DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment su(sable) and ZC3H4

DIOPT Version :9

Sequence 1:	NP_001284753.1	Gene:	su(sable) / 31012	FlyBaseID:	FBgn0003575	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_055983.1	Gene:	ZC3H4 / 23211	HGNCID:	17808	Length:	1303	Species:	Homo sapiens

Alignment Length:	1580	Identity:	312/1580 - (19%)
Similarity:	467/1580 - (29%)	Gaps:	634/1580 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 PLIDLEED--LEDGEIDDDEEDEQQSSKIQVQKKTFVGDDDVQFVGVEAKNQNDDEDVVYVGPST 71
            ||.|..||  ||:||::||..:|.|.:.                                .||
Human    49 PLPDDREDGELEEGELEDDGAEETQDTS--------------------------------GGP-- 79

  Fly    72 DAVCLQNSNSTKSKKPRPLEDDHASSIELAIANALKKKGIEPPMPRMRSSNQDTSDQSLEGSGEG 136
                 :.|...|.:|       |.|                       .|:::.|.:.|
Human    80 -----ERSRKEKGEK-------HHS-----------------------DSDEEKSHRRL------ 103

  Fly   137 LATANPLLQSTRSSRRRKRKKEREREQKKDKEQQNRSRR-------------DENDVSVVPGGVE 188
                           :||||||||:|:::.|:::....:             |::|.|....|..
Human   104 ---------------KRKRKKEREKEKRRSKKRRKSKHKRHASSSDDFSDFSDDSDFSPSEKGHR 153

  Fly   189 DMDEYEMMNVRGGSPP--------PGGAAPPL----------SSCGQ----------RFSGAD-- 223
            ...||        |||        |...|.||          .|.|.          .:.|.:
Human   154 KYREY--------SPPYAPSHQQYPPSHATPLPKKAYSKMDSKSYGMYEDYENEQYGEYEGDEEE 210

  Fly   224 ----WDMDD-------------GSA--------------------------ATGAAGLGAGGGGG 245
                .|.||             ||:                          ..|:.|.|.|..||
Human   211 DMGKEDYDDFTKELNQYRRAKEGSSRGRGSRGRGRGYRGRGSRGGSRGRGMGRGSRGRGRGSMGG 275

  Fly   246 YNSHSSYDSYSDEETNGPG--------------LMNQRRRTRRDNEKEHQRGVNNRKRRDRDRLE 296
            .:.....|.|.:|...|..              .:||.||::....:...||   |.|..|.|.:
Human   276 DHPEDEEDFYEEEMDYGESEEPMGDDDYDEYSKELNQYRRSKDSRGRGLSRG---RGRGSRGRGK 337

  Fly   297 G-----GLAGSGSKRNR-----------RDSGEGGGGG------------QEKMGG--------- 324
            |     |..||....|:           .|.|:||||.            .:|.|.
Human   338 GMGRGRGRGGSRGGMNKGGMNDDEDFYDEDMGDGGGGSYRSRDHDKPHQQSDKKGKVICKYFVEG 402

  Fly   325 ----------SNRVE-PRKLELCKFYLMDCCAKRDKCSYMHKEFPCKYYYLGMDCYAGDDCLFYH 378
                      |:.:| |:|.||||||:...||:.:.|.|||.:||||.|:...:|..||||:|.|
Human   403 RCTWGDHCNFSHDIELPKKRELCKFYITGFCARAENCPYMHGDFPCKLYHTTGNCINGDDCMFSH 467

  Fly   379 GEPLSEQLRNVLLKHMETAPKEILGDFKRISRDIAIVQMTRRHEQLCDQLNRENTWNSI-----G 438
             :||:|:.|.:|       .|.:..|.:..:.|          |:..::|.::.. |.:     |
Human   468 -DPLTEETRELL-------DKMLADDAEAGAED----------EKEVEELKKQGI-NPLPKPPPG 513

  Fly   439 CGLM-------GKR-----QDHQMQ----------------QQQQQLQHQQLQQQQEQQQTQQQA 475
            .||:       |.:     ....||                .|.....|:.|..||.|||.....
Human   514 VGLLPTPPRPPGPQAPTSPNGRPMQGGPPPPPPPPPPPPGPPQMPMPVHEPLSPQQLQQQDMYNK 578

  Fly   476 AADGGGCIPSLLDMVINPPLSENKRKSRWTEKMGAKAAAGAAGSSERDSTSPDAKPL-----PPH 535
            .      ||||.::|:.|       ..:..||:|.: ..|..|........|:..|.     |.|
Human   579 K------IPSLFEIVVRP-------TGQLAEKLGVR-FPGPGGPPGPMGPGPNMGPPGPMGGPMH 629

  Fly   536 LDLANLSHVLSAENMAKLNKLGITNLEQMLQVPFG-------QLTEAGLTLVEIGEIQRKAEDAK 593
            .|:....|.....:|         :.:....:|.|       .:...|..::..|..........
Human   630 PDMHPDMHPDMHPDM---------HADMHADMPMGPGMNPGPPMGPGGPPMMPYGPGDSPHSGMM 685

  Fly   594 PQTQAELESSTPPSKRETEANNSNSKSNGLIM--------VDYTQYLKDAHVSFSGNDPLDDDRD 650
            |        ..||::...|  |...:..|:.|        .||..|
Human   686 P--------PIPPAQNFYE--NFYQQQEGMEMEPGLLGDAEDYGHY------------------- 721

  Fly   651 DDEQLIIDDGNDSTAEEDQQPKKAK--APPAATHESSTEEAPLPSVFDLPSFM------------ 701
              |:|..:.|.....|...:|....  .||.         .|.|.. .:|.|:
Human   722 --EELPGEPGEHLFPEHPLEPDSFSEGGPPG---------RPKPGA-GVPDFLPSAQRALYLRIQ 774

  Fly   702 NNMLGQGSSARQLLPASATSPNQENAHLPGGDQSTHKSAPIGGGTSTNVLGRILFGDKQSDPEAR 766
            .....:...||:|    |.|..|:..:..|...:.:.|....||:|...:.:.|.....|.|.|.
Human   775 QKQQEEEERARRL----AESSKQDRENEEGDTGNWYSSDEDEGGSSVTSILKTLRQQTSSRPPAS 835

  Fly   767 AAFYRDIIRNPFKAHSGDGDVDSSNENSNSNSHSLTPTPTPEP-------GSQSPKPEDHDQDMP 824
            ....         :.||.|| ....:...:.|....|..:.:|       .|....|.|..   |
Human   836 VGEL---------SSSGLGD-PRLQKGHPTGSRLADPRLSRDPRLTRHVEASGGSGPGDSG---P 887

  Fly   825 ELPVIAPALPPTTPSLYVRRSMYDFDPVKEQEHGRQELLTEEKEQYQRDTDMRLPFEPMKHYM-- 887
            ..|.:|.|||.:.|...:..|  ...|...:..|......||.|:..|:..:.:|.:|:..:.
Human   888 SDPRLARALPTSKPEGSLHSS--PVGPSSSKGSGPPPTEEEEGERALREKAVNIPLDPLPGHPLR 950

  Fly   888 -PATEIDAAIFSHTPIRWQLHEVTIEESSYAQIRASALHKEQRELRDPRMRRILGLPE------- 944
             |.:::..  |||..     .:||:.:.|:|                   |.:|..||
Human   951 DPRSQLQQ--FSHIK-----KDVTLSKPSFA-------------------RTVLWNPEDLIPLPI 989

  Fly   945 -----TPDNSGPLGSVPIMGPSSFSVDNIARCAT-------------TIAS------PDLETAVR 985
                 .|.....|.|:|.:.|      .:.|.||             |.:|      ||.|...|
Human   990 PKQDAVPPVPAALQSMPTLDP------RLHRAATAGPPNARQRPGASTDSSTQGANLPDFELLSR 1048

  Fly   986 -----DSTPSSPPPSVVNLPSMSVPPPSMRVPPPNIQVEKPTVRTDPRRDPRRAVLQAPTKGAST 1045
                 ::|.||..|...:.||    .|.:|..|.:.:::|||..|...|..:....:||:..||.
Human  1049 ILKTVNATGSSAAPGSSDKPS----DPRVRKAPTDPRLQKPTDSTASSRAAKPGPAEAPSPTASP 1109

  Fly  1046 ANTTAPNAS----------------GGSKQISEIRSLLQVSNWYNNLGTNNKIMVNQQLALVFTE 1094
            :...:|.|:                ||..|.|.:..:
Human  1110 SGDASPPATAPYDPRVLAAGGLGQGGGGGQSSVLSGI---------------------------- 1146

  Fly  1095 LKKFHQLPNDAPKIFDVSFIVNNTTLQQIFAKLFIFVDDNGEVVQIPEEPNGNGAALGGGGDSGG 1159
                        .::|                              |..||..|.|.....|:|.
Human  1147 ------------SLYD------------------------------PRTPNAGGKATEPAADTGA 1169

  Fly  1160 GVGGGGGGGGVVLPNLSQPPPNLSQMLRLPPPNIRMLRMSGMMMQMGNVGP----------PFNQ 1214
            ...|..|.|........:||......|..|              :.|..|.          .:|:
Human  1170 QPKGAEGNGKSSASKAKEPPFVRKSALEQP--------------ETGKAGADGGTPTDRYNSYNR 1220

  Fly  1215 PPPRGGLMGM------PPNGNGLNQGVGNL------GGLGQLGINQGGGPVPNGNPFNPFGGNNG 1267
            |.|:......      ||.|.....||.||      |.:.|         .|.....:||.||:.
Human  1221 PRPKAAAAPAATTATPPPEGAPPQPGVHNLPVPTLFGTVKQ---------TPKTGSGSPFAGNSP 1276

  Fly  1268 GGAGVMNNMNSMGNMGMGFN 1287
            ...| ..:..|:.::..||:
Human  1277 AREG-EQDAASLKDVFKGFD 1295

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
su(sable)	NP_001284753.1	None
ZC3H4	NP_055983.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..388		85/439 (19%)
		ZnF_C3H1	394..415	CDD:214632	1/20 (5%)
		ZnF_C3H1	421..445	CDD:214632	13/23 (57%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	486..571		15/95 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	605..685		12/88 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	710..955		56/294 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	996..1288		74/395 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	132	1.000	Inparanoid score	I4622
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40959
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13119
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4775
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	5.080