DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dredd and Cflar

DIOPT Version :9

Sequence 1:NP_477249.3 Gene:Dredd / 31011 FlyBaseID:FBgn0020381 Length:494 Species:Drosophila melanogaster
Sequence 2:NP_001276633.1 Gene:Cflar / 12633 MGIID:1336166 Length:481 Species:Mus musculus


Alignment Length:563 Identity:99/563 - (17%)
Similarity:178/563 - (31%) Gaps:239/563 - (42%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 LIH-----LDTIDQNDLIYVERDM--------------NFAQKVGLCFLLYGDDHSDATYILQKL 52
            :||     ||..::..::::.||:              :.:::..|.|         ||  |.:|
Mouse    10 VIHQVEECLDEDEKEMMLFLCRDVTENLAAPNVRDLLDSLSERGQLSF---------AT--LAEL 63

  Fly    53 LAMTRSDFPQSDLLIKFAKSRPETWRRHLVEALCIIGARKVLRRLGFCWQELRMHYLPHIAGITL 117
            |...|    :.|||.:..|:...|...|             |||                     
Mouse    64 LYRVR----RFDLLKRILKTDKATVEDH-------------LRR--------------------- 90

  Fly   118 HVHPLLKSLYRMCEELSLVQSGRLLLDVREKVESQQAGDPL---RFY--------DPAYLEIFLL 171
              :|.|.|.||:           ||:::.|.::.......:   |.|        |.::|::.  
Mouse    91 --NPHLVSDYRV-----------LLMEIGESLDQNDVSSLVFLTRDYTGRGKIAKDKSFLDLV-- 140

  Fly   172 DWLTRRSIKLGDINAAGSD-VQLLVGHLK----------------------SNGLQAQANLLKDT 213
                   |:|..:|...|| :.||...||                      ||....||:|.|.:
Mouse   141 -------IELEKLNLIASDQLNLLEKCLKNIHRIDLNTKIQKYTQSSQGARSNMNTLQASLPKLS 198

  Fly   214 IISNAPEPDAAGTAAMAVKQEIESDNQQSYCSTQI-------------DALKLTRENAGIALIIN 265
            |..|:...:........|:..   |:|::...|.|             :..::..:..||.||| 
Mouse   199 IKYNSRLQNGRSKEPRFVEYR---DSQRTLVKTSIQESGAFLPPHIREETYRMQSKPLGICLII- 259

  Fly   266 QQKFHRNVSRDNMKFLSPDPLRRRDGTDVDKERLIEVFSSMGYNVEAY---DNVDHMGIIERIRS 327
                                    |....|.:.|.|.|:|:||:::.:   .:.|...|:.|..|
Mouse   260 ------------------------DCIGNDTKYLQETFTSLGYHIQLFLFPKSHDITQIVRRYAS 300

  Fly   328 ACDRSLVRDSLVVFILSHGFEEAVYASNSI--AMKITDIEDLLCSYDT---LYYKPKLLIIQ--- 384
            ..... ..||....::|.|..:::...:.:  ...:..::::... ||   |..||||..||   
Mouse   301 MAQHQ-DYDSFACVLVSLGGSQSMMGRDQVHSGFSLDHVKNMFTG-DTCPSLRGKPKLFFIQNYE 363

  Fly   385 ------------------------------------------ACQEKLVHKKKPNELFRIDVTTV 407
                                                      .|...:.|.:||:....:.:..:
Mouse   364 SLGSQLEDSSLEVDGPSIKNVDSKPLQPRHCTTHPEADIFWSLCTADVSHLEKPSSSSSVYLQKL 428

  Fly   408 SP-----------DQHIDML-------RAMSTVNGYA-ALRHT 431
            |.           |.|::::       ..:|:...|: :|:||
Mouse   429 SQQLKQGRRRPLVDLHVELMDKVYAWNSGVSSKEKYSLSLQHT 471

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DreddNP_477249.3 CASc 252..492 CDD:294037 42/252 (17%)
CflarNP_001276633.1 Interaction with CASP8 propeptide. /evidence=ECO:0000250|UniProtKB:O15519 6..307 74/396 (19%)
Interaction with FADD. /evidence=ECO:0000250|UniProtKB:O15519 6..229 55/292 (19%)
Interaction with CASP8. /evidence=ECO:0000250|UniProtKB:O15519 6..200 50/260 (19%)
DED_c-FLIP_r1 6..85 CDD:260044 19/89 (21%)
DED_c-FLIP_r2 96..176 CDD:260046 19/99 (19%)
Interaction with TRAF1 and TRAF2. /evidence=ECO:0000250|UniProtKB:O15519 197..481 49/305 (16%)
Interaction with CASP3. /evidence=ECO:0000250|UniProtKB:O15519 197..436 42/268 (16%)
Interaction with CASP8 subunits p18 and p10. /evidence=ECO:0000250|UniProtKB:O15519 219..481 46/283 (16%)
CASc 246..480 CDD:214521 42/253 (17%)
Caspase 265..360 22/96 (23%)
Interaction with CASP8. /evidence=ECO:0000250|UniProtKB:O15519 372..481 12/100 (12%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3573
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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