DRSC/TRiP Functional Genomics Resources

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Protein Alignment Appl and aplp2

DIOPT Version :9

Sequence 1:NP_001245448.1 Gene:Appl / 31002 FlyBaseID:FBgn0000108 Length:890 Species:Drosophila melanogaster
Sequence 2:XP_005159308.1 Gene:aplp2 / 796801 ZFINID:ZDB-GENE-061009-28 Length:776 Species:Danio rerio


Alignment Length:911 Identity:242/911 - (26%)
Similarity:372/911 - (40%) Gaps:232/911 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    33 EPQIAVLCEAGQIYQPQYLSEEGRWVTDLSKKTTGPTCLRDKMDLLDYCKKAYPNRDITNIVESS 97
            |||:|:.|  |::.....: :.|||..|.|   ...||:..|..:|.||::.||...|||:||::
Zfish    38 EPQVAMFC--GKLNMHINI-QTGRWEPDPS---GSKTCVGTKEGVLQYCQEIYPELQITNVVEAN 96

  Fly    98 HYQKIGGWCRQGALNAAKCKGSHRWIKPFRCL-GPFQSDALLVPEGCLFDHIHNASRCWPFVRWN 161
            ...||..||::   :..:|||....:.|::|| |.|.||.|||||.|.|.|......|....:|:
Zfish    97 QPVKIENWCKK---DKKQCKGHAHIVVPYKCLVGEFVSDVLLVPEKCKFFHKERMDMCVSHQQWH 158

  Fly   162 QTGAAACQERGMQMRSFAMLLPCGISVFSGVEFVCCPKHFKTDEIHVKKTDLPVMPAAQINSAND 226
            .....||.:..|.:.|:.|||||||..|.|.|:||||.         .:.:.|..||:.....:|
Zfish   159 GVAKEACSKGNMVLHSYGMLLPCGIDKFHGTEYVCCPS---------TRPEEPAPPASPSKEMDD 214

  Fly   227 ELVMNDEDDSNDSNYSKDANEDDLDDEDDLMGDDEEDDMVA-DEAATAGGSPNTGSSGDSNSGSL 290
            |    |:||           |::.|.|:.::.:|||||..| ||:......|.|..         
Zfish   215 E----DDDD-----------EEEEDVEEPVVEEDEEDDEDAVDESEPVAIDPPTQE--------- 255

  Fly   291 DDINAEYDSGEEGDN------YEEDGAGSESEAEVEASWDQSGGAKVVSLKSDSS---SPSSAPV 346
            |....|.:..|:||.      ||::....:||.:     |......|:..|.|..   ....|..
Zfish   256 DTAEEEEEQEEDGDEEDYHYIYEDEEEDRDSEEK-----DVKKEKAVMPEKQDDDKTLQEVEAVC 315

  Fly   347 APAPEKAPVKSESVTSTPQ-----LSASAAAFV----AANSGNSGT---------GAGAPPSTAQ 393
            :...|..|.::    |.|:     .......|:    |.|..|..:         ....|| |.|
Zfish   316 SLEAETGPCRA----SMPRWHFDMQQRKCVRFIYGGCAGNRNNFDSEEYCMVVCKRLTVPP-TPQ 375

  Fly   394 PTS--DPYFTHFDPHYEHQSYKVSQKRLEESHREKVTRVMKDWSDLEEKYQDMRLADPKAAQSFK 456
            ||.  |.||.......||..::.::::||..||.::.||.|:|.:.|.:.:::    |||.   :
Zfish   376 PTDDVDVYFETPADDKEHSRFQKAKEQLEIRHRNRMERVRKEWEEAESQARNL----PKAE---R 433

  Fly   457 QRMTARFQTSVQALEEEGNAEKHQLAAMHQQRVLAHINQRKREAMTCYTQALTEQPPNAHHVEKC 521
            |.:...||..|::||||..:||.||...|..||.|.:|.|:|.|:..|..||...||..|.:.:.
Zfish   434 QTLIQHFQAMVESLEEEAASEKQQLVETHLARVEAMLNDRRRLALENYLAALQADPPRPHRILQA 498

  Fly   522 LQKLLRALHKDRAHALAHYRHLLNSGGPGGLEAAASERPRTLERLIDIDRAVNQSMTMLKRYPEL 586
            |::.:||.:|||.|.:.||:|:| :..|   |.||..:.:.:..|..|:..:|||:::|.:.|.:
Zfish   499 LKRYVRAENKDRQHTIRHYQHVL-AVDP---EKAAQMKSQVMTHLRVIEERMNQSLSLLYKVPYV 559

  Fly   587 SAKIAQLMNDYILALRSKDDIPGSSLGMSEEAEAGILDKYRVEIERKVAEKERLRLAEKQRKEQR 651
            :.:|             :|:|                                            
Zfish   560 AEEI-------------QDEI-------------------------------------------- 567

  Fly   652 AAEREKLREEKLRLEAKKVDDMLKSQVAEQQSQPTQSSTQSQAQQQQQEKSLPGKELGPDA--AL 714
                    :|.|:::...:|..| |.::|.|...|.||.:|     .:..:..||...|..  :|
Zfish   568 --------DELLQVQKADMDQFL-SSISESQPDVTVSSEES-----VEVPAFEGKPFRPFQVNSL 618

  Fly   715 VTAANPNLETTKSEKDLSDTEY------------GEATVSTKVQTVLPTVDDDAVQRAVEDVAAA 767
            .:.|.|       |.|||:...            |......||......::::.|.....||...
Zfish   619 GSPAEP-------EGDLSEPPRAFKKGSGMNSLDGLIGAEEKVINSKNKINENVVIDETLDVKEV 676

  Fly   768 VAHQEAEPQVQHFMTHDLGHRESSFSLRREFAQHAHAAKEGRNVYFTLSFAGIALMAAVFVGVAV 832
            :.: ..:|....      |..:.||                |.:....||...||:..:.:.||:
Zfish   677 ILN-GVDPLFSR------GSEQESF----------------RPLVDDFSFGSSALIGLLVIAVAI 718

  Fly   833 A-----------KWRTSRSPHAQGFIEVDQVGCQNVTTHHPIVREEKIVPNMQINGYENPTYKYF 886
            |           |.:.....|  |.:|||.:          :..||:.:..||.:|||||||||.
Zfish   719 ATVIVISLVLLRKRQYGTISH--GIVEVDPM----------LTPEERHLSKMQNHGYENPTYKYL 771

  Fly   887 E 887
            |
Zfish   772 E 772

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ApplNP_001245448.1 A4_EXTRA 26..198 CDD:128326 64/165 (39%)
APP_N 33..141 CDD:280358 41/108 (38%)
APP_Cu_bd 143..198 CDD:289676 21/54 (39%)
APP_E2 387..580 CDD:289677 69/194 (36%)
GBP_C <629..682 CDD:303769 6/52 (12%)
APP_amyloid 834..887 CDD:287486 19/52 (37%)
aplp2XP_005159308.1 A4_EXTRA 31..195 CDD:128326 64/165 (39%)
APP_N 38..138 CDD:280358 41/108 (38%)
APP_Cu_bd 140..195 CDD:289676 21/54 (39%)
Kunitz_BPTI 314..366 CDD:278443 8/55 (15%)
APP_E2 371..553 CDD:289677 69/193 (36%)
APP_amyloid 722..772 CDD:287486 19/61 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170589116
Domainoid 1 1.000 113 1.000 Domainoid score I6081
eggNOG 1 0.900 - - E1_KOG4295
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 260 1.000 Inparanoid score I3103
OMA 1 1.010 - - QHG50020
OrthoDB 1 1.010 - - D405630at33208
OrthoFinder 1 1.000 - - FOG0001588
OrthoInspector 1 1.000 - - otm25078
orthoMCL 1 0.900 - - OOG6_104222
Panther 1 1.100 - - O PTHR23103
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2378
SonicParanoid 1 1.000 - - X996
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
ZFIN 00.000 Not matched by this tool.
1514.890

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