Protein Alignment vnd and NKX1-2

DIOPT Version :10

• Sequence 1: NP_476786.2
• Gene: vnd / 31003
• FlyBaseID: FBgn0261930
• Length: 723
• Species: Drosophila melanogaster
• Sequence 2: NP_001139812.1
• Gene: NKX1-2 / 390010
• HGNCID: 31652
• Length: 310
• Species: Homo sapiens
• Alignment Length: 225
• Identity: 68/225 - (30%)
• Similarity: 77/225 - (34%)
• Gaps: 88/225 - (39%)

  Fly   503 GAGSGHDDSLNEDGIEEDIDDVD---------------------DA------------DGSGG-- 532
            |.|:|....|.....||:.|..|                     ||            ||.||
Human    75 GPGAGQASPLEGSEAEEEEDAEDPRRPRLRERAARLLPGLARSPDAPAGALASGEPCEDGGGGPV 139

  Fly   533 GDANGSDGLPNKKRKR-----------RVLFTKAQTYELERRFRQQRYLSAPEREHLASLIRLTP 586
            ....||.|.|..:|:|           |..||..|...||.:||..||||..||.:||..:.||.
Human   140 RSPPGSPGSPRPRRRRLEPNCAKPRRARTAFTYEQLVALENKFRATRYLSVCERLNLALSLSLTE 204

  Fly   587 TQVKIWFQNHRYKTKRAQN--------------------------EKGYEGHP--GLLHGHATHP 623
            |||||||||.|.|.|: ||                          ..|..|.|  |.|| ..|.|
Human   205 TQVKIWFQNRRTKWKK-QNPGADGAAQVGGGAPQPGAAGGGGGGGSGGSPGPPGTGALH-FQTFP 267

  Fly   624 HH-------PSALPSPRRVAVPVLVRNGKP 646
            .:       |||...|...|.|     |.|
Human   268 SYSAANVLFPSAASFPLTAAAP-----GSP 292

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
vnd	NP_476786.2	Homeodomain	546..602	CDD:459649	31/66 (47%)
NKX1-2	NP_001139812.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	36..165		20/89 (22%)
		Homeodomain	164..220	CDD:459649	29/55 (53%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	217..260		7/43 (16%)