	MGIID:	2682314	Length:	1304	Species:	Mus musculus

Alignment Length:	1575	Identity:	308/1575 - (19%)
Similarity:	464/1575 - (29%)	Gaps:	624/1575 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 IDLEEDLEDGEIDDDEEDEQQSSKIQVQKKTFVGDDDVQFVGVEAKNQNDDEDVVYVGPSTDAVC 75
            :.|.:|.||||:::.|
Mouse    48 LPLPDDREDGELEEGE------------------------------------------------- 63

  Fly    76 LQNSNSTKSKKPRPLEDDHASSIELAIANALKKKGIEPPMPRMRSSNQDTSDQSLEGSGEGLATA 140
                          ||||.|..::            :||..:.||..:.......:...|
Mouse    64 --------------LEDDGAEEVQ------------DPPGGQERSRKEKGEKHHSDSEEE----- 97

  Fly   141 NPLLQSTRSSRR--RKRKKEREREQKKDKEQQNRSRR-------DENDVSVVPGGVEDMD----E 192
                   :|.||  ||||||||:|:::.|:::....:       |.:|.|      :|.|    |
Mouse    98 -------KSHRRLKRKRKKEREKEKRRSKKRRKSKHKRHASSSDDFSDFS------DDSDFSPSE 149

  Fly   193 YEMMNVRGGSPP----------------PGGAAPPLSSCGQ------------RFSGAD------ 223
            ......|..|||                |..:...:.|.|.            .:.|.:
Mouse   150 KSHRKYRDYSPPYAPSHQQYSSSHNAPLPKKSYSKMDSKGYSMYEDYENEQYGEYEGDEEEDMGK 214

  Fly   224 WDMDD--------------GSAATGAAGLGAG----------------------GGGGYNSH--- 249
            .|.||              .|...|:.|.|.|                      |.|....|
Mouse   215 EDYDDFTKELNQYRRAKEGSSRGRGSRGRGRGYRGRGSRGGSRGRGMGRGSRGRGRGSMGEHPED 279

  Fly   250 --------------------SSYDSYSDEETNGPGLMNQRRRTR--RDNEKEHQRGVNNR----K 288
                                ..||.||.|       :||.||::  |.......||..:|    |
Mouse   280 EEDLYEEEIEYGESEEPMGDDDYDDYSKE-------LNQYRRSKDSRGRGLSRGRGRGSRGGRGK 337

  Fly   289 RRDRDRLEGGLAGSGSKRNRRDS--------GEGGGGG------------QEKMGG--------- 324
            ...|.|..||..|. ||....|.        |:||||.            .:|.|.
Mouse   338 GMGRGRGRGGRGGM-SKGGMNDDEDFYDDDMGDGGGGSYRRSDHDKPHQQSDKKGKVICKYFVEG 401

  Fly   325 ----------SNRVE-PRKLELCKFYLMDCCAKRDKCSYMHKEFPCKYYYLGMDCYAGDDCLFYH 378
                      |:.:| |:|.||||||:...||:.:.|.|||.:||||.|:...:|..||||:|.|
Mouse   402 RCTWGDHCNFSHDIELPKKRELCKFYITGFCARAENCPYMHGDFPCKLYHTTGNCINGDDCMFSH 466

  Fly   379 GEPLSEQLRNVLLKHMETAPKEILGDFKRISRDIAIVQMTRRHEQLCDQLNRENTWNSI-----G 438
             :||:|:.|.:|       .|.:..|.:..:.|          |:..::|.::.. |.:     |
Mouse   467 -DPLTEETRELL-------DKMLADDAEAGAED----------EKEVEELKKQGI-NPLPKPPPG 512

  Fly   439 CGLM------------GKRQDHQMQ----------------QQQQQLQHQQLQQQQEQQQTQQQA 475
            .||:            .......||                .|.....|:.|..||.||....:.
Mouse   513 VGLLPTPPRPPGPPAPTSPNGRPMQGGPPPPPPPPPPPPGPPQMSLPTHEPLSPQQLQQDMYNKK 577

  Fly   476 AADGGGCIPSLLDMVINPPLSENKRKSRWTEKMGAK-----------------AAAGAAGSSERD 523
                   ||||.::|:.|       ..:..||:|.:                 ...|..|.....
Mouse   578 -------IPSLFEIVVRP-------TGQLAEKLGVRFPGPGGPSGPMGPGPNMGPPGPMGGPMHP 628

  Fly   524 STSPDAKP-----LPP--HLDLANLSHVLSAENMAK---LN---KLGITNLEQMLQVPFGQLTEA 575
            ...||..|     :.|  |.|:....|.....:|..   :|   .:|......|...| |....:
Mouse   629 DMHPDMHPDMHPDMHPDMHPDMHPDMHPDMHPDMPMGPGMNPGPPMGPGGPPMMPYGP-GDSPHS 692

  Fly   576 GLTLVEIGEIQRKAEDAKPQTQA-ELESSTPPSKRETEANNSNSKSNGLI--MVDYTQYLKDAHV 637
            |: :..|...|...|:..||.:. |:|.                   ||:  ..||..|
Mouse   693 GM-MPPIPPAQNFYENFYPQQEGMEMEP-------------------GLVGDAEDYGHY------ 731

  Fly   638 SFSGNDPLDDDRDDDEQLIIDDGNDSTAEEDQQPKK--AKAPPAATHESSTEEAPLPSVFDLPSF 700
                           |:|....|.....|...:|..  ...||......    |.:|..  |||.
Mouse   732 ---------------EELPGQPGEPLFPEHPLEPDSFPEGGPPGRPKAG----AGVPDF--LPSA 775

  Fly   701 MNNML-------GQGSSARQLLPASATSPNQENAHLPGGDQSTHKSAPIGGGTSTNVLGRILFGD 758
            ...:.       .:...||:|    |.|..|:..:..|...:.:.|....||:|...:.:.|...
Mouse   776 QRALYLRIQQKQQEEERARRL----AESSKQDRENEEGDTGNWYSSDEDEGGSSVTSILKTLRQQ 836

  Fly   759 KQSDPEARAAFYRDIIRNPFKAHSGDGDVDSSNENSNSNSHSLTPTPTPEPG-SQSPKPEDHDQD 822
            ..|.|:|.       :..|..:..||..:...:...:..|         :|. |:.|:...|.:.
Mouse   837 TSSRPQAS-------VGEPSSSGLGDPRLQKGHPTGSRLS---------DPRLSRDPRLSRHAET 885

  Fly   823 M---------PELPVIAPALPPTTPSLYVRRSMYDFDPVKEQEHGRQELLTEEKEQYQRDTDMRL 878
            .         |..|.:|.|||.:.    ...|::..........|:.....||.|:..|:..:.:
Mouse   886 SGGSGPGDSGPSDPRLARALPTSK----AEGSLHSSPAGPSSSKGQPPAEEEEGERALREKAVNI 946

  Fly   879 PFEPMKHYM---PATEIDAAIFSHTPIRWQLHEVTIEESSYAQIRASALHKEQRELRDPRMRRIL 940
            |.:|:..:.   |.:::..  |||..     .:||:.:.|:|                   |.:|
Mouse   947 PLDPLPGHPLRDPRSQLQQ--FSHIK-----KDVTLSKPSFA-------------------RTVL 985

  Fly   941 GLPETPDNSGPLGSVPIMGPSSFSVDNIARCATTIASPDLETAVRDSTPSSPP----------PS 995
            ..||        ..:|:..|.. .|..:.....::  |.|:..:..|||..||          ||
Mouse   986 WNPE--------DLIPLPIPKQ-DVPPVPAALQSL--PALDPRLHRSTPPGPPNTRQRPGSTDPS 1039

  Fly   996 V-------------------VNLPSMSVPP--PSMRVPPPNIQVEKPTVRTDPRRDP---RRAVL 1036
            .                   ||.|..|..|  |.:|..|.:.:::||.       ||   .||..
Mouse  1040 TSGSNLPDFELLSRILKTVNVNTPGQSEKPSDPRVRKTPTDPRLQKPA-------DPVAASRAAK 1097

  Fly  1037 QAPTK---------GASTANTTAPN-----ASGGSKQISEIRSLLQVSNWYNNLGTNNKIMVNQQ 1087
            ..||:         |.|:...|||.     |:||..|                 |:::
Mouse  1098 PCPTEASPPAASPSGDSSPPATAPYDPRVLAAGGLGQ-----------------GSSS------- 1138

  Fly  1088 LALVFTELKKFHQLPNDAPKIFDVSFIVNNTTLQQIFAKLFIFVDDNGEVVQIPEEPNGNGAALG 1152
                                  ..|.:::..:|..                  |..||..|....
Mouse  1139 ----------------------GQSSVLSGISLYD------------------PRTPNAGGKTAE 1163

  Fly  1153 GGGDSGGGVGGGGGGGGVVLPNLSQPPPNLSQMLRLPPPNIRMLRMSGMMMQMGNVGP----PFN 1213
            ...|:.....|..|.|........:||......|..|.        :|.....|....    .:|
Mouse  1164 PASDTSAQPKGPEGNGKGSASKAKEPPFVRKSALEQPE--------TGKASTDGATATDRYNSYN 1220

  Fly  1214 QPPPR------GGLMGMPPNGNGLNQGVGNLGGLGQLGINQGGGPVPNGNPFNPFGGNNGGGAGV 1272
            :|.|:      ......||.|.....||.||......|..:   |.|.....:||.||:....|
Mouse  1221 RPRPKATAAPTAASSTPPPEGATPQPGVHNLPVPTLFGTVK---PAPKTGTGSPFAGNSPAREG- 1281

  Fly  1273 MNNMNSMGNMGMGFN 1287
            ..:..|:.::..||:
Mouse  1282 EQDAGSLKDVFKGFD 1296

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
su(sable)	NP_001284753.1	None
Zc3h4	XP_006540165.1	zf-CCCH_4	393..414	CDD:375512	1/20 (5%)
		ZnF_C3H1	420..444	CDD:214632	13/23 (57%)
		zf-CCCH	446..467	CDD:366217	11/21 (52%)
		PHA03247	<732..1129	CDD:223021	94/470 (20%)
		OmdA	<773..798	CDD:379149	5/28 (18%)
		PHA03247	<993..1279	CDD:223021	71/370 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	127	1.000	Inparanoid score	I4659
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm43028
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13119
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4775
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.080