DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13366 and Smtnl1

DIOPT Version :9

Sequence 1:	NP_001036254.1	Gene:	CG13366 / 31004	FlyBaseID:	FBgn0025633	Length:	1094	Species:	Drosophila melanogaster
Sequence 2:	NP_077192.1	Gene:	Smtnl1 / 68678	MGIID:	1915928	Length:	459	Species:	Mus musculus

Alignment Length:	526	Identity:	119/526 - (22%)
Similarity:	201/526 - (38%)	Gaps:	164/526 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   578 SKIEELEADLSRGDKTDLSEVLDVARKEKDALEERVAELQDQCSRSQAELRRLRDQLSGLTEECK 642
            |.::||:.|| :|:.....|.      :.|..||:|.: :|..:.||.:        :|..||.|
Mouse    72 SILDELKTDL-QGEARGKDEA------QGDLAEEKVGK-EDTTAASQED--------TGKKEETK 120

  Fly   643 VVKNNAKCAVSHLEYRLEQLQRDKDKIAGEWQALEERVAELQVQCKCHQEDKAQLQSLLAETQRH 707
            ...|..:             ::::..:|.|.|.::|:...|:.:.|....|||
Mouse   121 PEPNEVR-------------EKEEAMLASEKQKVDEKETNLESKEKSDVNDKA------------ 160

  Fly   708 LGDVQLKLGEAECRLDQETQLRRKEAEEWQQFQADLLMTVRVANDFKTEALSAREQLVLDNKTQK 772
                     :.|.:.|...::...|||...|.:||:          |.:|
Mouse   161 ---------KPEPKEDAGAEVTVNEAETESQEEADV----------KDQA--------------- 191

  Fly   773 EKIRLLEQQLEKLTKQQMQQSETPQSVLSTVQREMEMATRRSKLSFSRQDSRLSVKTLI--ESIE 835
                               :.|.|:                    ...:::....|.|:  ||..
Mouse   192 -------------------KPELPE--------------------VDGKETGSDTKELVEPESPT 217

  Fly   836 NNKAQGKADESESHYSSTSSLNSGTPDLGTTPIIFPPS-SDWHESIRLPVLQSTNLHVNVGNEVG 899
            ..:.|||.:|||...:                 :.|.| .:|.||       .|:...::..:..
Mouse   218 EEQEQGKENESEERAA-----------------VIPSSPEEWPES-------PTDEGPSLSPDGL 258

  Fly   900 AGQGTNTSSGSGGDLASTTKATLPLRDQQQLAITSTQSQVQNVSQPSTPATPSSA---------G 955
            |.:.|..:|.|..:.:.:.....| .:.|.......::..:.||.||.|..|.:.         |
Mouse   259 APESTGETSPSASESSPSEVPGSP-TEPQPSEKKKDRAPERRVSAPSRPRGPRAQNRKAIMDKFG 322

  Fly   956 SSSSGGLPFGNVSKSFISGERKDPLNMLAKNGGSKRNALLKWCQNKTVGYRNIDITNFSSSWNDG 1020
            .::||  |......:..:|         |..||.| |.||:||:..|..|.::||.||||||:.|
Mouse   323 GAASG--PTALFRNTKAAG---------AAIGGVK-NMLLEWCRAMTRNYEHVDIQNFSSSWSSG 375

  Fly  1021 LAFCAILHSYLPDRIPYDQLTPANKRRNFSLAFAAAESVG-IGTTLNINDMCQIERPDWMQVMSY 1084
            :||||::|.:.|:...|.:|.||.:|.||:|||:.||.:. ....|.::||.::..||...|.:|
Mouse   376 MAFCALIHKFFPEAFDYAELDPAKRRHNFTLAFSTAEKLADCAQLLEVDDMVRLAVPDSKCVYTY 440

  Fly  1085 VTAVYK 1090
            :..:|:
Mouse   441 IQELYR 446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13366	NP_001036254.1	Ead_Ea22	554..684	CDD:290646	23/105 (22%)
CG13366	NP_001036254.1	CH	992..1092	CDD:237981	42/100 (42%)
Smtnl1	NP_077192.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..314		68/380 (18%)
		MDN1	<51..229	CDD:227596	48/270 (18%)
		PTZ00449	<150..>310	CDD:185628	43/269 (16%)
		CH	345..446	CDD:366016	42/101 (42%)
		Calmodulin-binding	441..459		1/6 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4678
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.770