Protein Alignment Dredd and CASP4

DIOPT Version :10

• Sequence 1: NP_477249.3
• Gene: Dredd / 31011
• FlyBaseID: FBgn0020381
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: NP_001216.1
• Gene: CASP4 / 837
• HGNCID: 1505
• Length: 377
• Species: Homo sapiens
• Alignment Length: 369
• Identity: 75/369 - (20%)
• Similarity: 136/369 - (36%)
• Gaps: 74/369 - (20%)

  Fly   170 LLDWLTRRSIKLGDINAAGSDVQLLVGHLKSNGLQAQANLLKD--TIISNAPEPDAAGTAAMAVK 232
            :|:|......|..|.... ..|:::...::.....|...||:.  .|...:|...|.........
Human    34 VLNWKEEEKKKYYDAKTE-DKVRVMADSMQEKQRMAGQMLLQTFFNIDQISPNKKAHPNMEAGPP 97

  Fly   233 QEIESDNQQSYCSTQIDALKLTRENA-------------GIALIINQQKFHRNVSRDNMKFLSPD 284
            :..||.:....|..: :.|:|.:|.|             .:||||...:|              |
Human    98 ESGESTDALKLCPHE-EFLRLCKERAEEIYPIKERNNRTRLALIICNTEF--------------D 147

  Fly   285 PLRRRDGTDVDKERLIEVFSSMGYNVEAYDNVDHMGIIERIRSACDRSLVR--DSLVVFILSHGF 347
            .|..|:|.|.|...:.|:...:.|:|:..:|:....:...:|:...|...:  ||..:.::|||.
Human   148 HLPPRNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRPEHKSSDSTFLVLMSHGI 212

  Fly   348 EEAVYASNSIAMKITDIEDLLCSYDTLYY------------KPKLLIIQAC----QEKLVHKKKP 396
            .|.:..:.....|    .|:|. |||::.            |||::|:|||    :.:|..:..|
Human   213 LEGICGTVHDEKK----PDVLL-YDTIFQIFNNRNCLSLKDKPKVIIVQACRGANRGELWVRDSP 272

  Fly   397 NELFRIDVTTVSPDQHI------------DMLRAMSTVNGYAALRHTQTGSWFIGSLCDAIDRRS 449
            ..|   :|.:....:::            |.:...|:.....:.|.:..||.||..|.....:.|
Human   273 ASL---EVASSQSSENLEEDAVYKTHVEKDFIAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYS 334

  Fly   450 ASEHIADILTIVTNEVSKKRGSNDESMVPNVK--STFRQHVYFP 491
            ...|:.::...|.......|.   ::.:|.::  |..|....||
Human   335 WCCHLEEVFRKVQQSFETPRA---KAQMPTIERLSMTRYFYLFP 375

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dredd	NP_477249.3	CASc	252..492	CDD:444667	60/285 (21%)
CASP4	NP_001216.1	Required for LPS-binding. /evidence=ECO:0000250|UniProtKB:P70343	1..59		5/25 (20%)
		CARD_CASP1-like	5..81	CDD:260036	9/47 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	84..104		4/19 (21%)
		CASc	126..375	CDD:214521	55/273 (20%)