Protein Alignment vnd and NKX2-1

DIOPT Version :10

• Sequence 1: NP_476786.2
• Gene: vnd / 31003
• FlyBaseID: FBgn0261930
• Length: 723
• Species: Drosophila melanogaster
• Sequence 2: NP_001073136.1
• Gene: NKX2-1 / 7080
• HGNCID: 11825
• Length: 401
• Species: Homo sapiens
• Alignment Length: 509
• Identity: 149/509 - (29%)
• Similarity: 183/509 - (35%)
• Gaps: 182/509 - (35%)

  Fly   240 SGHRGQ--------GSHTSPSALS-----------PTPAGVS-----ADEHHNGSG-TGGGAGEA 279
            ||..|:        |..:||..||           .||..||     .:|.:...| .|||.|..
Human     3 SGGSGKARGWEAAAGGRSSPGRLSRRRIMSMSPKHTTPFSVSDILSPLEESYKKVGMEGGGLGAP 67

  Fly   280 DHHSTTEHHAPPSHPQQQHPHHQQHHHPHLLLPQQHHQQAVAPLPLAHHQSGEAQSHAHANAAAA 344
            .........|||:...|||                         .:.||  |...:..|..||..
Human    68 LAAYRQGQAAPPTAAMQQH-------------------------AVGHH--GAVTAAYHMTAAGV 105

  Fly   345 HLLASHNAAAAAAVAAGQYLPNLPKNFPGSFGDEMSSYHHMAQTMLQHSGRSAWIKENELYGTQQ 409
            ..| ||:       |.|.|.       .|:.|: ||.......||...:....|      ||
Human   106 PQL-SHS-------AVGGYC-------NGNLGN-MSELPPYQDTMRNSASGPGW------YG--- 145

  Fly   410 PASPDSTSPVTSEVSYTYIGSNCQTSPALSGDYKSYSRSADSDALSVGDALHTLHGSSGNGSAGG 474
             |:||...|..|.    ::|
Human   146 -ANPDPRFPAISR----FMG--------------------------------------------- 160

  Fly   475 APTAHALHNNNNNTTNNNNHSLKAEGINGAGSGHDDSLNEDGIEEDIDDVDDADGSGGGDANGSD 539
                                  .|.|:|.:|.|        |:           ||.|..:....
Human   161 ----------------------PASGMNMSGMG--------GL-----------GSLGDVSKNMA 184

  Fly   540 GLPN-KKRKRRVLFTKAQTYELERRFRQQRYLSAPEREHLASLIRLTPTQVKIWFQNHRYKTKRA 603
            .||: .:|||||||::||.|||||||:||:||||||||||||:|.||||||||||||||||.||.
Human   185 PLPSAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQ 249

  Fly   604 QNEKGYE-------GHPGLLHGHATHPHHPSALPSPRRVAVPVLVRNGKPCLGDSSKLGADCVSV 661
            ..:|..:       |..|...|........:...|||||||||||::||||     :.||.....
Human   250 AKDKAAQQQLQQDSGGGGGGGGTGCPQQQQAQQQSPRRVAVPVLVKDGKPC-----QAGAPAPGA 309

  Fly   662 SSATATAMQNAAAHHLVALNGAAAYQHAAAAAAGLHAHAHAHAHAHGHGHPHAH 715
            :|....|.|. |.|...|...|||.....:..|||.||......:.|.....||
Human   310 ASLQGHAQQQ-AQHQAQAAQAAAAAISVGSGGAGLGAHPGHQPGSAGQSPDLAH 362

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
vnd	NP_476786.2	Homeodomain	546..602	CDD:459649	47/55 (85%)
NKX2-1	NP_001073136.1	Homeodomain	192..248	CDD:459649	47/55 (85%)