DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mybbp1A and MYBBP1A

DIOPT Version :9

Sequence 1:	NP_476593.2	Gene:	Mybbp1A / 31010	FlyBaseID:	FBgn0001341	Length:	1133	Species:	Drosophila melanogaster
Sequence 2:	NP_001099008.1	Gene:	MYBBP1A / 10514	HGNCID:	7546	Length:	1332	Species:	Homo sapiens

Alignment Length:	1258	Identity:	264/1258 - (20%)
Similarity:	439/1258 - (34%)	Gaps:	426/1258 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   161 DLAVGSQQRGKEDSLAAVGQLVTAFCILQTPQFAKAEPK---LVTAVFQILAAQLKGRE-----Y 217
            |:|...|    |..|||..:|:         ::.:..||   :..|:.:::.....|||     |
Human    41 DIAKPEQ----ETRLAATEKLL---------EYLRGRPKGSEMKYALKRLITGLGVGRETARPCY 92

  Fly   218 LVSLCGDILAVSFKQLPAA-----IFEEYVWPLLQPELNKPLSGLKVNTCDVLLAVHLTFSSVLG 277
            .::|..  |..||:.||..     |.|:|....::..:.:|                ..|:::.|
Human    93 SLALAQ--LLQSFEDLPLCSILQQIQEKYDLHQVKKAMLRP----------------ALFANLFG 139

  Fly   278 RENILASLWPKKPVYTQLFDLYFSGSTIHSDGVYARLASFLVNGGKDMLAAWQQYIDSKQPLKL- 341
               :||              |:.||..:.......:....|     ..||.:|.:: .:||.|.
Human   140 ---VLA--------------LFQSGRLVKDQEALMKSVKLL-----QALAQYQNHL-QEQPRKAL 181

  Fly   342 -----NAAKACAIQVLSHVL---LNF---KPREEQLIL-----------------DIFT----PT 374
                 ..:||...::|..||   ||.   .|.:.:|.|                 ::|:    |.
Human   182 VDILSEVSKATLQEILPEVLKADLNIILSSPEQLELFLLAQQKVPSKLKKLVGSVNLFSDENVPR 246

  Fly   375 CVQFLLHECSSVKWDKGEGKKPSLK------KLKE-------------------------ICFKF 408
            .|..|....||||.|:   |.|::.      .|||                         :||:.
Human   247 LVNVLKMAASSVKKDR---KLPAIALDLLRLALKEDKFPRFWKEVVEQGLLKMQFWPASYLCFRL 308

  Fly   409 EGSLVLCYEKQFQNDDNKLHLLLK--LLEH------TLQL-----------DSVISLPRFCQ--- 451
            .|:.:....|:      :|||:::  ::.|      |.:|           |.|.:....||
Human   309 LGAALPLLTKE------QLHLVMQGDVIRHYGEHVCTAKLPKQFKFAPEMDDYVGTFLEGCQDDP 367

  Fly   452 -------------------------KLINQLSVESLH----------------KLYDYYNNKLYS 475
                                     :::..||..:|.                .|.|:..|....
Human   368 ERQLAVLVAFSSVTNQGLPVTPTFWRVVRFLSPPALQGYVAWLRAMFLQPDLDSLVDFSTNNQKK 432

  Fly   476 LED------EDRVSR---------VHCLNQMQLILNHSKLSQTAKWRQKQLNYLLLAGLFH-LDA 524
            .:|      |..|.|         |..::.:.|.:..:...|.|::           .||| ...
Human   433 AQDSSLHMPERAVFRLRKWIIFRLVSIVDSLHLEMEEALTEQVARF-----------CLFHSFFV 486

  Fly   525 SKKPC----EAAQASAFSRQCAAR--CEEIFLGSLLHKCS------------GLPGLCQLLQKTL 571
            :|||.    |.....:|..:..||  ....|. |||...|            |.|....|:|...
Human   487 TKKPTSQIPETKHPFSFPLENQAREAVSSAFF-SLLQTLSTQFKQAPGQTQGGQPWTYHLVQFAD 550

  Fly   572 SYLNKELGQPDAESKLRSPRDESLQKAW-KQVEKLLERPSKESDVVGQSFEALILFVSLALCTKI 635
            ..||........     :|.....::|| :.::.|.|..:..::....:|:.|:|.|.:.|....
Human   551 LLLNHSHNVTTV-----TPFTAQQRQAWDRMLQTLKELEAHSAEARAAAFQHLLLLVGIHLLKSP 610

  Fly   636 PPSITVLEDLIICRKNAL------QKSKEQVNEELKWQDVLTDALLQLLLQTGHFWREFVQLVAT 694
            ..|..:|.|:..|.:.:|      .::|....:|..|.:||.:.||.||.|..|..|:..:.|..
Human   611 AESCDLLGDIQTCIRKSLGEKPRRSRTKTIDPQEPPWVEVLVEILLALLAQPSHLMRQVARSVFG 675

  Fly   695 ALIPHLEHGNLEQVLEVLNMNKNPLSKKSDGEEESDDELDK--------EESLKDSSDDSED-ED 750
            .:..||....|:.:|:|||            .|.|:||.|:        |..||.:.|.||: ||
Human   676 HICSHLTPRALQLILDVLN------------PETSEDENDRVVVTDDSDERRLKGAEDKSEEGED 728

  Fly   751 ----EDEEEDEGEDDAESHLAQIRESVRQALVNDGDADD------------DGASSVDWNDVDEE 799
                |.|||.|||:..|..             .|||.|.            ..|...:.::.:||
Human   729 NRSSESEEESEGEESEEEE-------------RDGDVDQGFREQLMTVLQAGKALGGEDSENEEE 780

  Fly   800 QGERLNAALERSF------QMFRPKSRKAQE-KERPTKSERIDSTNLLHFRIRALDLLELFITKK 857
            .|:....||::|.      |..|.::|:.:: |.:..|:.|.|      |:||.|||:|:.:||:
Human   781 LGDEAMMALDQSLASLFAEQKLRIQARRDEKNKLQKEKALRRD------FQIRVLDLVEVLVTKQ 839

  Fly   858 PTQSVILDVLHCVFQVYSHCAADSKLQSLREASLKLLKKILARNIELKENQSTAPILEAIEQLMS 922
            |..:::|::|..:..:..        :|||.:|.|..:.:|.:...:    .|..:..|......
Human   840 PENALVLELLEPLLSIIR--------RSLRSSSSKQEQDLLHKTARI----FTHHLCRARRYCHD 892

  Fly   923 SGEE----HSEED---QENGKQPASRQA----KRDIIIWR-------DRCFAYLVSQASADGEPK 969
            .||.    |::.:   |:.|:||.|..|    ...:.:.|       :.|......:..|..:|.
Human   893 LGERAGALHAQVERLVQQAGRQPDSPTALYHFNASLYLLRVLKGNTAEGCVHETQEKQKAGTDPS 957

  Fly   970 KSAVWPLLVEFLEL-------------WVAKRRSRLSLASFEALFQSGQ--WQGVAPLAV----- 1014
            .....|.....|:|             ::.||.|.|::..|.:||....  .|.:.|:.|
Human   958 HMPTGPQAASCLDLNLVTRVYSTALSSFLTKRNSPLTVPMFLSLFSRHPVLCQSLLPILVQHITG 1022

  Fly  1015 -VLASH---LDVQKTRSFRR--------------AQILKLLSEQGRRLEVAFKDNNSSSKKFEKQ 1061
             |...|   |.:|||.|.|.              .|:|..::|..|.|      ..:.:|...:|
Human  1023 PVRPRHQACLLLQKTLSMREVRSCFEDPEWKQLMGQVLAKVTENLRVL------GEAQTKAQHQQ 1081

  Fly  1062 IARYVNQLETKASSSK------ELNLLLKILAQGGEK------------------WQKLREQIQL 1102
            ....:..|.....:.|      :|.:||.:| ||.::                  ||.::   .|
Human  1082 ALSSLELLNVLFRTCKHEKLTLDLTVLLGVL-QGQQQSLQQGAHSTGSSRLHDLYWQAMK---TL 1142

  Fly  1103 VAKDLQPNKKVAKQKKQAAAKPM 1125
            ..:..:..||.||:...|...|:
Human  1143 GVQRPKLEKKDAKEIPSATQSPI 1165

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mybbp1A	NP_476593.2	DNA_pol_phi	115..854	CDD:309870	193/905 (21%)
MYBBP1A	NP_001099008.1	Interaction with MYB. /evidence=ECO:0000250\|UniProtKB:Q7TPV4	1..582		116/620 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
		DNA_pol_phi	72..836	CDD:282748	183/861 (21%)
		Nuclear export signal 1. /evidence=ECO:0000250\|UniProtKB:Q7TPV4	240..258		4/17 (24%)
		Nuclear export signal 2. /evidence=ECO:0000250\|UniProtKB:Q7TPV4	263..281		5/17 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	698..753		23/67 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1146..1292		6/20 (30%)
		RCSD	1158..1258	CDD:282963	2/8 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1926
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D77672at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR13213
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R341
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	5.040