DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mybbp1A and Mybbp1a

DIOPT Version :9

Sequence 1:	NP_476593.2	Gene:	Mybbp1A / 31010	FlyBaseID:	FBgn0001341	Length:	1133	Species:	Drosophila melanogaster
Sequence 2:	NP_058056.2	Gene:	Mybbp1a / 18432	MGIID:	106181	Length:	1344	Species:	Mus musculus

Alignment Length:	1267	Identity:	283/1267 - (22%)
Similarity:	484/1267 - (38%)	Gaps:	358/1267 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 LKKSKKEKPAETEEKENTASNANLKVSQINKAVFVVF-----KKMQGSQL--TKKMINSLITLLR 101
            :|...|.:||...|...:..::.|:.|:    .|:.|     |..|.::|  |:|::..|.|...
Mouse     4 MKSPTKAEPATPAEAAQSDRHSLLEHSR----EFLDFFWDIAKPDQETRLRATEKLLEYLRTRPN 64

  Fly   102 DDTNAEQRTATTGYVLKRLIRSTG-----ADDMKTVSLAASYIHCILNAVPAIDAFEVLETLKRD 161
            |   :|.:     |.|||||...|     |....:::||.     :|.:...|...::|:.::..
Mouse    65 D---SEMK-----YALKRLITGLGVGREAARPCYSLALAQ-----LLQSFEDIPLCDILDQIQEK 116

  Fly   162 LAVGSQQRG-KEDSLAAVGQLVTAFCILQTPQFAKAEPKLVTAV--FQILAA---QLKGREYLVS 220
            .::.:..:. ...||.|  .|.....:.|:.:..|.:..|:.:|  .:||:.   .|:|:.  :.
Mouse   117 YSLQAMNKAMMRPSLFA--NLFGVLALFQSGRLVKDKEALMKSVQLLKILSQHPNHLQGQP--IK 177

  Fly   221 LCGDILAVSFKQLPAAIFEEYVWPLLQPELNKPLSG-LKVNTCDVLLAVHLTFSSVLGRENILAS 284
            ...|||:    ::|.::|:|.        |.|.|.| :||                     ||.|
Mouse   178 ALVDILS----EVPESMFQEI--------LPKVLKGNMKV---------------------ILRS 209

  Fly   285 LWPKKPVYTQLFDLYFSGSTIHSDGVYARLASFLVNGGKDMLAAWQQYIDSKQPLKLNAAKACAI 349
                 |.|.:||       .:....|..:|.|.:  |..|:      :.:...|..:|..|..|.
Mouse   210 -----PKYLELF-------LLAKQRVPTKLESLM--GSVDL------FSEDNIPSLVNILKVAAN 254

  Fly   350 QV-LSHVLLNFKPREEQLILDIFTPTCVQFLLHECS-SVKWDK--GEG--KKPSLKKLKEICFKF 408
            .| ..|.|.|       :.||:     ::..|.|.. .:.|.|  .||  |.||... ..:||:.
Mouse   255 SVKKEHKLPN-------VALDL-----LRLALKESRFELFWKKVLEEGLLKNPSWTS-SYMCFRL 306

  Fly   409 EG-SLVLCYEKQFQNDDNKLHLLLK--LLEHTLQLDSVISLPRFCQKLINQLSVESLHKLYDYYN 470
            .| ||.|..|:|.|       |:::  |:.|..: :.|||.|:...|:|.::|.        |..
Mouse   307 LGASLPLLSEEQLQ-------LVMRGDLIRHFGE-NMVISKPQNLFKIIPEIST--------YVG 355

  Fly   471 NKLYSLEDEDR------VSRVHCLNQ----------MQLILNHSKLSQTAKW-----RQKQLNYL 514
            ..|...:|:.:      |:.....||          :...||...|.....|     .|..||.|
Mouse   356 TFLEGCQDDPKRQLTMMVAFTTITNQGLPVMPTFWRVTRFLNAEALQSYVAWLRDMFLQPDLNSL 420

  Fly   515 ---------------------------------LLAGLFHLDASKKPCEAAQASAF--------S 538
                                             |::.:.||...|......|.:.|        :
Mouse   421 VDFSTANQKRAQDASLNVPERAVFRLRKWIIHRLVSLVDHLHLEKDEAVVEQIARFCLFHAFFKT 485

  Fly   539 RQCAARCEE---------------IFLG---SLLHKCS------------GLPGLCQLLQKTLSY 573
            ::...:..|               :|:.   |||...|            |.|...:|:|.....
Mouse   486 KKATPQIPETKQHFSFPLDDRNRGVFVSAFFSLLQTLSVKFRQTPDLAENGKPWTYRLVQLADML 550

  Fly   574 LNKELGQPDAESKLRSPRDESLQKAWKQ-VEKLLERPSKESDVVGQSFEALILFVSLALCTKIPP 637
            ||.........|.....|     :||.| :..|.|..::.|:....:|:.|:|.|.|.:......
Mouse   551 LNHNRNVTSVTSLTTQQR-----QAWDQMMSTLKELEARSSETRAIAFQHLLLLVGLHIFKSPAE 610

  Fly   638 SITVLEDLIICRKNALQ------KSKEQVNEELKWQDVLTDALLQLLLQTGHFWREFVQLVATAL 696
            |..||.|:..|.|.:::      :|:.:.::|..|.:|:.:.||.||.|..:..|:.|:.|...:
Mouse   611 SCDVLGDIQTCIKKSMEQNPRRSRSRAKASQEPVWVEVMVEILLSLLAQPSNLMRQVVRSVFGHI 675

  Fly   697 IPHLEHGNLEQVLEVLNMNKNPLSKKSD-----------------GEEESDDELDKEESLKDSSD 744
            .|||....|:.:|.||    :|::.:.:                 ||:|..|..|.:.|  :|..
Mouse   676 CPHLTPRCLQLILAVL----SPVTNEDEDDNVVVTDDADEKQLQHGEDEDSDNEDNKNS--ESDM 734

  Fly   745 DSEDEDEDEEEDEGEDDAESHLAQIRESVRQALVNDGDADDDGASSVDWNDVDEEQGERLNAALE 809
            ||||.:|.||||..:|.......|:.|     ::..|:|    ...|| |:.:||.|:....||:
Mouse   735 DSEDGEESEEEDRDKDVDPGFRQQLME-----VLKAGNA----LGGVD-NEEEEELGDEAMMALD 789

  Fly   810 RSF-QMFRPKSRKAQ----EKERPTKSERIDSTNLLHFRIRALDLLELFITKKPTQSVILDVLHC 869
            ::. .:|:.:..:.|    ||.:..|.:::..    .|:||||||:|:.:||:|...:||::|..
Mouse   790 QNLASLFKEQKMRIQARNEEKNKLQKEKKLRR----DFQIRALDLIEVLVTKQPEHPLILELLEP 850

  Fly   870 VFQVYSHC----AADSKLQSLREASLKLLKKILARNIELKENQSTAPILEAIEQLMSSGEEHSEE 930
            :..|..|.    .:..:.|.|...:.::....|.|  ..:......|..||:         |::
Mouse   851 LLNVIQHSMRSKGSTKQEQDLLHKTARIFMHHLCR--ARRYCHEVGPCAEAL---------HAQ- 903

  Fly   931 DQENGKQPASRQAKRDIIIWRDRCFAYLV-------SQASADG---------EPKKSAVWPLLVE 979
             .|...|.|..||...:.::......||:       ::...||         :.:..|...|.::
Mouse   904 -VERLVQQAGSQADASVALYYFNASLYLLRVLKGNTNKRHQDGHKLHGADTEDSEDQAANCLDLD 967

  Fly   980 F--------LELWVAKRRSRLSLASFEALFQSGQWQGVAP-LAVVLASHLDVQKTRSFRRAQILK 1035
            |        ||..:.||.|.|::..|.:||  .::..:.. |..|||.|: ...:|...:||...
Mouse   968 FVTRVYSASLESLLTKRNSSLTVPMFLSLF--SRYPVICKNLLPVLAQHV-AGPSRPRHQAQACL 1029

  Fly  1036 LLSE--QGRRLEVAFKDNNSSSKKFEK----------QIARYVNQLETKASSSKELNLL------ 1082
            :|.:  ..|.|.|.|:|     .::|:          |..:.:.:.::|....|||::|
Mouse  1030 MLQKTLSARELRVCFED-----PEWEQLITQLLGKATQTLQTLGEAQSKGEHQKELSILELLNTL 1089

  Fly  1083 ----------LKILAQGG---EKWQKLREQIQ 1101
                      :.:.|..|   .|.|||::.:|
Mouse  1090 LRTVNHEKLSVDLTAPLGVLQSKQQKLQQSLQ 1121

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mybbp1A	NP_476593.2	DNA_pol_phi	115..854	CDD:309870	200/880 (23%)
Mybbp1a	NP_058056.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24		5/19 (26%)
		Interaction with MYB. /evidence=ECO:0000269\|PubMed:9447996	2..580		143/683 (21%)
		DNA_pol_phi	70..835	CDD:282748	200/880 (23%)
		Nuclear export signal 1. /evidence=ECO:0000269\|PubMed:12941609	238..256		4/17 (24%)
		Nuclear export signal 2. /evidence=ECO:0000269\|PubMed:12941609	261..279		6/29 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	710..751		16/42 (38%)
		Rib_recp_KP_reg	1143..1289	CDD:282899
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1146..1344
		Required for nuclear and nucleolar localization. /evidence=ECO:0000269\|PubMed:12941609	1152..1344
		AKAP2_C	1193..>1340	CDD:291950
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1926
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S12652
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto94622
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR13213
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R341
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.980