DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vnd and nkx2.2a

DIOPT Version :9

Sequence 1:	NP_476786.2	Gene:	vnd / 31003	FlyBaseID:	FBgn0261930	Length:	723	Species:	Drosophila melanogaster
Sequence 2:	NP_001295569.1	Gene:	nkx2.2a / 30697	ZFINID:	ZDB-GENE-980526-403	Length:	273	Species:	Danio rerio

Alignment Length:	229	Identity:	110/229 - (48%)
Similarity:	132/229 - (57%)	Gaps:	51/229 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   476 PTAHALHNNNNN-------TTNNNNHSLKAEGINGAGSGHDDSLNEDGIEEDIDDVDDADGSGGG 533
            |..:..::|::|       ||::..:||     :|..:...|: :....|...|:..|.|..  .
Zfish    63 PLKNPFYDNSDNPYTRWLATTDSIQYSL-----HGLSANSQDT-SAKSPEPSADESPDNDKE--T 119

  Fly   534 DANGSDGLPNKKRKRRVLFTKAQTYELERRFRQQRYLSAPEREHLASLIRLTPTQVKIWFQNHRY 598
            .:||||.  .|||||||||:|||||||||||||||||||||||||||||||||||||||||||||
Zfish   120 SSNGSDS--GKKRKRRVLFSKAQTYELERRFRQQRYLSAPEREHLASLIRLTPTQVKIWFQNHRY 182

  Fly   599 KTKRAQNEKGYEGHPGLLHGHATHPHHPSALPSPRRVAVPVLVRNGKPC-------LGDSSKLGA 656
            |.|||:.|||.|         .||      ||||||||||||||:||||       |..:.:.|.
Zfish   183 KMKRARAEKGME---------VTH------LPSPRRVAVPVLVRDGKPCHTLKAQDLAATFQAGI 232

  Fly   657 DCVSVSS------------ATATAMQNAAAHHLV 678
            ...:.|:            :.||..|...|||||
Zfish   233 PFSAYSAQSLQHMQYNAHYSAATTPQFPTAHHLV 266

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vnd	NP_476786.2	Homeobox	548..601	CDD:278475	51/52 (98%)
nkx2.2a	NP_001295569.1	COG5576	93..218	CDD:227863	91/144 (63%)
nkx2.2a	NP_001295569.1	Homeobox	132..185	CDD:278475	51/52 (98%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	115	1.000	Domainoid score	I6005
eggNOG	1	0.900	-	-		E2759_KOG0842
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1072653at2759
OrthoFinder	1	1.000	-	-		FOG0002404
OrthoInspector	1	1.000	-	-		otm25708
orthoMCL	1	0.900	-	-		OOG6_108087
Panther	1	1.100	-	-	LDO	PTHR24340
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2570
SonicParanoid	1	1.000	-	-		X524
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.810