DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13366 and kst

DIOPT Version :9

Sequence 1:	NP_001036254.1	Gene:	CG13366 / 31004	FlyBaseID:	FBgn0025633	Length:	1094	Species:	Drosophila melanogaster
Sequence 2:	NP_001097492.2	Gene:	kst / 38418	FlyBaseID:	FBgn0004167	Length:	4337	Species:	Drosophila melanogaster

Alignment Length:	1314	Identity:	250/1314 - (19%)
Similarity:	448/1314 - (34%)	Gaps:	431/1314 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 SHSSNSSHKQQQ---NSSNNNRQKSQSSTSLNTAHEQQQQHSITAATTKFYAHQETASYERGVDV 78
            :|...|..|:.:   |........:||.:::|....|.:.|.                 ||.|::
  Fly  2620 AHKFVSDVKELELWVNDMIKKMNNTQSPSTINDCETQLELHQ-----------------ERKVEI 2667

  Fly    79 GDEGALLLTNQQQEQ----RRQQQQLLQQPQSNTLPQKKSKLKGQKQPK-----LLPVQQPHSNA 134
              ||       :||.    ::|.:||.::||             |:||.     ||.:::.|...
  Fly  2668 --EG-------RQEAFAGLKQQGEQLSKRPQ-------------QQQPDNVRKYLLVLEELHQTL 2710

  Fly   135 PEPHDPQQPLMTSL-------AAVPQASATGSSSNSNINNNNALAALQDGGAAAAAAA---DFYQ 189
            .|....:...:|..       |.|.|.....::..:.:||::    |.|...|.....   |.::
  Fly  2711 NEAWSERARDLTEAHQLQLFKAQVEQVEIWLANKEAFLNNDD----LGDSYTAVERLLKKHDEFE 2771

  Fly   190 QLAAAATATATATSANGSNTSADSPVSSFPAAAAAV--AVAAVAASSYQQQQQQQQLLNNEQQQQ 252
            :|..|.........||       |.:...|..|..:  .:|.:.       :::|:||...::::
  Fly  2772 KLLHADHVDTLQKFAN-------SILEGEPKDADLIREKLAYIL-------RRKQKLLELSEERK 2822

  Fly   253 QLLEANNKMQELHKQM----------------ERFRSEQMQLETRITELLPYQSE---------- 291
            |.|..::::||..:.:                |.:| |...|:::|.:...:.:|
  Fly  2823 QRLTQSHQLQEFLRSLYEIDRWLVQKLQVALDENYR-EPSNLQSKIQKHAAFDAELLSNSPRVQS 2886

  Fly   292 ----------------------VAKLKGDLVKM----QSLQEKSQMEIGNLKYENESLR--NRLR 328
                                  |..|:||.:|:    |:.::|.|.....|.: |.|:.  |...
  Fly  2887 VIHEGERLIRGDHFAKDEIAQQVQLLEGDWLKLKGASQTKKDKLQQAYDALAF-NRSVDEFNNWM 2950

  Fly   329 DVVNSPLSDAE-------------KHQIIQ----------------DSQ----------RLHSSA 354
            |.|...||..:             ||:.::                |.|          .:|..|
  Fly  2951 DEVELQLSSEDYGKDLAAVSNLLKKHERLEADVAHHGELADQLKQKDEQFFQAEHFLRHEIHERA 3015

  Fly   355 PASIALPST----------------------HDAHDGTPCLTPDWDKQ-------SSSSEISVAC 390
            ..||...:|                      .||.|....|.   :||       ..:|.:||..
  Fly  3016 TVSIRRYNTLHEPLGIRRENLEDSLSLQQFLRDAEDELQWLA---EKQLVAGSQDLGTSLLSVQG 3077

  Fly   391 LQDKIIQMEETHYSTNEELQATLQELADLQTQLTDTQTENERLAEEKDVLFQSLCRQTEKLNESR 455
            ||.|...:|....|....:||.||.   .|..:.|....:|:|..:.::|.:.|.:..:
  Fly  3078 LQKKHNSLEAELTSQEPLIQALLQR---GQQMIRDNHFASEQLQYKSELLQKQLVQLRD------ 3133

  Fly   456 TQISTLQELLLRDTKQ------PAPEVSASEREQKLLDLIKTSQEEREAVLL-----KQEELGAE 509
              ::.::.|.|.|..:      .|.|..|..||::  .::.:|...|:.|.:     |.|.|..|
  Fly  3134 --LAAIRRLRLLDAVESQLFYVEANEADAWMREKR--PVLSSSDYGRDEVSVQGHQKKLEVLQRE 3194

  Fly   510 LAEMKQARE------AGQLELQR-QRERIALLDSQLD---------AANAERRQGEA----QFSQ 554
            |...|.:.|      .|.:|... ....||..::|:.         |...|.|.||.    ::.:
  Fly  3195 LTAFKPSIEKVAKLATGLIERNHFDSSNIAEKNAQVGQEYEDLLRLAKERESRLGECKKLFEYLR 3259

  Fly   555 AMEEI-----SQRAIEISR---------------LSTLLENARSKIEELEADLSRGD-------- 591
            ..||:     .|.|:..|.               ..:.:.|..:....:||.|.|||
  Fly  3260 ETEELHEWVGDQMAVTASEDYGEDVEHVEQLILAFESFVSNLNANEARVEACLERGDRLIQENNP 3324

  Fly   592 -------KTD-----LSEVLDVARKEKDALE--------ERVAELQDQCSRS------------- 623
                   |.|     ..|:.|:....:|||.        :|||:...|....
  Fly  3325 YRSSIKSKRDETKQLWEELKDLVHARQDALAGAKQVHVYDRVADETIQLINEKDASLISEDYGQD 3389

  Fly   624 --------------QAELRRLRDQLSGLTEECKVVKNNAKCAVSHLEYRLEQLQRDKDKIAGEWQ 674
                          ::||..::.|:..:..|...:......|..|:|.:       :|:....|.
  Fly  3390 LESIQALGRKHQVFESELVGIQGQVDSVLAEAAKLGEIYPDAKEHIEVK-------RDETVEAWT 3447

  Fly   675 ALEERVA----------ELQVQCKCHQEDKAQLQSLLA-----ETQRHLGDVQLKLGEAECRLDQ 724
            .|:|:.|          :||.....:::..|.:..:||     |....:...:|.|...:   |.
  Fly  3448 DLKEKTAARKNKLSQAEQLQSYFDEYRDLIAWINEMLAKITAPELANSVAGAELLLASTK---DH 3509

  Fly   725 ETQLRRKEAEEWQQFQADLLMTVR----VANDF--KTEALSAREQLV--------------LDNK 769
            :|::|.:: |.:.:|.|:....::    :|::.  |.:.|.||.:|:              ||.:
  Fly  3510 DTEIRTRD-ETFAKFAANGQQLIKEKHFLAHEVEDKIKVLQARHELLKHTLNKRREIYELNLDTQ 3573

  Fly   770 TQKEKIRLLEQ-------------------QLEKLTKQQ-------MQQSETPQSV--LSTVQRE 806
            ...:...:|||                   |:|.|.::.       ..|.|..|::  ::.:::.
  Fly  3574 LFLKDAEILEQWISSREPQLKDTKLGDSIPQVEDLLRRHEDFEKTVAAQEEKFQAIKRITMLEQL 3638

  Fly   807 MEMATRRSKLSFSRQDSRLSVKTLIESIENNKAQGKAD-----ESESHYSSTSSLNSGTPDLGTT 866
            ......:.|:|..::..||. |..:|.::..:.|..||     |.:..:...::....|| :.::
  Fly  3639 FRHQLEQEKISKLQEKERLE-KERLEQLKQRELQRLADERRRAEKQHEHRQNAASQEKTP-IFSS 3701

  Fly   867 PIIFPPSSDWHESIRLPVLQSTNLHVNVG--NEVGAGQGTNTSSGSGGDLASTTKATLPLRDQQQ 929
            |::.|..:...:|   |.|....|....|  ||..|.| .::|||..||......|...::..:.
  Fly  3702 PMVTPAQTSGPQS---PALSQVQLRPPFGDDNEHLALQ-KSSSSGMFGDRLRRGSADANVKRAES 3762

  Fly   930 LAITSTQSQVQNVSQPS--TPATPSSAGSSSSG---GLPFGNVSKSFISGERKDPLNMLAKNGGS 989
            :.:...|::    ..||  |.....|...:..|   .||...:..|.   |||..|     ..|.
  Fly  3763 MKVQPKQAK----RTPSFTTRRRAQSFRKNQKGEGFDLPPVEIQGSL---ERKHGL-----QSGG 3815

  Fly   990 KRNALLKWCQNKTV 1003
            |:..:..|.|..||
  Fly  3816 KKAPVRSWKQFHTV 3829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13366	NP_001036254.1	Ead_Ea22	554..684	CDD:290646	35/214 (16%)
CG13366	NP_001036254.1	CH	992..1092	CDD:237981	4/12 (33%)
kst	NP_001097492.2	CH	76..178	CDD:237981
		CH	197..303	CDD:237981
		SPEC	450..640	CDD:238103
		SPEC	658..832	CDD:238103
		SH3	885..935	CDD:214620
		SPEC	1030..1236	CDD:238103
		SPEC	1134..1341	CDD:238103
		SPEC	1343..1551	CDD:238103
		SPEC	1449..1658	CDD:238103
		SPEC	1555..1764	CDD:238103
		SPEC	1765..1975	CDD:238103
		SPEC	1873..2080	CDD:238103
		SPEC	1979..2185	CDD:238103
		SPEC	2188..2402	CDD:238103
		SPEC	2407..2618	CDD:238103
		SPEC	2514..2725	CDD:238103	29/143 (20%)
		SPEC	2726..2934	CDD:238103	38/226 (17%)
		SPEC	2935..3145	CDD:238103	43/224 (19%)
		SPEC	3042..3251	CDD:238103	51/224 (23%)
		SPEC	3149..3357	CDD:238103	44/209 (21%)
		SPEC	3359..3567	CDD:238103	36/218 (17%)
		SPEC	3465..3680	CDD:238103	40/219 (18%)
		PH	3799..3902	CDD:278594	11/39 (28%)
		PH_beta_spectrin	3801..3904	CDD:269975	11/37 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23167
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100