DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Appl and HHIP

DIOPT Version :9

Sequence 1:NP_001245448.1 Gene:Appl / 31002 FlyBaseID:FBgn0000108 Length:890 Species:Drosophila melanogaster
Sequence 2:NP_071920.1 Gene:HHIP / 64399 HGNCID:14866 Length:700 Species:Homo sapiens


Alignment Length:171 Identity:34/171 - (19%)
Similarity:55/171 - (32%) Gaps:74/171 - (43%)


- Green bases have known domain annotations that are detailed below.


  Fly    63 KKTTGPTC-LRDKMDLLDYCKKAYPNRDITNIVESSHYQKIGGWCRQ----------GALNAAKC 116
            |:..||.. ..|:|:..|            .:.|.|...|...:|.|          |||::.  
Human   186 KQVRGPASNYLDQMEEYD------------KVEEISRKHKHNCFCIQEVVSGLRQPVGALHSG-- 236

  Fly   117 KGSHR--------WIKPFRCLGPFQSDALLVPEGCLFDHIHNASRCWPFV---RWNQTGAAACQE 170
            .||.|        ::|            :|.|||.:|..        |::   :..|:|.....|
Human   237 DGSQRLFILEKEGYVK------------ILTPEGEIFKE--------PYLDIHKLVQSGIKGGDE 281

  Fly   171 RGMQMRSFAMLLPCGISVFSGVEFVCCPKHFKTDEIHVKKT 211
            ||:...:|.                  |.:.|..:::|..|
Human   282 RGLLSLAFH------------------PNYKKNGKLYVSYT 304

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ApplNP_001245448.1 A4_EXTRA 26..198 CDD:128326 30/156 (19%)
APP_N 33..141 CDD:280358 19/96 (20%)
APP_Cu_bd 143..198 CDD:289676 8/57 (14%)
APP_E2 387..580 CDD:289677
GBP_C <629..682 CDD:303769
APP_amyloid 834..887 CDD:287486
HHIPNP_071920.1 Folate_rec 38..220 CDD:281076 10/45 (22%)
GSDH 226..>428 CDD:285269 23/119 (19%)
Interaction with SHH zinc binding site 376..388
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4295
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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