Protein Alignment Dredd and CASP10

DIOPT Version :9

• Sequence 1: NP_477249.3
• Gene: Dredd / 31011
• FlyBaseID: FBgn0020381
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: NP_116759.2
• Gene: CASP10 / 843
• HGNCID: 1500
• Length: 522
• Species: Homo sapiens
• Alignment Length: 575
• Identity: 133/575 - (23%)
• Similarity: 217/575 - (37%)
• Gaps: 185/575 - (32%)

  Fly    18 LIYVERDMNFAQKVGLCFLLYG-------DDHSDATYILQKLLAMTRSDFPQSDLLIKFAKSRPE 75
            |:.::.::.......|.||..|       :..|.|:.:.:.|||        .|||     |..:
Human    24 LLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASDVFEHLLA--------EDLL-----SEED 75

  Fly    76 TWRRHLVEALCIIGARKVLRRLGFCWQELRMHYLPHIAGITLHVHPLLKSLYRMCEELSLVQSGR 140
            .:  .|.|.|.||..:|:|:.|. |.:|.....||....:         ||:|           .
Human    76 PF--FLAELLYIIRQKKLLQHLN-CTKEEVERLLPTRQRV---------SLFR-----------N 117

  Fly   141 LLLDVREKVESQQAGDPLRFYDPAYLEIFLL-DWLTRRSI----------KLGDIN--------- 185
            ||.::.|.::|:...|          .|||| |.|.:..:          |.|.|:
Human   118 LLYELSEGIDSENLKD----------MIFLLKDSLPKTEMTSLSFLAFLEKQGKIDEDNLTCLED 172

  Fly   186 ------------------------------------------AAGSDVQLLV----------GHL 198
                                                      .:.:||:..:          .|.
Human   173 LCKTVVPKLLRNIEKYKREKAIQIVTPPVDKEAESYQGEEELVSQTDVKTFLEALPQESWQNKHA 237

  Fly   199 KSNGLQAQANLLKDTIISNAPEPDAAGTAAMAVKQEIESDNQQSYCSTQIDALKLTRENAGIALI 263
            .|||.:|...  ..:::|...:    |.:|..:..|..:.....|        ::.|.:.|:.:|
Human   238 GSNGNRATNG--APSLVSRGMQ----GASANTLNSETSTKRAAVY--------RMNRNHRGLCVI 288

  Fly   264 INQQKFHRNVSRDNMKFLSPDPLRRRDGTDVDKERLIEVFSSMGYNVEAYDNVDHMGIIERI--R 326
            :|...|              ..|:.|.||..|.|.|..||..:|:.|..::||..:. :|.:  :
Human   289 VNNHSF--------------TSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVE-MEMVLQK 338

  Fly   327 SACDRSLVRDSLVVF-ILSHGFEEAVYASNSIAMKITDIED----LLCSYDTLYYKPKLLIIQAC 386
            ..|:.:.......|| ||:||...|||:|:...:.|.:|..    |.|  ..|..||||..||||
Human   339 QKCNPAHADGDCFVFCILTHGRFGAVYSSDEALIPIREIMSHFTALQC--PRLAEKPKLFFIQAC 401

  Fly   387 QEKLVHKKKPNELFRIDVTTVSPDQ-----------HIDMLRAMSTVNGYAALRHTQTGSWFIGS 440
            |.:.:   :|:  ..|:...::|:|           ..|.|..::||.||.:.||.:.|||:|.|
Human   402 QGEEI---QPS--VSIEADALNPEQAPTSLQDSIPAEADFLLGLATVPGYVSFRHVEEGSWYIQS 461

  Fly   441 LCDAIDRR-SASEHIADILTIVTNEVSK---KRGSNDESMVPNVKSTFRQHVYFP 491
            ||:.:.:. ...|.|..|||.|.::||:   |:|:  :..:|....|.|:.:.||
Human   462 LCNHLKKLVPRHEDILSILTAVNDDVSRRVDKQGT--KKQMPQPAFTLRKKLVFP 514

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dredd	NP_477249.3	CASc	252..492	CDD:294037	78/262 (30%)
CASP10	NP_116759.2	DD	18..99	CDD:326335	23/90 (26%)
		DED_Caspase_10_r2	112..190	CDD:260074	17/107 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	231..269		9/43 (21%)
		CASc	276..514	CDD:214521	77/269 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144829
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3573
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	4	3.700