Protein Alignment Dredd and Cflar

DIOPT Version :10

• Sequence 1: NP_477249.3
• Gene: Dredd / 31011
• FlyBaseID: FBgn0020381
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: NP_997536.1
• Gene: Cflar / 12633
• MGIID: 1336166
• Length: 481
• Species: Mus musculus
• Alignment Length: 563
• Identity: 99/563 - (17%)
• Similarity: 178/563 - (31%)
• Gaps: 239/563 - (42%)

  Fly     7 LIH-----LDTIDQNDLIYVERDM--------------NFAQKVGLCFLLYGDDHSDATYILQKL 52
            :||     ||..::..::::.||:              :.:::..|.|         ||  |.:|
Mouse    10 VIHQVEECLDEDEKEMMLFLCRDVTENLAAPNVRDLLDSLSERGQLSF---------AT--LAEL 63

  Fly    53 LAMTRSDFPQSDLLIKFAKSRPETWRRHLVEALCIIGARKVLRRLGFCWQELRMHYLPHIAGITL 117
            |...|    :.|||.:..|:...|...|             |||
Mouse    64 LYRVR----RFDLLKRILKTDKATVEDH-------------LRR--------------------- 90

  Fly   118 HVHPLLKSLYRMCEELSLVQSGRLLLDVREKVESQQAGDPL---RFY--------DPAYLEIFLL 171
              :|.|.|.||:           ||:::.|.::.......:   |.|        |.::|::.
Mouse    91 --NPHLVSDYRV-----------LLMEIGESLDQNDVSSLVFLTRDYTGRGKIAKDKSFLDLV-- 140

  Fly   172 DWLTRRSIKLGDINAAGSD-VQLLVGHLK----------------------SNGLQAQANLLKDT 213
                   |:|..:|...|| :.||...||                      ||....||:|.|.:
Mouse   141 -------IELEKLNLIASDQLNLLEKCLKNIHRIDLNTKIQKYTQSSQGARSNMNTLQASLPKLS 198

  Fly   214 IISNAPEPDAAGTAAMAVKQEIESDNQQSYCSTQI-------------DALKLTRENAGIALIIN 265
            |..|:...:........|:..   |:|::...|.|             :..::..:..||.|||
Mouse   199 IKYNSRLQNGRSKEPRFVEYR---DSQRTLVKTSIQESGAFLPPHIREETYRMQSKPLGICLII- 259

  Fly   266 QQKFHRNVSRDNMKFLSPDPLRRRDGTDVDKERLIEVFSSMGYNVEAY---DNVDHMGIIERIRS 327
                                    |....|.:.|.|.|:|:||:::.:   .:.|...|:.|..|
Mouse   260 ------------------------DCIGNDTKYLQETFTSLGYHIQLFLFPKSHDITQIVRRYAS 300

  Fly   328 ACDRSLVRDSLVVFILSHGFEEAVYASNSI--AMKITDIEDLLCSYDT---LYYKPKLLIIQ--- 384
            ..... ..||....::|.|..:::...:.:  ...:..::::... ||   |..||||..||
Mouse   301 MAQHQ-DYDSFACVLVSLGGSQSMMGRDQVHSGFSLDHVKNMFTG-DTCPSLRGKPKLFFIQNYE 363

  Fly   385 ------------------------------------------ACQEKLVHKKKPNELFRIDVTTV 407
                                                      .|...:.|.:||:....:.:..:
Mouse   364 SLGSQLEDSSLEVDGPSIKNVDSKPLQPRHCTTHPEADIFWSLCTADVSHLEKPSSSSSVYLQKL 428

  Fly   408 SP-----------DQHIDML-------RAMSTVNGYA-ALRHT 431
            |.           |.|::::       ..:|:...|: :|:||
Mouse   429 SQQLKQGRRRPLVDLHVELMDKVYAWNSGVSSKEKYSLSLQHT 471

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dredd	NP_477249.3	CASc	252..492	CDD:444667	42/252 (17%)
Cflar	NP_997536.1	Interaction with CASP8 propeptide. /evidence=ECO:0000250|UniProtKB:O15519	6..307		74/396 (19%)
		Interaction with FADD. /evidence=ECO:0000250|UniProtKB:O15519	6..229		55/292 (19%)
		Interaction with CASP8. /evidence=ECO:0000250|UniProtKB:O15519	6..200		50/260 (19%)
		DED_c-FLIP_r1	6..85	CDD:260044	19/89 (21%)
		DED_c-FLIP_r2	96..176	CDD:260046	19/99 (19%)
		Interaction with TRAF1 and TRAF2. /evidence=ECO:0000250|UniProtKB:O15519	197..481		49/305 (16%)
		Interaction with CASP3. /evidence=ECO:0000250|UniProtKB:O15519	197..436		42/268 (16%)
		Interaction with CASP8 subunits p18 and p10. /evidence=ECO:0000250|UniProtKB:O15519	219..481		46/283 (16%)
		CASc	246..480	CDD:214521	42/253 (17%)
		Caspase	265..360		22/96 (23%)
		Interaction with CASP8. /evidence=ECO:0000250|UniProtKB:O15519	372..481		12/100 (12%)