Protein Alignment vnd and GBX1

DIOPT Version :10

• Sequence 1: NP_476786.2
• Gene: vnd / 31003
• FlyBaseID: FBgn0261930
• Length: 723
• Species: Drosophila melanogaster
• Sequence 2: NP_001092304.1
• Gene: GBX1 / 2636
• HGNCID: 4185
• Length: 363
• Species: Homo sapiens
• Alignment Length: 402
• Identity: 111/402 - (27%)
• Similarity: 143/402 - (35%)
• Gaps: 121/402 - (30%)

  Fly   259 AGVSADEHHNGSGTGGGAGEADHHSTTEHHAPPSHPQQQHPHHQQH-----HHPHLLLPQQHHQQ 318
            ||..:....||.|.|||.|.|  .|......||. |:..|..:..:     :.| |:|||   ..
Human     4 AGGGSAPGGNGGGGGGGPGTA--FSIDSLIGPPP-PRSGHLLYTGYPMFMPYRP-LVLPQ---AL 61

  Fly   319 AVAPL-----PLAHHQS-------------GEAQSHAHANAAAAHLLAS--------HNAAAAAA 357
            |.|||     |||...|             |:|.....|...|....|.        ...|||||
Human    62 APAPLPAGLPPLAPLASFAGRLTNTFCAGLGQAVPSMVALTTALPSFAEPPDAFYGPQELAAAAA 126

  Fly   358 VAAGQYLPNLPKNFPGSFGDEMSSYHHMAQTMLQHSGR--SAWIKENELYGTQQPAS--PDSTSP 418
            .||.....|.|:  ||                    ||  ...::.:||...::..:  |....|
Human   127 AAAATAARNNPE--PG--------------------GRRPEGGLEADELLPAREKVAEPPPPPPP 169

  Fly   419 VTSEVSYTYIGSNCQTSPALSGDYKSYSRSADSDALSVGDALHTLHGSSGNG----------SAG 473
            ..||           |.|:|..:.|.||...:....|.||...:.....|:|          |:.
Human   170 HFSE-----------TFPSLPAEGKVYSSDEEKLEASAGDPAGSEQEEEGSGGDSEDDGFLDSSA 223

  Fly   474 GAPTAHALHNNNNNTTNNNNHSLKAEGINGAGSGHDDSLNEDGIEEDIDDVDDADGSGGGDANGS 538
            |.|.|..            ....|.:|..|.|:       |:|          |..:.|..|.|
Human   224 GGPGALL------------GPKPKLKGSLGTGA-------EEG----------APVTAGVTAPG- 258

  Fly   539 DGLPNKKRKRRVLFTKAQTYELERRFRQQRYLSAPEREHLASLIRLTPTQVKIWFQNHRYKTKR- 602
                .|.|:||..||..|..|||:.|..::|||..||..:|..::|:..||||||||.|.|.||
Human   259 ----GKSRRRRTAFTSEQLLELEKEFHCKKYLSLTERSQIAHALKLSEVQVKIWFQNRRAKWKRI 319

  Fly   603 -AQNEKGYEGHP 613
             |.|.....|.|
Human   320 KAGNVSSRSGEP 331

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
vnd	NP_476786.2	Homeodomain	546..602	CDD:459649	27/55 (49%)
GBX1	NP_001092304.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..31		11/28 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	128..265		41/203 (20%)
		Homeodomain	262..318	CDD:459649	27/55 (49%)