Protein Alignment vnd and EN1

DIOPT Version :10

• Sequence 1: NP_476786.2
• Gene: vnd / 31003
• FlyBaseID: FBgn0261930
• Length: 723
• Species: Drosophila melanogaster
• Sequence 2: NP_001417.3
• Gene: EN1 / 2019
• HGNCID: 3342
• Length: 392
• Species: Homo sapiens
• Alignment Length: 419
• Identity: 99/419 - (23%)
• Similarity: 140/419 - (33%)
• Gaps: 113/419 - (26%)

  Fly   252 SALSPTPAGVSADEHHNGSGTGGGAGEADHHSTTEHHAPPSHPQ-------QQHPHHQQHHHPHL 309
            :|.:.||.|:|.......||:.|...:.|....:...||||.|.       ..|||...|..|.
Human    18 AAAAATPGGLSLSLSPGASGSSGSGSDGDSVPVSPQPAPPSPPAAPCLPPLAHHPHLPPHPPPP- 81

  Fly   310 LLPQQHHQQAVAPLPLAHHQSGEAQSHAHANAAAAHLLASH-------------NAAAAAAVAAG 361
              |.||   ..||   ||.....||.|...|....::|...             .||||...|.|
Human    82 --PPQH---LAAP---AHQPQPAAQLHRTTNFFIDNILRPDFGCKKEQPPPQLLVAAAARGGAGG 138

  Fly   362 QYLPNLPKNFPGSFGDEMSSYHHMAQTMLQHSGRSAWIKENELYGTQQPAS-------------P 413
                          |..:.  ....||.   :||.    .....||:.|.:             |
Human   139 --------------GGRVE--RDRGQTA---AGRD----PVHPLGTRAPGAASLLCAPDANCGPP 180

  Fly   414 DSTSPVTSEVSYTYIGSNCQTSPALSGDYKSYSRSADSDALSVGDALHTLHGSSGNGSAGGAPTA 478
            |.:.|..:....:..|:....:.|.:.   :.:.:|.:.|....|.     |..|:|...|:|.|
Human   181 DGSQPAAAGAGASKAGNPAAAAAAAAA---AVAAAAAAAAAKPSDT-----GGGGSGGGAGSPGA 237

  Fly   479 HALHNNNNNTTNNNNHSLKAEGINGAGSGHDDSLNEDG--IEEDIDD------------VDDADG 529
            ..        |....|...|..:.|:.:|        |  ::.|...            ..|...
Human   238 QG--------TKYPEHGNPAILLMGSANG--------GPVVKTDSQQPLVWPAWVYCTRYSDRPS 286

  Fly   530 SGGGDANGSDGLPNKKRKR-RVLFTKAQTYELERRFRQQRYLSAPEREHLASLIRLTPTQVKIWF 593
            ||............|:.|| |..||..|...|:..|:..||::...|:.||..:.|..:|:||||
Human   287 SGPRTRKLKKKKNEKEDKRPRTAFTAEQLQRLKAEFQANRYITEQRRQTLAQELSLNESQIKIWF 351

  Fly   594 QNHRYKTKRAQNEKGYEGHPGLLHGHATH 622
            ||.|.|.|:|         .|:.:|.|.|
Human   352 QNKRAKIKKA---------TGIKNGLALH 371

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
vnd	NP_476786.2	Homeodomain	546..602	CDD:459649	23/56 (41%)
EN1	NP_001417.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..100		28/90 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	132..164		10/54 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	219..251		10/44 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	282..306		5/23 (22%)
		Homeodomain	305..360	CDD:459649	22/54 (41%)
		Engrail_1_C_sig	361..391	CDD:431338	5/20 (25%)