Protein Alignment Dredd and Casp8

DIOPT Version :9

• Sequence 1: NP_477249.3
• Gene: Dredd / 31011
• FlyBaseID: FBgn0020381
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: NP_001264855.1
• Gene: Casp8 / 12370
• MGIID: 1261423
• Length: 500
• Species: Mus musculus
• Alignment Length: 422
• Identity: 110/422 - (26%)
• Similarity: 183/422 - (43%)
• Gaps: 87/422 - (20%)

  Fly   119 VHPLLKSLYRMCEELSLVQ--SGRLLLDVREKVESQQAGDPLRFYDPAYLEIFL----------- 170
            :.|....|:::.||:|.::  |.:.||:  .::...:..|     |.:.||||:
Mouse   118 ISPYRVMLFKLSEEVSELELRSFKFLLN--NEIPKCKLED-----DLSLLEIFVEMEKRTMLAEN 175

  Fly   171 -LDWLTRRSI----------KLGDINAAGSDVQLLVGHLKSNGLQAQANLLKDTIISNAPEPDAA 224
             |:  |.:||          |:.|...:.::.::        .|:.:..|          .|...
Mouse   176 NLE--TLKSICDQVNKSLLGKIEDYERSSTERRM--------SLEGREEL----------PPSVL 220

  Fly   225 GTAAMAVKQEIESDNQQ-SYCSTQIDALKLTRENAGIALIINQQKFHRNVSRDNMKFLSPDPLRR 288
            ...::.:.:..:|..:| |...|.....::..:..|..||||...|.:  :|:::..|.  .::.
Mouse   221 DEMSLKMAELCDSPREQDSESRTSDKVYQMKNKPRGYCLIINNHDFSK--AREDITQLR--KMKD 281

  Fly   289 RDGTDVDKERLIEVFSSMGYNVEAYD----NVDHMGIIERIRSACDRSLVRDSLVVFILSHGFEE 349
            |.|||.|||.|.:.|..:.:.:.:||    |..| .|:|..:||..::  :|..:..|||||.:.
Mouse   282 RKGTDCDKEALSKTFKELHFEIVSYDDCTANEIH-EILEGYQSADHKN--KDCFICCILSHGDKG 343

  Fly   350 AVYASNSIAMKITDIEDLLCSYDT------LYYKPKLLIIQACQEKLVHKKKPNEL------FRI 402
            .||.::.....|.|    |.||.|      |..|||:..|||||.....|..|:|.      ..:
Mouse   344 VVYGTDGKEASIYD----LTSYFTGSKCPSLSGKPKIFFIQACQGSNFQKGVPDEAGFEQQNHTL 404

  Fly   403 DVTTVS-----PDQHIDMLRAMSTVNGYAALRHTQTGSWFIGSLCDAI-DRRSASEHIADILTIV 461
            :|.:.|     ||: .|.|..|:||....:.|....|:|:|.|||.:: :|....:.|..|||.|
Mouse   405 EVDSSSHKNYIPDE-ADFLLGMATVKNCVSYRDPVNGTWYIQSLCQSLRERCPQGDDILSILTGV 468

  Fly   462 TNEVSKKRG-SNDESMVPNVKSTFRQHVYFPP 492
            ..:||.|.. .|....:|....|.|:.::|||
Mouse   469 NYDVSNKDDRRNKGKQMPQPTFTLRKKLFFPP 500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dredd	NP_477249.3	CASc	252..492	CDD:294037	81/262 (31%)
Casp8	NP_001264855.1	DED_Caspase_8_r1	23..104	CDD:260041
		DD	118..199	CDD:387368	20/89 (22%)
		CASc	247..499	CDD:237997	80/263 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3573
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	4	3.770