DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mybbp1A and pol5

DIOPT Version :9

Sequence 1:	NP_476593.2	Gene:	Mybbp1A / 31010	FlyBaseID:	FBgn0001341	Length:	1133	Species:	Drosophila melanogaster
Sequence 2:	NP_595917.1	Gene:	pol5 / 2539834	PomBaseID:	SPBC14C8.14c	Length:	959	Species:	Schizosaccharomyces pombe

Alignment Length:	1038	Identity:	209/1038 - (20%)
Similarity:	393/1038 - (37%)	Gaps:	258/1038 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 KAVFVVFKKMQGSQLTKKMINSLITLLRDDTNAEQRTATTGYVLKRLIR--STGADDMKTVSLAA 136
            |....:|.|:..:....: ::|...|:...:|.|:    ..|.|.||.:  |:|.:..: :..|.
pombe     4 KTQLELFTKLTSNDKAIR-LSSAAQLIDSLSNEEE----LKYSLNRLTKGLSSGRESAR-IGFAV 62

  Fly   137 SYIHCILNAVPAIDAFEVLETLKRDLAVGSQQRGKEDSLAAVGQLVTAFCILQTPQFAKAEPKLV 201
            :... :|.....|.|..||:.|.:........:|:::.....|.|.....|:.:......|..:.
pombe    63 ALTE-LLTRTKDIRATHVLDLLVKHNTASGNLKGQDERDFYFGLLFGLQSIVYSGILTHKESTIE 126

  Fly   202 TAVFQ---ILAAQLKGRE-YLVSLCGDILAVSFKQLPAAIFEEYVW----PLLQ-PELNKPLSGL 257
            .  ||   .|..||.|:: :|..:|..::....:|:|...|....:    .||| |.::|...|:
pombe   127 D--FQRVVDLLLQLSGKKNWLQDVCFYVIYKLVEQIPEISFSSNAFLAVNKLLQTPAVSKSTEGV 189

  Fly   258 KVNTC-----------DVLLA-------VH----LTFSSVL--------GRENILASLWPKK--P 290
            .:..|           :|.:|       :|    :|.|.::        |.:|   |.|.:|  .
pombe   190 GLFLCLTRVPDNVKSEEVAMANWEPAHPLHKSNLVTLSKIMRQADASETGGQN---SAWKQKIPM 251

  Fly   291 VYTQLFDLY----FSG--------STIHSDGVYARLASFLVNGGKDMLAAWQQYIDSKQPLKLNA 343
            |:..:|:.|    :||        :.:..:|:::..:|.                         .
pombe   252 VWKYIFEEYQRKTYSGLAPFHDFWAVVVDEGIFSSTSSL-------------------------E 291

  Fly   344 AKACAIQVLSHVLLNFKPREEQLILDIFTPTCVQFLLHECSSVKWDKGEGKKPSLKKLKEICFKF 408
            .|....|:: .:.|::...:.  |.|||:...:..|::..|..........|....||:::. |.
pombe   292 RKFWGFQIM-ELALDYVSSDN--IGDIFSKNFLHCLINHLSDEDRYLYRAAKRVTSKLEKVS-KQ 352

  Fly   409 EGSLV------LCYEKQFQNDDNKLHLLLKLLEHTLQLDSVISLPRFCQKLINQL-----SVESL 462
            ..:||      |..|:...|.|...:  .||:||.|.|.....:.:..|.|::.:     .:.|.
pombe   353 NPTLVYPIAIHLLGERGSLNFDRVTN--TKLVEHILPLADEQGILQLFQLLLSYVKRCPEDIASD 415

  Fly   463 HKLYDYYNNKLYSLEDEDRVSRVHCLNQMQLILNHSKLSQTAKWRQKQLNYLLLAGLFHLDASKK 527
            .|..::              .|....:.|..||...:..:...|.::.|...:..|.|.:..|
pombe   416 TKAVEW--------------RRQWATDTMLSILRSKRSIKQEPWVRELLEIFIAYGYFEVPES-- 464

  Fly   528 PCEAAQASAFSRQCAARCEEIFLGSLLHKCS-GLPGLCQL-LQKTLSYLNKE-LGQPDAESKL-- 587
                              ||:     :.|.| |...:.:| |...||||:.. ..|...:.:|
pombe   465 ------------------EEV-----IPKFSEGTQNMFRLRLMSALSYLSSSAFQQSQTDHQLGD 506

  Fly   588 ---------------RSPR-------DES----LQKAWKQVEKLLERPSKESDVVGQ--SFEALI 624
                           :||:       |||    :||:...:.|:.::..|::..:.|  :|:.|.
pombe   507 KNWPYVALNYLLELEKSPKNNLLISMDESVIEIVQKSLSVLHKVTKKIDKKAQHLQQLNAFQLLY 571

  Fly   625 LFVSLALCTKIPPSITVLEDLIICRKNALQK--SKEQVNEELKWQDVLTDALLQLLLQTGHFWRE 687
            ..|.|.:......||.||||:..|......|  .:|..:.|....::||:.:|.||.:.....|:
pombe   572 SLVLLQVYAGDTDSIDVLEDIDNCYSKVFNKKSKRESTSNEPTAMEILTEVMLSLLSRPSLLLRK 636

  Fly   688 FVQLVATALIPHLEHGNLEQVLEVLNMNKNPLSKKSD----GEEESDDELDKEESLKDSSDDSED 748
            .|.::.|:....:...::..:.:||...::  .|.|:    |||..:|...:.|.   ..||.|:
pombe   637 LVDMLFTSFSEDMNRESIHLICDVLKAKES--VKDSEGMFAGEEVEEDAFGETEM---DEDDFEE 696

  Fly   749 EDEDEEEDEGEDDAESHL-AQIRESVRQAL---VNDGDA---DDDGASSVDWNDVDEEQGERLNA 806
            .|.||.|::.:.:..|:. |...|.:.:.|   :.|.||   |::.:.....||      |::.|
pombe   697 IDTDEIEEQSDWEMISNQDASDNEELERKLDKVLEDADAKVKDEESSEEELMND------EQMLA 755

  Fly   807 ALERSFQMFRPKSRKAQEKERPTKSERIDSTNLLHFRIRALDLLELFITKKPTQSV----ILDVL 867
            ..|:..::||.: :||..||: .|:.:.....::.|:::.:||::.:...:|...:    ::.:|
pombe   756 LDEKLAEVFRER-KKASNKEK-KKNAQETKQQIVQFKVKVIDLIDNYYKTQPNNGLGFEFLIPLL 818

  Fly   868 HCVFQVYSHCAADSKLQSLREASLKLLKKILARNIELKENQSTAPILEAIEQ----------LMS 922
            ..:.:. .|...:.|.|::....|..||       ..:|..|:..:|||:::          |.|
pombe   819 EMILKT-KHKVLEEKGQAVFRNRLSKLK-------WTEEKPSSKNVLEALKKVHVLCGKKASLGS 875

  Fly   923 SGEEHSEEDQENGKQPASRQAKRDIIIWRDRCFAYLVSQASADGEPKKSAVWPLLVEFLELWV 985
            :|...|:                            |:.:..||....|..|...|..|| ||:
pombe   876 TGSSISQ----------------------------LLLKLLADTPYLKEGVEVYLKSFL-LWI 909

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mybbp1A	NP_476593.2	DNA_pol_phi	115..854	CDD:309870	175/850 (21%)
pol5	NP_595917.1	DNA_pol_phi	40..800	CDD:282748	175/849 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1926
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR13213
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R341
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.030