Protein Alignment Dredd and Casp2

DIOPT Version :10

• Sequence 1: NP_477249.3
• Gene: Dredd / 31011
• FlyBaseID: FBgn0020381
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: NP_031636.1
• Gene: Casp2 / 12366
• MGIID: 97295
• Length: 452
• Species: Mus musculus
• Alignment Length: 541
• Identity: 119/541 - (21%)
• Similarity: 192/541 - (35%)
• Gaps: 182/541 - (33%)

  Fly     9 HLDTIDQNDLIYVERDMNFAQKVGLCFLLYGDDH----SDATYILQKLLAMTRSDFPQS-DLLIK 68
            |.:|:.:|.::       .|:::.|..||   :|    ...|..:::|:......|.|: :||..
Mouse    36 HQETLKKNRVV-------LAKQLLLSELL---EHLLEKDIITLEMRELIQAKGGSFSQNVELLNL 90

  Fly    69 FAKSRPETWRRHLVEALCIIGARKVLRRLGFCWQELRMHYLPHIAGITL----HVHPLLKSLY-- 127
            ..|..|:.:     :|.|     :.||       |.|..:|..:...||    ||.|.|...|
Mouse    91 LPKRGPQAF-----DAFC-----EALR-------ETRQGHLEDLLLTTLSDIQHVLPPLSCDYDT 138

  Fly   128 ----RMCEELSLVQSGRLLLDVREKVESQQAGDPLRFYDPAYLEIFLLDWLTRRSIKLGDINAAG 188
                .:||.....:..||..|..|.......|.|.....|...|.:
Mouse   139 SLPFSVCESCPPHKQLRLSTDATEHSLDNGDGPPCLLVKPCTPEFY------------------- 184

  Fly   189 SDVQLLVGHLKSNGLQAQANLLKDTIISNAPEPDAAGTAAMAVKQEIESDNQQSYCSTQIDALKL 253
                           ||...|                                        |.:|
Mouse   185 ---------------QAHYQL----------------------------------------AYRL 194

  Fly   254 TRENAGIALIINQQKFHRNVSRDNMKFLSPDPLRRRDGTDVDKERLIEVFSSMGYNVEAYDNVDH 318
            ..:..|:||:::           |:.|.....|..|.|.|||...|:.:|..:||||....:...
Mouse   195 QSQPRGLALVLS-----------NVHFTGEKDLEFRSGGDVDHTTLVTLFKLLGYNVHVLHDQTA 248

  Fly   319 MGIIERIRSACD--RSLVRDSLVVFILSHGFEEAVYASNSIAMKITDIEDLLCSYD-----TLYY 376
            ..:.|::::...  ...|.||.||.:||||.|..:|..:.   |:..::::...:|     :|..
Mouse   249 QEMQEKLQNFAQLPAHRVTDSCVVALLSHGVEGGIYGVDG---KLLQLQEVFRLFDNANCPSLQN 310

  Fly   377 KPKLLIIQAC-----------QEKLVHKKKP---------NELFRIDVTTVSPDQHIDMLRAMST 421
            |||:..||||           |:...|.:.|         .||.::.:.|.|     ||:...:.
Mouse   311 KPKMFFIQACRGDETDRGVDQQDGKNHTQSPGCEESDAGKEELMKMRLPTRS-----DMICGYAC 370

  Fly   422 VNGYAALRHTQTGSWFIGSLCDAIDRRSASEHIADILTIVTNEVSKKRGSNDESMVPNVK----- 481
            :.|.||:|:|:.|||:|.:|......|:...|:||:| :..|.:.|:|    |...|..:
Mouse   371 LKGNAAMRNTKRGSWYIEALTQVFSERACDMHVADML-VKVNALIKER----EGYAPGTEFHRCK 430

  Fly   482 ------STFRQHVY----FPP 492
                  ||..|.:|    :||
Mouse   431 EMSEYCSTLCQQLYLFPGYPP 451

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dredd	NP_477249.3	CASc	252..492	CDD:444667	73/281 (26%)
Casp2	NP_031636.1	CARD_CASP2	32..118	CDD:260040	23/108 (21%)
		CASc	192..447	CDD:214521	73/278 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	327..349		3/21 (14%)