| Sequence 1: | NP_476786.2 | Gene: | vnd / 31003 | FlyBaseID: | FBgn0261930 | Length: | 723 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_082292.1 | Gene: | Nanog / 71950 | MGIID: | 1919200 | Length: | 305 | Species: | Mus musculus |
| Alignment Length: | 179 | Identity: | 50/179 - (27%) |
|---|---|---|---|
| Similarity: | 85/179 - (47%) | Gaps: | 6/179 - (3%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 454 LSVG-DALHTLHGSSGNGSAGGAPTAHALHNNNNNT--TNNNNHSLKAEGINGAGSGHDDSL--N 513
Fly 514 EDGIEEDIDDVDDADGSGGGDANGSDGLPNKKRKRRVLFTKAQTYELERRFRQQRYLSAPEREHL 578
Fly 579 ASLIRLTPTQVKIWFQNHRYKTKRAQNEKGYEGHPGLLHGHATHPHHPS 627 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| vnd | NP_476786.2 | Homeodomain | 546..602 | CDD:459649 | 24/55 (44%) |
| Nanog | NP_082292.1 | Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1..30 | 9/28 (32%) | |
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 46..95 | 8/49 (16%) | |||
| Sufficient for interaction with SALL4. /evidence=ECO:0000269|PubMed:16840789 | 96..155 | 27/58 (47%) | |||
| Homeodomain | 98..153 | CDD:459649 | 24/54 (44%) | ||
| Required for DNA-binding. /evidence=ECO:0000250|UniProtKB:Q9H9S0 | 123..152 | 12/28 (43%) | |||
| PTZ00395 | <190..>250 | CDD:185594 | |||
| 10 X repeats starting with a Trp in each unit | 198..247 | ||||
| Sufficient for transactivation activity | 198..247 | ||||
| Sufficient for strong transactivation activity | 248..305 | ||||
| Blue background indicates that the domain is not in the aligned region. | |||||