DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Appl and TFPI2

DIOPT Version :9

Sequence 1:	NP_001245448.1	Gene:	Appl / 31002	FlyBaseID:	FBgn0000108	Length:	890	Species:	Drosophila melanogaster
Sequence 2:	NP_006519.1	Gene:	TFPI2 / 7980	HGNCID:	11761	Length:	235	Species:	Homo sapiens

Alignment Length:	141	Identity:	31/141 - (21%)
Similarity:	51/141 - (36%)	Gaps:	32/141 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   462 RFQTSVQALEEEGNAEKH--QLAAM----------HQQRVLAHINQRKREAMTCYTQALTEQPPN 514
            |.|.||.. :.||:.||:  .|::|          |:.|    |..|..:..||......::.|:
Human    97 RLQVSVDD-QCEGSTEKYFFNLSSMTCEKFFSGGCHRNR----IENRFPDEATCMGFCAPKKIPS 156

  Fly   515 AHHVEK----CLQKLLRALHKDRAHALAHYRHLLNSGGPGGLEAAASERPRTLERLIDIDRAVNQ 575
            ..:..|    |...:.|.....|......:.:.    |.||.:.....|.       |..||..:
Human   157 FCYSPKDEGLCSANVTRYYFNPRYRTCDAFTYT----GCGGNDNNFVSRE-------DCKRACAK 210

  Fly   576 SMTMLKRYPEL 586
            ::...|:.|:|
Human   211 ALKKKKKMPKL 221

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Appl	NP_001245448.1	A4_EXTRA	26..198	CDD:128326
		APP_N	33..141	CDD:280358
		APP_Cu_bd	143..198	CDD:289676
		APP_E2	387..580	CDD:289677	28/133 (21%)
		GBP_C	<629..682	CDD:303769
		APP_amyloid	834..887	CDD:287486
TFPI2	NP_006519.1	KU	34..86	CDD:238057
		Kunitz_BPTI	95..149	CDD:278443	16/56 (29%)
		Kunitz_BPTI	157..204	CDD:278443	8/57 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4295
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900