Protein Alignment Appl and aplp2

DIOPT Version :10

• Sequence 1: NP_001245448.1
• Gene: Appl / 31002
• FlyBaseID: FBgn0000108
• Length: 890
• Species: Drosophila melanogaster
• Sequence 2: XP_005159308.1
• Gene: aplp2 / 796801
• ZFINID: ZDB-GENE-061009-28
• Length: 776
• Species: Danio rerio
• Alignment Length: 911
• Identity: 242/911 - (26%)
• Similarity: 372/911 - (40%)
• Gaps: 232/911 - (25%)

  Fly    33 EPQIAVLCEAGQIYQPQYLSEEGRWVTDLSKKTTGPTCLRDKMDLLDYCKKAYPNRDITNIVESS 97
            |||:|:.|  |::.....: :.|||..|.|   ...||:..|..:|.||::.||...|||:||::
Zfish    38 EPQVAMFC--GKLNMHINI-QTGRWEPDPS---GSKTCVGTKEGVLQYCQEIYPELQITNVVEAN 96

  Fly    98 HYQKIGGWCRQGALNAAKCKGSHRWIKPFRCL-GPFQSDALLVPEGCLFDHIHNASRCWPFVRWN 161
            ...||..||::   :..:|||....:.|::|| |.|.||.|||||.|.|.|......|....:|:
Zfish    97 QPVKIENWCKK---DKKQCKGHAHIVVPYKCLVGEFVSDVLLVPEKCKFFHKERMDMCVSHQQWH 158

  Fly   162 QTGAAACQERGMQMRSFAMLLPCGISVFSGVEFVCCPKHFKTDEIHVKKTDLPVMPAAQINSAND 226
            .....||.:..|.:.|:.|||||||..|.|.|:||||.         .:.:.|..||:.....:|
Zfish   159 GVAKEACSKGNMVLHSYGMLLPCGIDKFHGTEYVCCPS---------TRPEEPAPPASPSKEMDD 214

  Fly   227 ELVMNDEDDSNDSNYSKDANEDDLDDEDDLMGDDEEDDMVA-DEAATAGGSPNTGSSGDSNSGSL 290
            |    |:||           |::.|.|:.::.:|||||..| ||:......|.|..
Zfish   215 E----DDDD-----------EEEEDVEEPVVEEDEEDDEDAVDESEPVAIDPPTQE--------- 255

  Fly   291 DDINAEYDSGEEGDN------YEEDGAGSESEAEVEASWDQSGGAKVVSLKSDSS---SPSSAPV 346
            |....|.:..|:||.      ||::....:||.:     |......|:..|.|..   ....|..
Zfish   256 DTAEEEEEQEEDGDEEDYHYIYEDEEEDRDSEEK-----DVKKEKAVMPEKQDDDKTLQEVEAVC 315

  Fly   347 APAPEKAPVKSESVTSTPQ-----LSASAAAFV----AANSGNSGT---------GAGAPPSTAQ 393
            :...|..|.::    |.|:     .......|:    |.|..|..:         ....|| |.|
Zfish   316 SLEAETGPCRA----SMPRWHFDMQQRKCVRFIYGGCAGNRNNFDSEEYCMVVCKRLTVPP-TPQ 375

  Fly   394 PTS--DPYFTHFDPHYEHQSYKVSQKRLEESHREKVTRVMKDWSDLEEKYQDMRLADPKAAQSFK 456
            ||.  |.||.......||..::.::::||..||.::.||.|:|.:.|.:.:::    |||.   :
Zfish   376 PTDDVDVYFETPADDKEHSRFQKAKEQLEIRHRNRMERVRKEWEEAESQARNL----PKAE---R 433

  Fly   457 QRMTARFQTSVQALEEEGNAEKHQLAAMHQQRVLAHINQRKREAMTCYTQALTEQPPNAHHVEKC 521
            |.:...||..|::||||..:||.||...|..||.|.:|.|:|.|:..|..||...||..|.:.:.
Zfish   434 QTLIQHFQAMVESLEEEAASEKQQLVETHLARVEAMLNDRRRLALENYLAALQADPPRPHRILQA 498

  Fly   522 LQKLLRALHKDRAHALAHYRHLLNSGGPGGLEAAASERPRTLERLIDIDRAVNQSMTMLKRYPEL 586
            |::.:||.:|||.|.:.||:|:| :..|   |.||..:.:.:..|..|:..:|||:::|.:.|.:
Zfish   499 LKRYVRAENKDRQHTIRHYQHVL-AVDP---EKAAQMKSQVMTHLRVIEERMNQSLSLLYKVPYV 559

  Fly   587 SAKIAQLMNDYILALRSKDDIPGSSLGMSEEAEAGILDKYRVEIERKVAEKERLRLAEKQRKEQR 651
            :.:|             :|:|
Zfish   560 AEEI-------------QDEI-------------------------------------------- 567

  Fly   652 AAEREKLREEKLRLEAKKVDDMLKSQVAEQQSQPTQSSTQSQAQQQQQEKSLPGKELGPDA--AL 714
                    :|.|:::...:|..| |.::|.|...|.||.:|     .:..:..||...|..  :|
Zfish   568 --------DELLQVQKADMDQFL-SSISESQPDVTVSSEES-----VEVPAFEGKPFRPFQVNSL 618

  Fly   715 VTAANPNLETTKSEKDLSDTEY------------GEATVSTKVQTVLPTVDDDAVQRAVEDVAAA 767
            .:.|.|       |.|||:...            |......||......::::.|.....||...
Zfish   619 GSPAEP-------EGDLSEPPRAFKKGSGMNSLDGLIGAEEKVINSKNKINENVVIDETLDVKEV 676

  Fly   768 VAHQEAEPQVQHFMTHDLGHRESSFSLRREFAQHAHAAKEGRNVYFTLSFAGIALMAAVFVGVAV 832
            :.: ..:|....      |..:.||                |.:....||...||:..:.:.||:
Zfish   677 ILN-GVDPLFSR------GSEQESF----------------RPLVDDFSFGSSALIGLLVIAVAI 718

  Fly   833 A-----------KWRTSRSPHAQGFIEVDQVGCQNVTTHHPIVREEKIVPNMQINGYENPTYKYF 886
            |           |.:.....|  |.:|||.:          :..||:.:..||.:|||||||||.
Zfish   719 ATVIVISLVLLRKRQYGTISH--GIVEVDPM----------LTPEERHLSKMQNHGYENPTYKYL 771

  Fly   887 E 887
            |
Zfish   772 E 772

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Appl	NP_001245448.1	A4_EXTRA	26..198	CDD:128326	64/165 (39%)
		APP_E2	388..580	CDD:463752	69/193 (36%)
		DDRGK	632..>682	CDD:370664	6/49 (12%)
		APP_amyloid	834..887	CDD:463129	19/52 (37%)
aplp2	XP_005159308.1	A4_EXTRA	31..195	CDD:128326	64/165 (39%)
		Kunitz_ABPP-like	314..365	CDD:438650	8/54 (15%)
		APP_E2	371..553	CDD:463752	69/193 (36%)
		JMTM_APLP2	693..773	CDD:411992	30/108 (28%)