DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dredd and Casp9

DIOPT Version :9

Sequence 1:	NP_477249.3	Gene:	Dredd / 31011	FlyBaseID:	FBgn0020381	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_113820.1	Gene:	Casp9 / 58918	RGDID:	61867	Length:	454	Species:	Rattus norvegicus

Alignment Length:	323	Identity:	78/323 - (24%)
Similarity:	131/323 - (40%)	Gaps:	66/323 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   209 LLKDTIISNAPEPDAAGTAA---MAVKQEIESDNQQSYCSTQIDALKLTRENAGIALIINQQKFH 270
            |..:.:....|.|...|:..   :....:||.....:|        .|..:..|..||||
  Rat   154 LRPEVLTPETPRPVDIGSGRAHDVCTPGKIERHADMAY--------TLDSDPCGHCLIIN----- 205

  Fly   271 RNVSRDNMKFLSPDPLRRRDGTDVDKERLIEVFSSMGYNVEAYDNVDHMGIIERIRSACDRS-LV 334
                  |:.|.....|..|.|:.||.|:|...|..:.:.||..:::....::..:.....|. ..
  Rat   206 ------NVNFCPSSGLSTRIGSHVDCEKLQHRFCWLRFMVEVKNDLTAKKMVTALMEMAHRDHRA 264

  Fly   335 RDSLVVFILSHG-------FEEAVYASNSIAMKITDIEDLL----CSYDTLYYKPKLLIIQAC-- 386
            .|..||.|||||       |..|||.::..::.|..|.::.    |  .:|..||||..||||
  Rat   265 LDCFVVVILSHGCQASHLQFPGAVYGTDGCSVSIERIVNIFNGTGC--PSLGGKPKLFFIQACGG 327

  Fly   387 --------------QEK----------LVHKKKPNELFRIDVTTVSPDQHIDMLRAMSTVNGYAA 427
                          |:|          :.:::.|..|.::|..:..|... |:|.:.||..|:.:
  Rat   328 EQKDHGFEVAFTSSQDKAFDSDSEPDAVPYQEGPRTLDQLDAVSSLPTPS-DILVSYSTFPGFVS 391

  Fly   428 LRHTQTGSWFIGSLCDAIDRRSASEHIADILTIVTNEVSKKRGSNDESMVPNVKSTFRQHVYF 490
            .|..::|||:|.:|...:::.:.||.:..:|..|.|.||:|   .....:|...:..|:.::|
  Rat   392 WRDKKSGSWYIETLDGVLEQWARSEDLQSLLLRVANAVSEK---GVYKQIPGCFNFLRKKLFF 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dredd	NP_477249.3	CASc	252..492	CDD:294037	71/277 (26%)
Casp9	NP_113820.1	CARD_CASP9	19..90	CDD:176740
Casp9	NP_113820.1	CASc	190..452	CDD:237997	72/287 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10454
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010