DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13366 and Specc1

DIOPT Version :9

Sequence 1:	NP_001036254.1	Gene:	CG13366 / 31004	FlyBaseID:	FBgn0025633	Length:	1094	Species:	Drosophila melanogaster
Sequence 2:	XP_030101968.1	Gene:	Specc1 / 432572	MGIID:	2442356	Length:	1072	Species:	Mus musculus

Alignment Length:	1080	Identity:	309/1080 - (28%)
Similarity:	484/1080 - (44%)	Gaps:	209/1080 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 QPHSNAPEPHDPQQPLMTSLAAVPQASATGSSSNSNINNNNALAALQDGGAAAAAAADFYQQLAA 193
            :|.:.||.||.......:....:|....||..:...::...:.......|.:::      ::|.:
Mouse    88 RPLTAAPFPHRGPPRRGSRQGTIPTTKRTGIPAPRELSVTISRERSVPRGPSSS------KKLGS 146

  Fly   194 AATATATATSANGSNTSADSPVSSFPAAAAAVAVAAVAASSYQQQQQQQQLLNNEQQQQQLL-EA 257
            :.|::...|......|:...|......|..||.                     |.|.::|| ||
Mouse   147 SPTSSCNPTPTKHLRTTPAKPKQEHEGAEKAVL---------------------ESQVRELLAEA 190

  Fly   258 NNKMQELHKQMERFRSEQMQLETR---ITELL----PYQSEVAKLKGDLVKM-QSLQEKS---QM 311
            ..|..|::    |.|||..:.:.|   .||..    |.....|..:.|...: ::|:||:   |.
Mouse   191 KTKDSEIN----RLRSELKKCKERWALSTEDANASDPSAEGTASPESDAQPLIRTLEEKNKTFQK 251

  Fly   312 EIGNLKYENESLRNRLRDVVNSPLSDAEKHQIIQDSQRLHSSAPASIALPSTHDAHDGTP----- 371
            |:.:|:.||.:|:.:|..:..||.|:...      |....||.|.||    ||::..|:|
Mouse   252 ELADLEEENRALKEKLTYLEQSPNSEGAA------SHTGDSSCPTSI----THESSFGSPVGNEL 306

  Fly   372 -----------------------------CLTPD------------------------------- 376
                                         .|:||
Mouse   307 SSETDEYRRTTHGSALRTSGSSSSDVTKASLSPDASDFEHITADTPSRPLSATSNPFKSSKGSPT 371

  Fly   377 WDKQSSSSEISVACLQDKIIQMEETHYSTNEELQATLQELADLQTQLTDTQTENERLAEEKDVLF 441
            ....:::||:|:|.|.:||.:|||..:||.||||||||||:|.|..:.:...|||:|.:||.:|.
Mouse   372 GSSPNNASELSLASLTEKIQKMEENQHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILE 436

  Fly   442 QSLCRQTEKLNESRTQISTLQELLLRDTKQPAPEVSAS---EREQKLLDLIKTSQEEREAVLLKQ 503
            .|..:..|:..:...:...|..||....|...|.....   |.|||..|:::.|:.|||.:|..|
Mouse   437 TSFHQHRERAEQLSQENEKLINLLQERVKNEEPSAQGGKVLELEQKCTDILEKSRFEREKLLNIQ 501

  Fly   504 EELGAELAEMKQAREAGQLELQRQRERIALLDSQLDAANAERRQGEAQFSQAMEE----ISQRAI 564
            ::|...|.::::..:.....::..:|....|:..|:    ..|...:..::.:||    :....:
Mouse   502 QQLTCSLRKVEEENQGAIDMIKHLKEENEKLNGFLE----HERCNNSVMAKTLEECRVTLEGLKM 562

  Fly   565 EISRLSTLLENARSKIEELEADLSR-GDKTDLSEVLDVARKEKDALEERVAELQDQCSRSQAELR 628
            |...|..|||..:.|..|..:.:.: .:..::.|:|.|||.|||.|:....||:.:..::..|::
Mouse   563 ENGSLKALLEADKQKAIEASSTVGQTAENFEVQEMLKVARAEKDQLQLSCTELRQELLKANGEIK 627

  Fly   629 RLRDQLSGLTEECKVVKNNAKCAVSHLEYRLEQLQRDKDKI---AGEWQA----LEERVAELQVQ 686
            .:...|:.:.::...:|.  .|     :::.|||.|...|:   |.|..|    ::|.:.||:.|
Mouse   628 HVSSLLAKMEKDYSYLKE--VC-----DHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQ 685

  Fly   687 CKCHQEDKAQLQSLLAETQRHLGDVQLKLGEAECRLDQE----TQLRRKEAEEWQQFQADLLMTV 747
            .:.|:..|.....|::|.:   |.| :||.|.:..|:::    |:..::|.|||::|||||...|
Mouse   686 VEQHRAVKLHNNQLISELE---GSV-IKLEEQKSDLERQLKTLTKQIKEETEEWRRFQADLQTAV 746

  Fly   748 RVANDFKTEA---LSAREQLVLDNKTQKEKIRLLEQQLEKLTKQQMQQSETPQSVLSTVQREMEM 809
            .||||.|.||   |...::.:|:   ::||...|:::|..:.......:|.|:      ..|.:.
Mouse   747 VVANDIKCEAQQELRTVKRRLLE---EEEKNARLQKELGDIQGHSRPVNEEPE------PSEADA 802

  Fly   810 ATR-----RSKLSFSRQDSRLSVKTLIESIENNKAQGKADESESHYSSTSSLNSGTPDLGTTPII 869
            |.|     .::.|.:..||..:||:||:|.:...:.|.......|.:..|.| ||.| :.|.|
Mouse   803 AGRWRGVYVNRTSPAPSDSATTVKSLIKSFDLGHSGGTGQSISVHKTPRSPL-SGIP-VRTAP-- 863

  Fly   870 FPPSSDWHESIRLPVLQSTNLHVNVGNEVGAGQGTNTSSGSGGDLASTTKATLPLRDQQQLAITS 934
                        ...:.....|....:...|.:||:...    ||..     |||.|..:.....
Mouse   864 ------------AAAVSPMQRHSTYSSMKPASKGTSQRL----DLPD-----LPLSDLLKGRAED 907

  Fly   935 TQSQVQNVSQPS--TPATPSSAG-------SSSSGGLPFGNVSKSFISGERKDPLNMLAKN-GGS 989
            .:|.......||  :.:.|.|.|       |:|:|||     ..|.:|.||:|||..||:. |||
Mouse   908 RKSDPYLRKSPSLESLSRPPSLGFGNTRLLSASTGGL-----KPSKLSVERRDPLAALAREYGGS 967

  Fly   990 KRNALLKWCQNKTVGYRNIDITNFSSSWNDGLAFCAILHSYLPDRIPYDQLTPANKRRNFSLAFA 1054
            ||||||||||.||.||.|||||||||||:||||.||:||:|||..|||.:|....|:||..|||.
Mouse   968 KRNALLKWCQKKTEGYANIDITNFSSSWSDGLALCALLHTYLPAHIPYQELNSQEKKRNLLLAFE 1032

  Fly  1055 AAESVGIGTTLNINDMCQIERPDWMQVMSYVTAVYKYFET 1094
            ||:||||..:|.:::|...:||||..||.||..:||||||
Mouse  1033 AAQSVGINPSLELSEMLYTDRPDWQSVMQYVAQIYKYFET 1072

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13366	NP_001036254.1	Ead_Ea22	554..684	CDD:290646	34/141 (24%)
CG13366	NP_001036254.1	CH	992..1092	CDD:237981	62/99 (63%)
Specc1	XP_030101968.1	PHA03307	36..>151	CDD:223039	11/68 (16%)
		Smc	<165..533	CDD:224117	100/402 (25%)
		SMC_prok_B	<372..740	CDD:274008	107/382 (28%)
		PRK00409	<697..>797	CDD:234750	34/112 (30%)
		CH	969..1072	CDD:366016	65/102 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	229	1.000	Domainoid score	I2467
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	396	1.000	Inparanoid score	I1948
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45969
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002287
OrthoInspector	1	1.000	-	-		otm44031
orthoMCL	1	0.900	-	-		OOG6_104624
Panther	1	1.100	-	-	LDO	PTHR23167
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1969
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.970