DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vnd and Nkx2-2

DIOPT Version :9

Sequence 1:	NP_476786.2	Gene:	vnd / 31003	FlyBaseID:	FBgn0261930	Length:	723	Species:	Drosophila melanogaster
Sequence 2:	NP_001178833.1	Gene:	Nkx2-2 / 366214	RGDID:	1308443	Length:	273	Species:	Rattus norvegicus

Alignment Length:	277	Identity:	114/277 - (41%)
Similarity:	135/277 - (48%)	Gaps:	72/277 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   465 GSSGNGSAGGAPTAHALHNNNNN-------TTNNNNHSLKAEGINGAGSGHDDSLN--EDGIEED 520
            |.|...:....|.....:::::|       :|....:||  .|:..:....|.|..  |...:|.
  Rat    49 GQSALDAVQSLPLKSPFYDSSDNPYTRWLASTEGLQYSL--HGLAASAPPQDSSSKSPEPSADES 111

  Fly   521 IDDVDDADGSGGGDANGSDGLPNKKRKRRVLFTKAQTYELERRFRQQRYLSAPEREHLASLIRLT 585
            .|:..:..| |||||       .|||||||||:||||||||||||||||||||||||||||||||
  Rat   112 PDNDKETQG-GGGDA-------GKKRKRRVLFSKAQTYELERRFRQQRYLSAPEREHLASLIRLT 168

  Fly   586 PTQVKIWFQNHRYKTKRAQNEKGYEGHPGLLHGHATHPHHPSALPSPRRVAVPVLVRNGKPCLGD 650
            ||||||||||||||.|||:.|||.|..|               ||||||||||||||:||||
  Rat   169 PTQVKIWFQNHRYKMKRARAEKGMEVTP---------------LPSPRRVAVPVLVRDGKPC--- 215

  Fly   651 SSKLGADCVSVSSATATAMQNAAAHHLVALNGAAAYQHAAAAAAGLHAHAHAHAHAHGH------ 709
                                    |.|.|.:.|||...|....:...|.:..|...:..
  Rat   216 ------------------------HALKAQDLAAATFQAGIPFSAYSAQSLQHMQYNAQYSSAST 256

  Fly   710 -----GHPHAHAQRAAW 721
                 .||...||:..|
  Rat   257 PQYPTAHPLVQAQQWTW 273

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vnd	NP_476786.2	Homeobox	548..601	CDD:278475	51/52 (98%)
Nkx2-2	NP_001178833.1	Homeobox	131..185	CDD:395001	51/53 (96%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	115	1.000	Domainoid score	I5895
eggNOG	1	0.900	-	-		E2759_KOG0842
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1072653at2759
OrthoFinder	1	1.000	-	-		FOG0002404
OrthoInspector	1	1.000	-	-		oto96283
orthoMCL	1	0.900	-	-		OOG6_108087
Panther	1	1.100	-	-	O	PTHR24340
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X524
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.780