Protein Alignment Dredd and CASP14

DIOPT Version :10

• Sequence 1: NP_477249.3
• Gene: Dredd / 31011
• FlyBaseID: FBgn0020381
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: NP_036246.1
• Gene: CASP14 / 23581
• HGNCID: 1502
• Length: 242
• Species: Homo sapiens
• Alignment Length: 241
• Identity: 64/241 - (26%)
• Similarity: 105/241 - (43%)
• Gaps: 65/241 - (26%)

  Fly   287 RRRDGTDVDKERLIEVFSSMGY--------NVEAYDNVDHMGIIERIRSACDRSLVRDSLV---- 339
            :.|:|::.|.:.|..:|..:.:        ..|.:...     :|:.:.|.|.   |:..|
Human    27 KAREGSEEDLDALEHMFRQLRFESTMKRDPTAEQFQEE-----LEKFQQAIDS---REDPVSCAF 83

  Fly   340 VFILSHGFEEAVYASNSIAMKITDIEDLL----CSYDTLYYKPKLLIIQACQEKLVHKKKPNELF 400
            |.:::||.|..:...:...:|:.::.:.|    |  ..|..|||:.|||||:.:   ::.|.|
Human    84 VVLMAHGREGFLKGEDGEMVKLENLFEALNNKNC--QALRAKPKVYIIQACRGE---QRDPGE-- 141

  Fly   401 RIDVTTVSPDQ--------------HIDMLRAMSTVNGYAALRHTQTGSWFIGSLCDAIDRRSAS 451
                 ||..|:              :.|.|...|||.||.|.||.|.||.||.:|.|...:|..
Human   142 -----TVGGDEIVMVIKDSPQTIPTYTDALHVYSTVEGYIAYRHDQKGSCFIQTLVDVFTKRKG- 200

  Fly   452 EHIADILTIVTNEVS--------KKRGSNDESMVPNVKSTFRQHVY 489
             ||.::||.||..::        |.|.:|     |.::||.|:.:|
Human   201 -HILELLTEVTRRMAEAELVQEGKARKTN-----PEIQSTLRKRLY 240

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dredd	NP_477249.3	CASc	252..492	CDD:444667	64/241 (27%)
CASP14	NP_036246.1	CASc	18..242	CDD:237997	64/241 (27%)