Protein Alignment vnd and NKX2-2

DIOPT Version :9

• Sequence 1: NP_476786.2
• Gene: vnd / 31003
• FlyBaseID: FBgn0261930
• Length: 723
• Species: Drosophila melanogaster
• Sequence 2: NP_002500.1
• Gene: NKX2-2 / 4821
• HGNCID: 7835
• Length: 273
• Species: Homo sapiens
• Alignment Length: 281
• Identity: 117/281 - (41%)
• Similarity: 140/281 - (49%)
• Gaps: 77/281 - (27%)

  Fly   465 GSSGNGSAGGA---PTAHALHNNNNN-------TTNNNNHSLKAEGINGAGSGHDDSLN---EDG 516
            |..|.|:....   |..:..:::::|       :|....:||  .|: .||:...||.:   |..
Human    46 GPLGQGALDAVQSLPLKNPFYDSSDNPYTRWLASTEGLQYSL--HGL-AAGAPPQDSSSKSPEPS 107

  Fly   517 IEEDIDDVDDADGSGGGDANGSDGLPNKKRKRRVLFTKAQTYELERRFRQQRYLSAPEREHLASL 581
            .:|..|:..:..| |||||       .|||||||||:||||||||||||||||||||||||||||
Human   108 ADESPDNDKETPG-GGGDA-------GKKRKRRVLFSKAQTYELERRFRQQRYLSAPEREHLASL 164

  Fly   582 IRLTPTQVKIWFQNHRYKTKRAQNEKGYEGHPGLLHGHATHPHHPSALPSPRRVAVPVLVRNGKP 646
            ||||||||||||||||||.|||:.|||.|..|               ||||||||||||||:|||
Human   165 IRLTPTQVKIWFQNHRYKMKRARAEKGMEVTP---------------LPSPRRVAVPVLVRDGKP 214

  Fly   647 CLGDSSKLGADCVSVSSATATAMQNAAAHHLVALNGAAAYQHAAAAAAGLHAHAHAHAHAHGH-- 709
            |                           |.|.|.:.|||...|....:...|.:..|...:..
Human   215 C---------------------------HALKAQDLAAATFQAGIPFSAYSAQSLQHMQYNAQYS 252

  Fly   710 ---------GHPHAHAQRAAW 721
                     .||...||:..|
Human   253 SASTPQYPTAHPLVQAQQWTW 273

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
vnd	NP_476786.2	Homeobox	548..601	CDD:278475	51/52 (98%)
NKX2-2	NP_002500.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..56		3/9 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	90..131		16/49 (33%)
		Homeobox	131..185	CDD:395001	51/53 (96%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	115	1.000	Domainoid score	I6058
eggNOG	1	0.900	-	-		E2759_KOG0842
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1072653at2759
OrthoFinder	1	1.000	-	-		FOG0002404
OrthoInspector	1	1.000	-	-		oto89156
orthoMCL	1	0.900	-	-		OOG6_108087
Panther	1	1.100	-	-	O	PTHR24340
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2570
SonicParanoid	1	1.000	-	-		X524
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.810