DRSC/TRiP Functional Genomics Resources

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Protein Alignment Appl and spint1b

DIOPT Version :9

Sequence 1:NP_001245448.1 Gene:Appl / 31002 FlyBaseID:FBgn0000108 Length:890 Species:Drosophila melanogaster
Sequence 2:NP_001104693.1 Gene:spint1b / 797346 ZFINID:ZDB-GENE-071218-1 Length:499 Species:Danio rerio


Alignment Length:517 Identity:80/517 - (15%)
Similarity:149/517 - (28%) Gaps:229/517 - (44%)


- Green bases have known domain annotations that are detailed below.


  Fly    83 KAYPNRDITNIVESSHYQKIGGWCRQGALNAAKCKGSHRWIKPFRCLGPFQSDALLVPEGCLFDH 147
            |..|.:..||.:.||.|:|.        |:..|.:|...  .|....|   .|.::.|..   |.
Zfish   107 KFTPKQGFTNYILSSVYEKY--------LSGRKSEGKDS--PPIANAG---RDVVVQPNE---DV 155

  Fly   148 IHNASRCWP-----FVRWNQTGAAACQERGMQMRSFAMLLPCGISVFSGVEFVCCPKHFKTDEIH 207
            :.|.:..|.     ...|:.|       ||                              ...:|
Zfish   156 LLNGNESWDDKEIVNYEWSLT-------RG------------------------------NKSVH 183

  Fly   208 VKKTDLPVMPAAQINSAN-------DELVMNDEDDSNDS-------------------------- 239
            ::||:.    ..||..:|       .:|.:.|..|.:||                          
Zfish   184 MEKTNF----RDQIRVSNLIPGVYEFKLTVTDSADQSDSAQVIVLVLTSEQSERHCLTPKKTGPC 244

  Fly   240 -------NYSKDANEDD-------LDDEDDLMGDDEEDDMVADEAATAGG-----------SPNT 279
                   ||:..:...:       :::.::.:.:.|..:...:....|||           ||..
Zfish   245 RASFIRWNYNAASRRCEQFIFGGCMENSNNYLSETECQNACENTTVRAGGVTRKVPVEDCSSPCG 309

  Fly   280 GSSGDSNSGSLDDINAEYDSGEEGDNYEE--DGAGSESEAEVEASWDQSGGAKVVSLKSDSSSPS 342
            ..|...:||..  :..|:    |.|.::|  ||:..::..::..|.     .::::::.:..:..
Zfish   310 VDSFKCSSGCC--VKKEF----ECDGHQECSDGSDEKNCQQLNESL-----TRLLNIEVNKKAHC 363

  Fly   343 SAPVAPAPEKAPVKSESVTSTPQLSASAAAFVAANSGNSGTGAGAPPSTAQPTSDPYFTHFDPHY 407
            :.|.|..|.:|                                                    |:
Zfish   364 TDPPATGPCRA----------------------------------------------------HF 376

  Fly   408 EHQSYKVSQKRL----------EESHREKVTRVMKDWSDLEEKYQDMRLADPKAAQSFKQRMTAR 462
            .|..|....|:.          ..::.|...:.||:.|.:.:|            ..|.:.:..|
Zfish   377 HHWYYDPLSKKCHSFTYGGCDGNRNNFETADKCMKNCSGVTDK------------DVFARGLLVR 429

  Fly   463 FQTSVQALEEEGNAEKHQLA-----AMHQQRVLAHI------NQRKREAMTCYTQALTEQPP 513
            .       ||.|.::...:|     |:....|||.:      |:||.:    :.:..|..||
Zfish   430 G-------EELGESQSASVALAVVLAVAILAVLAVLGYFYLKNRRKHQ----HQRVATSNPP 480

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ApplNP_001245448.1 A4_EXTRA 26..198 CDD:128326 22/119 (18%)
APP_N 33..141 CDD:280358 14/57 (25%)
APP_Cu_bd 143..198 CDD:289676 7/59 (12%)
APP_E2 387..580 CDD:289677 25/148 (17%)
GBP_C <629..682 CDD:303769
APP_amyloid 834..887 CDD:287486
spint1bNP_001104693.1 MANEC 31..116 CDD:284837 2/8 (25%)
PKD 148..225 CDD:214510 19/120 (16%)
Kunitz_BPTI 235..285 CDD:278443 3/49 (6%)
LDLa 308..342 CDD:238060 9/39 (23%)
Kunitz_BPTI 363..413 CDD:278443 11/101 (11%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4295
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

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