DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dredd and si:ch211-195h23.3

DIOPT Version :9

Sequence 1:	NP_477249.3	Gene:	Dredd / 31011	FlyBaseID:	FBgn0020381	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	XP_021334238.1	Gene:	si:ch211-195h23.3 / 100170660	ZFINID:	ZDB-GENE-070912-174	Length:	1001	Species:	Danio rerio

Alignment Length:	351	Identity:	68/351 - (19%)
Similarity:	123/351 - (35%)	Gaps:	117/351 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 FYDPAYLEIFLLDWLTRRSIKLGDINAAGSDVQLLVGHLKSNGLQAQANLLKDTIISNAPEP--- 221
            |..|||.:..      ||   |.|::....|.:.|  |        ||:.....|..|| :|
Zfish   264 FPRPAYRKYM------RR---LEDLSDETLDSRFL--H--------QAHTFCSYIYDNA-QPKTV 308

  Fly   222 -------DAAGTAAMAVKQEIESDNQQSYCSTQIDALKLTRENAGIAL--IIN-------QQKFH 270
                   .|.|..|....:.|.|.|            .:..|||.::|  |.|       :|.:.
Zfish   309 RGHTITGTALGNLAEIYVEAISSGN------------VICLENAVVSLAKIQNVRAVDQARQIYK 361

  Fly   271 RNVSRDNMKFLSPDPLRRRDGTDVDKERLIEVFSSMGYNVEAYDNVDHMGIIERIRSACDRSLVR 335
            ..:.|.....|.||.|.|..  .:.:|:.|:||.:|.::.:  |.:....::|:|.
Zfish   362 EEMLRMAQPPLDPDQLSRIH--TLAEEKAIKVFINMSFSDK--DQIYQKELMEKIH--------- 413

  Fly   336 DSLVVFILSHGFEEAVYASNSIAMKITDIEDLLCSYDTLYYKPKLLIIQACQEKLVHKKKPNELF 400
                     |.::.....::.                        ..:..|::.|.:...|.||.
Zfish   414 ---------HEYQHMCLQNHQ------------------------AFLMQCRKVLEYSFYPLELK 445

  Fly   401 RIDVTTVSPD---QHIDMLRAMSTVNGYAA-----LRHTQT------GSWFIGS-LCDAIDRRSA 450
            ..|.:.:.|.   |:..:|..:  ::.|.|     ::|.:.      |...:|: :..|.:..||
Zfish   446 ISDGSYLRPGGYRQYRALLNQL--ISDYRARTESQIKHEEALWMFLQGKEDVGNQILQADESLSA 508

  Fly   451 SEHIADILTIVTNEV--SKKRGSNDE 474
            :|...:: .|:.||:  ..:||..::
Zfish   509 AEQEKEV-QILKNEILQQHQRGLEEQ 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dredd	NP_477249.3	CASc	252..492	CDD:294037	45/249 (18%)
si:ch211-195h23.3	XP_021334238.1	P-loop_NTPase	51..307	CDD:328724	17/62 (27%)
		GBP_C	315..602	CDD:293879	51/280 (18%)
		coiled coil	573..584	CDD:293879
		coiled coil	593..602	CDD:293879
		FIIND	645..885	CDD:316110
		CARD_ASC_NALP1	910..991	CDD:260039
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3573
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900