DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Appl and SPINT1

DIOPT Version :9

Sequence 1:	NP_001245448.1	Gene:	Appl / 31002	FlyBaseID:	FBgn0000108	Length:	890	Species:	Drosophila melanogaster
Sequence 2:	NP_001373802.1	Gene:	SPINT1 / 6692	HGNCID:	11246	Length:	529	Species:	Homo sapiens

Alignment Length:	193	Identity:	42/193 - (21%)
Similarity:	62/193 - (32%)	Gaps:	71/193 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 VTDLSKKTTGPTCLRDKMDLLDYCKKAYPN--RDIT-NIVESSHYQKIGGWC---RQGALNAAKC 116
            ||.||.|.|...||..  :.:..|:.::|.  .|.| .|.:|..|    |.|   :...|...:|
Human   238 VTVLSTKQTEDYCLAS--NKVGRCRGSFPRWYYDPTEQICKSFVY----GGCLGNKNNYLREEEC 296

  Fly   117 KGSHRWIK--PFR---------------------CLGPFQSDALLVPEGCLFDHIHNASRCWPFV 158
            ..:.|.::  |.|                     |.|..|........||..|         .|:
Human   297 ILACRGVQGGPLRGSSGAQATFPQGPSMERRHPVCSGTCQPTQFRCSNGCCID---------SFL 352

  Fly   159 RWNQT-------GAAACQERGMQMRSFAMLLPCGISVFSGVEFVCCPKHFKTDEIHVKKTDLP 214
            ..:.|       ..|||::.              .|.|..::.:    ||.:|:.|.  .|||
Human   353 ECDDTPNCPDASDEAACEKY--------------TSGFDELQRI----HFPSDKGHC--VDLP 395

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Appl	NP_001245448.1	A4_EXTRA	26..198	CDD:128326	35/175 (20%)
		APP_N	33..141	CDD:280358	25/111 (23%)
		APP_Cu_bd	143..198	CDD:289676	9/61 (15%)
		APP_E2	387..580	CDD:289677
		GBP_C	<629..682	CDD:303769
		APP_amyloid	834..887	CDD:287486
SPINT1	NP_001373802.1	MANEC	50..139	CDD:400058
		Kunitz_BPTI	249..301	CDD:394972	13/57 (23%)
		LDLa	334..366	CDD:197566	6/40 (15%)
		Kunitz_BPTI	391..442	CDD:394972	3/7 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4295
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900