Protein Alignment Dredd and CASP10

DIOPT Version :10

• Sequence 1: NP_477249.3
• Gene: Dredd / 31011
• FlyBaseID: FBgn0020381
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: NP_116759.2
• Gene: CASP10 / 843
• HGNCID: 1500
• Length: 522
• Species: Homo sapiens
• Alignment Length: 576
• Identity: 136/576 - (23%)
• Similarity: 219/576 - (38%)
• Gaps: 187/576 - (32%)

  Fly    18 LIYVERDMNFAQKVGLCFLLYG-------DDHSDATYILQKLLAMTRSDFPQSDLLIKFAKSRPE 75
            |:.::.::.......|.||..|       :..|.|:.:.:.|||        .|||     |..:
Human    24 LLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASDVFEHLLA--------EDLL-----SEED 75

  Fly    76 TWRRHLVEALCIIGARKVLRRLGFCWQELRMHYLPHIAGITLHVHPLLKSLYRMCEELSLVQSGR 140
            .:  .|.|.|.||..:|:|:.|. |.:|.....||....:         ||:|           .
Human    76 PF--FLAELLYIIRQKKLLQHLN-CTKEEVERLLPTRQRV---------SLFR-----------N 117

  Fly   141 LLLDVREKVESQQAGDPLRFYDPAYLEIFLL-DWLTRRSI----------KLGDIN--------- 185
            ||.::.|.::|:...|          .|||| |.|.:..:          |.|.|:
Human   118 LLYELSEGIDSENLKD----------MIFLLKDSLPKTEMTSLSFLAFLEKQGKIDEDNLTCLED 172

  Fly   186 ------------------------------------------AAGSDVQLLV----------GHL 198
                                                      .:.:||:..:          .|.
Human   173 LCKTVVPKLLRNIEKYKREKAIQIVTPPVDKEAESYQGEEELVSQTDVKTFLEALPQESWQNKHA 237

  Fly   199 KSNGLQAQANLLKDTIISNAPEPDAAGTAAMAVKQEIESDNQQSYCSTQIDAL-KLTRENAGIAL 262
            .|||.:|         .:.||...:.|      .|...::...|..||:..|: ::.|.:.|:.:
Human   238 GSNGNRA---------TNGAPSLVSRG------MQGASANTLNSETSTKRAAVYRMNRNHRGLCV 287

  Fly   263 IINQQKFHRNVSRDNMKFLSPDPLRRRDGTDVDKERLIEVFSSMGYNVEAYDNVDHMGIIERI-- 325
            |:|...|              ..|:.|.||..|.|.|..||..:|:.|..::||..:. :|.:
Human   288 IVNNHSF--------------TSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVE-MEMVLQ 337

  Fly   326 RSACDRSLVRDSLVVF-ILSHGFEEAVYASNSIAMKITDIED----LLCSYDTLYYKPKLLIIQA 385
            :..|:.:.......|| ||:||...|||:|:...:.|.:|..    |.|  ..|..||||..|||
Human   338 KQKCNPAHADGDCFVFCILTHGRFGAVYSSDEALIPIREIMSHFTALQC--PRLAEKPKLFFIQA 400

  Fly   386 CQEKLVHKKKPNELFRIDVTTVSPDQ-----------HIDMLRAMSTVNGYAALRHTQTGSWFIG 439
            ||.:.:   :|:  ..|:...::|:|           ..|.|..::||.||.:.||.:.|||:|.
Human   401 CQGEEI---QPS--VSIEADALNPEQAPTSLQDSIPAEADFLLGLATVPGYVSFRHVEEGSWYIQ 460

  Fly   440 SLCDAIDRR-SASEHIADILTIVTNEVSK---KRGSNDESMVPNVKSTFRQHVYFP 491
            |||:.:.:. ...|.|..|||.|.::||:   |:|:  :..:|....|.|:.:.||
Human   461 SLCNHLKKLVPRHEDILSILTAVNDDVSRRVDKQGT--KKQMPQPAFTLRKKLVFP 514

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dredd	NP_477249.3	CASc	252..492	CDD:444667	78/262 (30%)
CASP10	NP_116759.2	DD	18..99	CDD:472698	23/90 (26%)
		DED_Caspase_10_r2	112..190	CDD:260074	17/107 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	231..269		10/52 (19%)
		CASc	276..514	CDD:214521	76/261 (29%)