DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13366 and smtn

DIOPT Version :9

Sequence 1:	NP_001036254.1	Gene:	CG13366 / 31004	FlyBaseID:	FBgn0025633	Length:	1094	Species:	Drosophila melanogaster
Sequence 2:	XP_017946876.2	Gene:	smtn / 100216161	XenbaseID:	XB-GENE-951898	Length:	1051	Species:	Xenopus tropicalis

Alignment Length:	1070	Identity:	233/1070 - (21%)
Similarity:	396/1070 - (37%)	Gaps:	301/1070 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   233 SSYQQQQQQQQLLNNEQQQQQLLEA-------NNKMQELHKQMERFR--SEQMQLETRITELLPY 288
            |..|:.::.|...:.|:|||:.|.|       .|.::||...:...:  .|:..:...|.::...
Frog    59 SHEQENKENQPRADREEQQQRALNALTIRLQNINDLEELTSLLRNSKEYEERKLIRAAIRKVRND 123

  Fly   289 QSEVAKLKGDLVKMQSLQE------KSQMEIGN----LKYENESLRNR---------LRDVVN-- 332
            :.|.|.|.|.|::..|.::      |||..:||    |..|.|.|..|         ||...|
Frog   124 EIEAASLGGMLIRQSSERDNGKLVCKSQDAVGNLVPSLAQEREDLEERQKIRAQIHELRSAQNGG 188

  Fly   333 SPLSDAEKHQIIQDSQRLHSSAPASIALPSTHDAHDGTPCLTPDWDKQSSSSEISVACLQDKIIQ 397
            |.::.:::   |:.:..|....|....|||:..:...|...|....:.||||......|.....:
Frog   189 SHIAGSKE---IESNMLLRLKVPTKEQLPSSTSSSSSTSSFTSFSSEPSSSSHCQATELLSLSAE 250

  Fly   398 ME-ETHYSTNEELQATLQELADLQTQLTDTQTENERLAEEKDVLFQSLCRQTEKLNESRTQI--- 458
            .| :.|.:.||.......|.:..:|:    :..|..:|..|         |..|..:....:
Frog   251 FEGQPHNNRNEVFMEPSAEDSGTETR----EQPNTHVASHK---------QNVKSEQKPLPVWTG 302

  Fly   459 ---STLQELLLRDTKQPAPE----VSASE-----------REQKLLDLIKTSQEEREAVL----- 500
               |.:...|..|.|:..||    .|.||           |...:.|.:|...||..:|.
Frog   303 RADSHIISRLGADNKESFPEGVTSASCSEPDDQTSMPPFRRAYSVRDRVKKFSEESSSVTTPALG 367

  Fly   501 -----LKQEEL---GAELAEMKQAREAGQLELQRQRERIALLDSQ-------------------- 537
                 ::.|..   ||.:.:.......||...|:..:....:..|
Frog   368 FRFGSMRAERAPVRGAHVLQQHSLLSVGQENNQKAAQNARFVTKQEVTRTVSGPCTRRLDGIPTA 432

  Fly   538 ------------------LDAANAERRQGEAQFSQ-----AMEEISQRAIEISRLSTLLE--NAR 577
                              |:.:.:...:|.:..|.     :..|:: |.:..|:.|.:|:  :.|
Frog   433 GTQSTNKIQSFKSPFIPELNNSRSTSLKGSSSLSSTGPCTSSREVN-RGLPQSQGSFILKQNSGR 496

  Fly   578 SKIEELEADLSRGDKTDLSEVLDVARKE---------------KDALEER---------VAELQD 618
            |:..:|:..|...::..:.|..|.|..|               |...||.         ..|::|
Frog   497 SQENQLKVPLPMTERGRIDENSDGANTEGPGSLQSSTHLCKSTKGTREETEDTDMKTLLTIEIKD 561

  Fly   619 ------------QCSRSQAEL----------------------------RRLRDQL-----SGLT 638
                        |....:|||                            |.:|.:.     ||:|
Frog   562 GRNQTTSSRVVGQPGNQRAELMLGLTSSPFRINSGFSTSNDGASSGITTRSIRTETRTTTQSGIT 626

  Fly   639 EECKVVKNNAKCAVSHLEYRLEQLQRDKDKIAG-EWQALEERVAEL------------QVQCKCH 690
            ....|:|...:....|   ::|:..:|:.:.:| |..|:....||.            :|:.:..
Frog   627 SSSNVIKEKKRLRSDH---QMEERDQDRQQCSGEEGSAVSSVPAEAPLSDSTCGGDIGEVEAETP 688

  Fly   691 QEDKAQLQSLL-AETQRHLGDVQLKLGEAECRLDQETQLRRKEAEEWQQFQADLLMTVRVA-NDF 753
            ||...||:..| :.|::...:.:.||...:....:|.::..|..::...|:...|  :|.| .|.
Frog   689 QETPQQLEVFLPSTTEKAEPENKGKLTAEDLNAIEEEEVLDKMLDKATDFEERKL--IRAAMRDL 751

  Fly   754 KTEALSAREQLVLDNKTQKEKIRLLEQQLEKLTKQQMQQSETPQ--SVLSTVQREMEMATRRSKL 816
            :......||: ..:.:.|:.|.:..|.||.:.|:..::||||..  |.:|||       |:..:|
Frog   752 RQRKREQREK-EREQRLQELKNKERESQLARSTETSIRQSETTNHGSAVSTV-------TKTQRL 808

  Fly   817 SFSRQDSRLSVKTLIESIENNKAQGKADESESHYSSTSSLNSGTPDLGTTPIIFPPSSDWHESIR 881
            ..|...|:.|..|.:|:    ....:::..::...:.||.::.:..:|:   ||....:
Frog   809 VQSNDGSKTSSTTTLEA----SYMKRSENGDTIVQTKSSFSATSKKVGS---IFDREDE------ 860

  Fly   882 LPVLQSTNLHVNVGNEVGAGQGTNTSSGSGGDLASTTKATLPLRDQQQLAITSTQSQVQNVSQPS 946
                                           .|:.....|...|.|.:......::|    |.|.
Frog   861 -------------------------------GLSRANSMTAMERRQAERKKELMKAQ----SLPK 890

  Fly   947 TPATPS-----------SAGSSSSGGLPFGNVS--KSFISGERKDPLNMLAKNGGSKRNALLKWC 998
            ||||.:           |.||||..   |..|:  :|...|         ..|..|.:..||.||
Frog   891 TPATQARKAMIEKMEKESGGSSSPA---FAKVATPRSAAFG---------VPNANSIKQMLLDWC 943

  Fly   999 QNKTVGYRNIDITNFSSSWNDGLAFCAILHSYLPDRIPYDQLTPANKRRNFSLAFAAAES-VGIG 1062
            :.||.||.:::|.||||||:||:||||::|::.|:...|:||.|.|:|:||.|||:|||. |...
Frog   944 KAKTRGYEHVNIQNFSSSWSDGMAFCALVHNFFPEAFDYNQLNPQNRRKNFDLAFSAAEMLVDCV 1008

  Fly  1063 TTLNINDMCQI-ERPDWMQVMSYVTAVYKY 1091
            ..:.:.||..: :|||...|.:||.::|.:
Frog  1009 PLVEVEDMMIMGKRPDSKCVFTYVQSLYNH 1038

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13366	NP_001036254.1	Ead_Ea22	554..684	CDD:290646	37/218 (17%)
CG13366	NP_001036254.1	CH	992..1092	CDD:237981	47/102 (46%)
smtn	XP_017946876.2	Smoothelin	<10..41	CDD:403640
		Smoothelin	75..121	CDD:403640	10/45 (22%)
		Smoothelin	706..755	CDD:403640	9/50 (18%)
		CH_SMTNA	934..1044	CDD:409107	48/105 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910