Protein Alignment Dredd and Casp4

DIOPT Version :9

• Sequence 1: NP_477249.3
• Gene: Dredd / 31011
• FlyBaseID: FBgn0020381
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: NP_031635.2
• Gene: Casp4 / 12363
• MGIID: 107700
• Length: 373
• Species: Mus musculus
• Alignment Length: 445
• Identity: 97/445 - (21%)
• Similarity: 161/445 - (36%)
• Gaps: 130/445 - (29%)

  Fly    92 KVLRRLGFCWQELRMHYLPHIAGITLHVHPLLKSLYRMCEELSLVQSGRLLLDVREKVESQQAGD 156
            |||.:||   :|:...||.                       .||||..|.|    |.|.:|..:
Mouse    12 KVLEQLG---KEVLTEYLE-----------------------KLVQSNVLKL----KEEDKQKFN 46

  Fly   157 PLRFYDPAYLEIFLLDWLTRRSIKLGDINAAGSDVQLLVGHLKSNGLQAQANLLKDTIISNAPEP 221
            .....|..::   .:|.:.::..|:|:                         :|..|..|..| .
Mouse    47 NAERSDKRWV---FVDAMKKKHSKVGE-------------------------MLLQTFFSVDP-G 82

  Fly   222 DAAGTAAMAVKQEIESDNQQSYCSTQIDALKLTRE-------------NAGIALIINQQKFHRNV 273
            ...|.|.:.:::..||.|....||.: :..:|.||             ....||||...:|
Mouse    83 SHHGEANLEMEEPEESLNTLKLCSPE-EFTRLCREKTQEIYPIKEANGRTRKALIICNTEF---- 142

  Fly   274 SRDNMKFLSPDPLRRRDGTDVDKERLIEVFSSMGYNVEAYDNVDHMGIIERIR--SACDRSLVRD 336
                 |.||     .|.|.:.|...:..:...:||:|...:.:...|:...::  :|.......|
Mouse   143 -----KHLS-----LRYGANFDIIGMKGLLEDLGYDVVVKEELTAEGMESEMKDFAALSEHQTSD 197

  Fly   337 SLVVFILSHGFEEAVYASNSIAMKITDIEDLLCSYDTLYY------------KPKLLIIQACQ-- 387
            |..:.::|||....:..:    |......|:| .|||:|.            |||::|:|||:
Mouse   198 STFLVLMSHGTLHGICGT----MHSEKTPDVL-QYDTIYQIFNNCHCPGLRDKPKVIIVQACRGG 257

  Fly   388 ---EKLVHKKKPNELFR---------IDVTTVSPDQHI--DMLRAMSTVNGYAALRHTQTGSWFI 438
               |..:.:....:|.|         .|...:|   |:  |.:...||...:.:.|....||:||
Mouse   258 NSGEMWIRESSKPQLCRGVDLPRNMEADAVKLS---HVEKDFIAFYSTTPHHLSYRDKTGGSYFI 319

  Fly   439 GSLCDAIDRRSASEHIADILTIVTNEVSKKRGSNDESMVPNV-KSTFRQHVY-FP 491
            ..|.....:.:.|.|:.||...|.....|   ::..|.:|.: ::|..::.| ||
Mouse   320 TRLISCFRKHACSCHLFDIFLKVQQSFEK---ASIHSQMPTIDRATLTRYFYLFP 371

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dredd	NP_477249.3	CASc	252..492	CDD:294037	65/285 (23%)
Casp4	NP_031635.2	Required for LPS-binding. /evidence=ECO:0000269|PubMed:25119034	1..59		18/79 (23%)
		CARD_CASP1-like	5..85	CDD:260036	25/131 (19%)
		CASc	122..371	CDD:214521	60/273 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3573
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10454
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910