Protein Alignment Appl and Eppin

DIOPT Version :10

• Sequence 1: NP_001245448.1
• Gene: Appl / 31002
• FlyBaseID: FBgn0000108
• Length: 890
• Species: Drosophila melanogaster
• Sequence 2: NP_001102927.1
• Gene: Eppin / 685161
• RGDID: 1597722
• Length: 134
• Species: Rattus norvegicus
• Alignment Length: 143
• Identity: 31/143 - (21%)
• Similarity: 50/143 - (34%)
• Gaps: 46/143 - (32%)

  Fly    13 SLWVVLAIGTAQVQAAS------PRWEPQIAVLCEAGQIYQPQYLSEEGRWVTDLSKK------T 65
            |:.|:..:.| :||..|      ||..|:....||    ::.:.|....|   |..|:      :
  Rat     8 SILVLFGLLT-KVQGPSLTDFLFPRRCPRFREECE----HRERDLCTRDR---DCQKREKCCIFS 64

  Fly    66 TGPTCLRDKMDLLD------YCKKAYPNRDITNIVESSHYQKIGGWCRQGALNAAKCKGSHRWIK 124
            .|..||..:.|:..      ||...:|.         ..|.|..|.|:......  |:|::
  Rat    65 CGKKCLNPQQDICSLPKDSGYCMAYFPR---------WWYNKKNGTCQLFIYGG--CQGNN---- 114

  Fly   125 PFRCLGPFQSDAL 137
                 ..|||.::
  Rat   115 -----NNFQSQSI 122

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Appl	NP_001245448.1	A4_EXTRA	26..198	CDD:128326	27/130 (21%)
		APP_E2	388..580	CDD:463752
		DDRGK	632..>682	CDD:370664
		APP_amyloid	834..887	CDD:463129
Eppin	NP_001102927.1	WAP	30..72	CDD:459672	12/48 (25%)
		Kunitz_eppin	75..131	CDD:438654	13/68 (19%)
		Interaction with SEMG1. /evidence=ECO:0000250	102..133		6/32 (19%)
		Interaction with LTF. /evidence=ECO:0000250	117..133		3/6 (50%)