Protein Alignment Dredd and casp8

DIOPT Version :10

• Sequence 1: NP_477249.3
• Gene: Dredd / 31011
• FlyBaseID: FBgn0020381
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: NP_571585.2
• Gene: casp8 / 58022
• ZFINID: ZDB-GENE-000713-1
• Length: 476
• Species: Danio rerio
• Alignment Length: 465
• Identity: 115/465 - (24%)
• Similarity: 181/465 - (38%)
• Gaps: 107/465 - (23%)

  Fly    83 EALCIIGARKVLRRLGFCWQELRMHYL---PHIAGITLHVHPLLKSLYRMCEELSLVQSGRLLLD 144
            |.|..||...:|..|....:|:..:.|   ....|::.:...|||....|.||  ..::.:.|||
Zfish    61 ELLITIGRIDLLEILKKSKEEVERNLLRCDNSRKGVSAYRKMLLKISEDMTEE--NFRAAKFLLD 123

  Fly   145 V-REKVESQQAGDPLRFYDPAYLEIFLLDWLTRRSIKLGDIN---------AAGSDVQLLVGHLK 199
            : |.|:     |....|.| |.:|:       .:..:||..|         .....:.:::...:
Zfish   124 LPRAKL-----GRSTSFLD-ALIEM-------EKQQRLGPDNLDELYRILEKCDKQLAVMIERFR 175

  Fly   200 SNGLQAQA-------------NLLKDTIISNAPEPDAAGTAAMAVKQEIESDNQQSYCSTQIDAL 251
            :...:.|.             |.:.:|:........:|||.....:..:   |...|       .
Zfish   176 NQSHRDQEQGGRLPLEEVFLNNPVSETMERERRRNSSAGTITTDAETPL---NPNEY-------Y 230

  Fly   252 KLTRENAGIALIINQQKFHRNVSRDNMKFLSPDPLRRRDGTDVDKERLIEVFSSMGYNVEAYDNV 316
            .||:...|..||||           |..||....|.:|.|||:||:||.::||.|.:.:|..:::
Zfish   231 ILTQRPLGYCLIIN-----------NYNFLKSTNLLKRTGTDMDKDRLAKLFSRMHFQIEVRNDL 284

  Fly   317 DHMGIIERIRSACDRS-LVRDSLVVFILSHGFEEAVYASNSIAMKITDIEDLLCSYDTLYYKPKL 380
            :...|.:.|:...:|: ....:.|..|||||.:..|..::...::|.::........||..||||
Zfish   285 EAWAIKDEIKQFANRNHASMGAFVCCILSHGEKGTVLGTDGKPVEIREVTLPFAGCRTLASKPKL 349

  Fly   381 LIIQACQ---------------------EK-------LVHKKKPNELFRIDVTTVSPDQHIDMLR 417
            ..|||||                     ||       :|.:|.|.|              .|.|.
Zfish   350 FFIQACQGDENQAGVWTSDGREDAPEEDEKYEEDAGIIVLRKIPIE--------------ADFLI 400

  Fly   418 AMSTVNGYAALRHTQTGSWFIGSLCDAIDRR-SASEHIADILTIVTNEVSKKRGSNDESMVPNVK 481
            .|:||..|.:.|||:.||.||..||..::.. ...|.:..|||.|..||||:.....:.| |..:
Zfish   401 GMATVEHYLSYRHTKEGSIFIQELCKKMEELCPKKEDMLSILTKVNFEVSKRILKGYKQM-PEPR 464

  Fly   482 STFRQHVYFP 491
            .|..:.:..|
Zfish   465 YTLTKKLVLP 474

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dredd	NP_477249.3	CASc	252..492	CDD:444667	79/270 (29%)
casp8	NP_571585.2	DED_Caspase_8_10_r1	2..76	CDD:260059	5/14 (36%)
		DED_Caspase_8_10_r2	96..176	CDD:260042	19/94 (20%)
		CASc	229..474	CDD:237997	79/277 (29%)