Protein Alignment vnd and NKX6-2

DIOPT Version :10

• Sequence 1: NP_476786.2
• Gene: vnd / 31003
• FlyBaseID: FBgn0261930
• Length: 723
• Species: Drosophila melanogaster
• Sequence 2: NP_796374.2
• Gene: NKX6-2 / 84504
• HGNCID: 19321
• Length: 277
• Species: Homo sapiens
• Alignment Length: 262
• Identity: 62/262 - (23%)
• Similarity: 90/262 - (34%)
• Gaps: 89/262 - (33%)

  Fly   370 NFPGSF---GDEMSSYHHMAQTMLQHSGRSAWIKENELYGTQQPASPDSTSPVTSEVSYTYIGSN 431
            |.||:|   ...:::.|:||:..                              ||...|...|..
Human     4 NRPGAFVLSSAPLAALHNMAEMK------------------------------TSLFPYALQGPA 38

  Fly   432 CQTSPALSGDYKSYSRSADSDALSVGDALHTLH----------GSSGNGSAGGAPTAHALHNNNN 486
            ...:|||.|             |.....|.|.|          |::|.|..||.|..:.|
Human    39 GFKAPALGG-------------LGAQLPLGTPHGISDILGRPVGAAGGGLLGGLPRLNGL----- 85

  Fly   487 NTTNNNNHSLKAEGI-----NGAGSGHDDSLNE---------DGIEEDID--DVDDADGSGGGDA 535
                     ..:.|:     .....|:...|.|         .|:.:...  |...|..:..|..
Human    86 ---------ASSAGVYFGPAAAVARGYPKPLAELPGRPPIFWPGVVQGAPWRDPRLAGPAPAGGV 141

  Fly   536 NGSDGLPNKKRKRRVLFTKAQTYELERRFRQQRYLSAPEREHLASLIRLTPTQVKIWFQNHRYKT 600
            ...||   ||:..|..|:..|.:.||:.|.|.:||:.|||..||..:.:|.:|||:||||.|.|.
Human   142 LDKDG---KKKHSRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKW 203

  Fly   601 KR 602
            ::
Human   204 RK 205

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
vnd	NP_476786.2	Homeodomain	546..602	CDD:459649	24/55 (44%)
NKX6-2	NP_796374.2	Repressor domain. /evidence=ECO:0000250|UniProtKB:D3Z4R4	89..142		8/52 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	132..155		7/25 (28%)
		Homeodomain	147..205	CDD:459649	26/57 (46%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	210..250