Protein Alignment vnd and lbx2

DIOPT Version :10

• Sequence 1: NP_476786.2
• Gene: vnd / 31003
• FlyBaseID: FBgn0261930
• Length: 723
• Species: Drosophila melanogaster
• Sequence 2: NP_001007135.1
• Gene: lbx2 / 64276
• ZFINID: ZDB-GENE-001206-2
• Length: 257
• Species: Danio rerio
• Alignment Length: 231
• Identity: 66/231 - (28%)
• Similarity: 91/231 - (39%)
• Gaps: 51/231 - (22%)

  Fly   380 SSYHHMAQTMLQHSGRSAWIKENELYG--TQQPASPDSTSPVTSEVSYTYIGSNCQTSPALSGDY 442
            ||....|.::||.||      |....|  .|.|...:|..|:|     .:...:....|
Zfish     4 SSKDMKAGSVLQSSG------EERRRGPLDQLPPPANSNKPLT-----PFSIEDILNKP------ 51

  Fly   443 KSYSRSADSDALSVGDALHTLHGSSGNGSAGGAPTAH--ALHNNNNNTTNNNNHSLKAEGINGAG 505
             |..:|..|  |.....|..:.|||.:.:...||::.  ||....:.|..
Zfish    52 -SVKKSVGS--LCPPRVLEKVTGSSASRNGISAPSSPLCALEELASKTFK--------------- 98

  Fly   506 SGHDDSLNEDGIEEDIDDVDDADGSGGGDANGSDGLPNKKRKRRVLFTKAQTYELERRFRQQRYL 570
                      |:|..:  :..|:|....:|.|......|:||.|..||..|.||||:||..|:||
Zfish    99 ----------GLEVSV--IQAAEGREHINAFGQRQASKKRRKSRTAFTNHQIYELEKRFLYQKYL 151

  Fly   571 SAPEREHLASLIRLTPTQVKIWFQNHRYKTKRAQNE 606
            |..:|:.:|..:.||..||..||||.|.|.||...|
Zfish   152 SPADRDQIAQQLGLTNAQVITWFQNRRAKLKRDLEE 187

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
vnd	NP_476786.2	Homeodomain	546..602	CDD:459649	28/55 (51%)
lbx2	NP_001007135.1	Required for convergent extension movement and hypaxial myogenesis during gastrulation. Required for the formation of thick and thin myofilaments. Required for myod1 expression in the pectoral fin bud. Required for continuous expression of cxcl12a in the posterior lateral mesoderm at the tail bud stage and in adaxial cells at the 10-somite stage. /evidence=ECO:0000269|PubMed:19216761, ECO:0000269|PubMed:22216300, ECO:0000269|PubMed:22406073	1..46		14/52 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..43		14/49 (29%)
		Homeodomain	127..183	CDD:459649	28/55 (51%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	206..257