DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13366 and Specc1

DIOPT Version :9

Sequence 1:	NP_001036254.1	Gene:	CG13366 / 31004	FlyBaseID:	FBgn0025633	Length:	1094	Species:	Drosophila melanogaster
Sequence 2:	XP_006246564.2	Gene:	Specc1 / 303208	RGDID:	1309718	Length:	1058	Species:	Rattus norvegicus

Alignment Length:	1130	Identity:	308/1130 - (27%)
Similarity:	487/1130 - (43%)	Gaps:	242/1130 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   126 PVQQPHSNAPEPHDPQQPL------------MTSLAAVPQASATGSSSNSNINN-----NNALAA 173
            ||.:..|:.|   |..:||            .||||...:.|....:|:.::.|     ::.:|.
  Rat    10 PVAKAGSHGP---DRTRPLPGTPSGMKSSKSSTSLAFESRLSKLKRASSEDMLNKPGSASSGVAR 71

  Fly   174 LQDGGAAAAAAADFYQQLAAAATATATATSANG------------------SNTSADSPVSSFPA 220
            |:. .:.:.|.::..:....:.|.|...|...|                  ...|:...:.|.|.
  Rat    72 LKK-TSTSGAISELTESRLRSNTGTIPTTKRTGIPAPRELSVTISRERSVPRGPSSSKKLGSSPT 135

  Fly   221 AAA----AVAVAAVAASSYQQQQQQQQLLNNEQQQQQLLEANNKMQELHKQMERFR--SEQMQLE 279
            ::.    ...:....|...|:.:..::.:...|.::.|.||..|..|:::.....:  .|:..|.
  Rat   136 SSCNPTPTKHLRTTPAKPKQEHEGTEKAVLESQVRELLAEAKTKDSEINRLRSELKKCKERWALG 200

  Fly   280 TRITELLPYQSEVAKLKGDLVK--MQSLQEKS---QMEIGNLKYENESLRNRLRDVVNSPLSDAE 339
            |..:......:|...:.|...:  :::|:||:   |.|:.:|:.||.:|:.:|..:..||.|:..
  Rat   201 TEDSNASDPSTEGTSVPGSDTEPLIRTLEEKNKTFQKELADLEEENRALKEKLTYLEQSPNSEGA 265

  Fly   340 KHQIIQDSQRLHSSAPASIALPSTHDAHDGTP--------------------------------- 371
            .      |....||.|.||    ||::..|:|
  Rat   266 A------SHTGDSSCPTSI----THESSFGSPVGNELSSETDEYRRNTHGSALRTSGSSSSDVTK 320

  Fly   372 -CLTPD-------------------------------WDKQSSSSEISVACLQDKIIQMEETHYS 404
             .|:||                               ....:::||:|:|.|.:||.:|||..:|
  Rat   321 ASLSPDASDFEHITADTPSRPLSATSNPFKSSKGSPTGSSPNNASELSLASLTEKIQKMEENQHS 385

  Fly   405 TNEELQATLQELADLQTQLTDTQTENERLAEEKDVLFQSLCRQTEKLNESRTQISTLQELLLRDT 469
            |.||||||||||:|.|..:.:...|||:|.:||.:|..|..:..|:..:...:...|..||....
  Rat   386 TAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLINLLQERV 450

  Fly   470 KQPAPEVSAS---EREQKLLDLIKTSQEEREAVLLKQEELGAELAEMKQAREAGQLELQRQRERI 531
            |...|.....   |.|||..|:::.|:.|||.:|..|::|...|.::::..:.....::..:|..
  Rat   451 KNEEPSAQGGKILELEQKCTDILEKSRFEREKLLNIQQQLTCSLRKVEEENQGAIDMIKHLKEEN 515

  Fly   532 ALLDSQLDAANAERRQGEAQFSQAMEE----ISQRAIEISRLSTLLENARSKIEELEADLSR-GD 591
            ..|...|:    ..|...:..::.:||    :....:|...|...||..:.|..|..:.:.: .:
  Rat   516 EKLSGFLE----HERCNNSVMAKTLEECRVTLEGLKMENGSLKAHLEADKQKAVEASSTMGQTAE 576

  Fly   592 KTDLSEVLDVARKEKDALEERVAELQDQCSRSQAELRRLRDQLSGLTEECKVVKNNAKCAVSHLE 656
            ..::.|:|.|||.|||.|:....||:.:..::..|::.:...|:.:.::...:|.  .|     :
  Rat   577 NFEVQEMLKVARAEKDQLQLSCTELRQELLKANGEIKHVSSLLAKMEKDYSYLKE--VC-----D 634

  Fly   657 YRLEQLQRDKDKI---AGEWQA----LEERVAELQVQCKCHQEDKAQLQSLLAETQRHLGDVQLK 714
            ::.|||.|...|:   |.|..|    ::|.:.||:.|.:.|:..|.....|::|.:..:..::.:
  Rat   635 HQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVVKLEEQ 699

  Fly   715 LGEAECRLDQETQLRRKEAEEWQQFQADLLMTVRVANDFKTEALSAREQLVLDNKTQKEKIRLLE 779
            ..:.|.:|...|:..::|.|||::|||||...|.||||.|.||         ..:.:..|.||||
  Rat   700 KSDLERQLKTLTKQIKEETEEWRRFQADLQTAVVVANDIKCEA---------QQELRTVKRRLLE 755

  Fly   780 QQLEKLTKQQMQQSETPQSVLSTVQREMEM----ATRR------SKLSFSRQDSRLSVKTLIESI 834
            :: ||..:.|.:..:. |.....|..|.|.    |..|      ::.|.:..||..:||:||:|.
  Rat   756 EE-EKNARLQKELGDI-QGHSRPVNEEAEPSEVDAAGRWRGVYVNRTSPAPSDSATTVKSLIKSF 818

  Fly   835 ENNKAQGKADESESHYSSTSSLNSGTPDLGTTPI--------------IFPPSSDWHESIRLPVL 885
            :...:.|.......|.:..|.| ||.| :.|.|.              :.|.|....:.:.||
  Rat   819 DLGHSGGTGQSISVHKTPRSPL-SGIP-VRTAPAAAVSPMQRHSTYSSMRPASKGMSQRLDLP-- 879

  Fly   886 QSTNLHVNVGNEVGAGQGTNTSSGSGGDLASTTKATLPLRDQQQLAITSTQSQVQNVSQPSTPAT 950
                                               .|||.|   |....|:.:   .|.|....:
  Rat   880 -----------------------------------DLPLSD---LLKGRTEDR---KSDPYLRKS 903

  Fly   951 PSSAGSSSSGGLPFGN----------VSKSFISGERKDPLNMLAKN-GGSKRNALLKWCQNKTVG 1004
            ||....|....|.|||          :..|.:|.||:|||..||:. |||||||||||||.||.|
  Rat   904 PSLESLSRPPSLGFGNTRLLSASTGGLKPSKLSVERRDPLAALAREYGGSKRNALLKWCQKKTEG 968

  Fly  1005 YRNIDITNFSSSWNDGLAFCAILHSYLPDRIPYDQLTPANKRRNFSLAFAAAESVGIGTTLNIND 1069
            |.|||||||||||:||||.||:||:|||..|||.:|....|:||..|||.|||||||..:|.:::
  Rat   969 YANIDITNFSSSWSDGLALCALLHTYLPAHIPYQELNSQEKKRNLLLAFEAAESVGIKPSLELSE 1033

  Fly  1070 MCQIERPDWMQVMSYVTAVYKYFET 1094
            |...:||||..||.||..:||||||
  Rat  1034 MLYTDRPDWQSVMQYVAQIYKYFET 1058

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13366	NP_001036254.1	Ead_Ea22	554..684	CDD:290646	33/141 (23%)
CG13366	NP_001036254.1	CH	992..1092	CDD:237981	63/99 (64%)
Specc1	XP_006246564.2	Mplasa_alph_rch	<363..782	CDD:275316	125/440 (28%)
Specc1	XP_006246564.2	CH_CYTSB	946..1057	CDD:409106	71/110 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	226	1.000	Domainoid score	I2430
eggNOG	1	0.900	-	-		E2759_KOG4678
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	393	1.000	Inparanoid score	I1910
OMA	1	1.010	-	-		QHG45969
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002287
OrthoInspector	1	1.000	-	-		otm46121
orthoMCL	1	0.900	-	-		OOG6_104624
Panther	1	1.100	-	-	LDO	PTHR23167
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1969
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.870