Protein Alignment vnd and Nkx1-1

DIOPT Version :10

• Sequence 1: NP_476786.2
• Gene: vnd / 31003
• FlyBaseID: FBgn0261930
• Length: 723
• Species: Drosophila melanogaster
• Sequence 2: NP_035450.1
• Gene: Nkx1-1 / 672284
• MGIID: 109346
• Length: 440
• Species: Mus musculus
• Alignment Length: 508
• Identity: 121/508 - (23%)
• Similarity: 150/508 - (29%)
• Gaps: 220/508 - (43%)

  Fly   238 STSGHRGQGSHTSPSALSPTPAGVSADEHHNGSGTGGGAGEADHHSTTEHHAP-PSHPQQQHPHH 301
            ||||....|   ...||.|.|.|       .|||....|..|....|.:..|. |..|
Mouse     2 STSGPAAPG---DVPALPPPPPG-------PGSGPAPPAPAATARDTMDGRAELPIFP------- 49

  Fly   302 QQHHHPHLLLPQQHHQQAVAPLPLAHHQSGEAQSHAHANAAAAHLLASHNAAAAAAVAAGQYLPN 366
                           :..|.||                 ||:..:.|....|.||..||    |.
Mouse    50 ---------------RAGVPPL-----------------AASDTVPAVPEGAGAARPAA----PP 78

  Fly   367 LPKNF-------PGSFGDEMSSYHHMAQTMLQHSGRSAWIKENELYGTQQPASPDSTSPVTSEVS 424
            .|.:|       |..|                :|.|...:    |.|...||:....:|..
Mouse    79 RPTSFSVLDILDPNKF----------------NSRRRRCV----LLGPVVPATCAPCAPAA---- 119

  Fly   425 YTYIGSNCQTSPALSGDYKSYSRSADSDALSVGDALHTLHGSSGNGSAGGAPTAHALHNNNNNTT 489
                   |...||.||  :|.....:..|||         .::|..:|.||....|..:...:..
Mouse   120 -------CVAVPAASG--RSPRAELERRALS---------AATGVAAAAGAEPTSAGDSYRADEA 166

  Fly   490 NNNNHSLKAEGINGAGSGH------DDSLNEDGIEEDIDDVDDADG------------------- 529
            ..|.:|        :|||.      :|...||..||:..:|.||.|
Mouse   167 EANGYS--------SGSGRSPTADSEDEAPEDEDEEEAPEVQDAQGTEEPRGGSGGLGARGSGCP 223

  Fly   530 --------------------------------SGGGDA-----------------NGSDGLPNKK 545
                                            :|.|.|                 .|||....|.
Mouse   224 GAAEVEASPVDDTAAPGPRGNSPGAPGPPATATGAGSAGSTPQGAAVTTKPKRKRTGSDSKSGKP 288

  Fly   546 RKRRVLFTKAQTYELERRFRQQRYLSAPEREHLASLIRLTPTQVKIWFQNHRYKTKRAQN----- 605
            |:.|..||..|...||.:|:..||||..||.:||..:.||.|||||||||.|.|.|: ||
Mouse   289 RRARTAFTYEQLVALENKFKATRYLSVCERLNLALSLSLTETQVKIWFQNRRTKWKK-QNPGADT 352

  Fly   606 --EKGYEGHPG--------------------------LLHGHATHP-HHPSAL 629
              ..|..|.||                          .|||.|.:| |.|..|
Mouse   353 SAPTGGGGGPGPGAGPGAGLPGGLSPLSPSPPMGAPLALHGPAGYPAHSPGGL 405

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
vnd	NP_476786.2	Homeodomain	546..602	CDD:459649	29/55 (53%)
Nkx1-1	NP_035450.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..82		32/132 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	145..291		27/153 (18%)
		Homeodomain	289..345	CDD:459649	29/55 (53%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	342..387		8/45 (18%)