DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Appl and Aplp2

DIOPT Version :9

Sequence 1:	NP_001245448.1	Gene:	Appl / 31002	FlyBaseID:	FBgn0000108	Length:	890	Species:	Drosophila melanogaster
Sequence 2:	NP_037038.1	Gene:	Aplp2 / 64312	RGDID:	2128	Length:	765	Species:	Rattus norvegicus

Alignment Length:	937	Identity:	241/937 - (25%)
Similarity:	379/937 - (40%)	Gaps:	253/937 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LWVVLAIGTAQVQAASPRW---------------EPQIAVLCEAGQIYQPQYLSEEGRWVTDLSK 63
            |.|:|.:|.....||...:               |||||:.|  |::.....: :.|:|..|
  Rat    15 LLVLLLLGLTAPAAALAGYIEALAANAGTGFAVAEPQIAMFC--GKLNMHVNI-QTGKWEPD--- 73

  Fly    64 KTTGPTCLRDKMDLLDYCKKAYPNRDITNIVESSHYQKIGGWCRQGALNAAKCKGSHRWIKPFRC 128
            .|...:||..|.::|.||::.||...|||::|::....|..|||:   :..:|: ||..| ||:|
  Rat    74 PTGTKSCLGTKEEVLQYCQEIYPELQITNVMEANQPVNIDSWCRR---DKKQCR-SHIVI-PFKC 133

  Fly   129 L-GPFQSDALLVPEGCLFDHIHNASRCWPFVRWNQTGAAACQERGMQMRSFAMLLPCGISVFSGV 192
            | |.|.||.|||||.|.|.|......|....||:.....||...||.:.|:.||||||:..|.|.
  Rat   134 LVGEFVSDVLLVPENCQFFHQERMEVCEKHQRWHTVVKEACLTEGMTLYSYGMLLPCGVDQFHGT 198

  Fly   193 EFVCCPKHFKTDEIHVKKTDLPVMPAAQINSANDELVMNDEDDSNDSNYSKDAN----EDDLDDE 253
            |:||||:             ..|:.:....|..:|   .:|::..:.:|:.|.:    |.||:|.
  Rat   199 EYVCCPQ-------------TKVVDSDSTMSKEEE---EEEEEDEEEDYALDKSEFPTEADLEDF 247

  Fly   254 DDLMGDDEEDDMVADEAATAGGSPNTGSSGDSNSGSLDDINAEYDSGEEGDNYEEDGA------G 312
            .:...|::||:...:|              :.....::|.:..||| .:||:|.|:..      |
  Rat   248 TEAAADEDEDEEEEEE--------------EEGEEVVEDRDYYYDS-FKGDDYNEENPTEPSSDG 297

  Fly   313 SESEAEVEASWDQSGGAKVVSLKSDSSSPSSAPVAPAPEKAPVKSESVTSTPQLSASAAAFVAAN 377
            :.|:.|:      :...|.|..:...:.|..| |.|.......|.:.|           .|:...
  Rat   298 TISDKEI------AHDVKAVCSQEAMTGPCRA-VMPRWYFDLSKGKCV-----------RFIYGG 344

  Fly   378 SGNSGTGAGAP-----------PSTAQPTS--DPYFTHFDPHYEHQSYKVSQKRLEESHREKVTR 429
            .|.:.....:.           |.|..||:  |.||.......||..::.::::||..||.::.|
  Rat   345 CGGNRNNFESEDYCMAVCKTMIPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRSRMDR 409

  Fly   430 VMKDWSDLEEKYQDMRLADPKAAQSFKQRMTARFQTSVQALEEEGNAEKHQLAAMHQQRVLAHIN 494
            |.|:|.:.|.:.:::    |||.   :|.:...||..|:|||:|..:||.||...|..||.|.:|
  Rat   410 VKKEWEEAELQAKNL----PKAE---RQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLN 467

  Fly   495 QRKREAMTCYTQALTEQPPNAHHVEKCLQKLLRALHKDRAHALAHYRHLLNSGGPGGLEAAASER 559
            .|:|.|:..|..||...||..|.:.:.|::.:||.:|||.|.:.||:|:| :..|   |.||..:
  Rat   468 DRRRIALENYLAALQSDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVL-AVDP---EKAAQMK 528

  Fly   560 PRTLERLIDIDRAVNQSMTMLKRYPELSAKIAQLMNDYILALRSKDDIPGSSLGMSEEAEAGILD 624
            .:.:..|..|:...|||:::|.:.|    .:||
  Rat   529 SQVMTHLHVIEERRNQSLSLLYKVP----YVAQ-------------------------------- 557

  Fly   625 KYRVEIERKVAEKERLRLAEKQRKEQRAAEREKLREEKLRLEAKKVDDMLKSQVAEQQSQPTQSS 689
                ||:.::.|     |.::||.:.                     |...|.::|.......||
  Rat   558 ----EIQEEIDE-----LLQEQRADM---------------------DQFTSSISENPVDVRVSS 592

  Fly   690 TQSQAQQQQQEKSLPGKELGPDAALVTAANPNLET-------TKSEKDLSDTEYGEATVSTKVQT 747
            .:|       |:..|.....|..:|    :.|.:|       .|....:::.:.|......||..
  Rat   593 EES-------EEIPPFHPFHPFPSL----SENEDTQPELYHPMKKGSGMAEQDGGLIGAEEKVIN 646

  Fly   748 VLPTVDDDAVQRAVEDV------AAAVAHQEAEPQVQHFMTHDLGHRESSFSLRREFAQHAHAAK 806
            ....:|::.|.....||      |..|...|.||             :|...||.:|
  Rat   647 SKNKMDENMVIDETLDVKEMIFNAERVGGLEEEP-------------DSVGPLREDF-------- 690

  Fly   807 EGRNVYFTLSFAGIALMAAVFVGVAVA-----------KWRTSRSPHAQGFIEVDQVGCQNVTTH 860
                     |.:..||:..:.:.||:|           |.:.....|  |.:|||.:
  Rat   691 ---------SLSSSALIGLLVIAVAIATVIVISLVMLRKRQYGTISH--GIVEVDPM-------- 736

  Fly   861 HPIVREEKIVPNMQINGYENPTYKYFE 887
              :..||:.:..||.:|||||||||.|
  Rat   737 --LTPEERHLNKMQNHGYENPTYKYLE 761

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Appl	NP_001245448.1	A4_EXTRA	26..198	CDD:128326	68/187 (36%)
		APP_N	33..141	CDD:280358	42/108 (39%)
		APP_Cu_bd	143..198	CDD:289676	22/54 (41%)
		APP_E2	387..580	CDD:289677	67/205 (33%)
		GBP_C	<629..682	CDD:303769	9/52 (17%)
		APP_amyloid	834..887	CDD:287486	19/52 (37%)
Aplp2	NP_037038.1	A4_EXTRA	42..204	CDD:128326	66/172 (38%)
		GFLD subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01217	46..139		36/103 (35%)
		APP_N	49..147	CDD:280358	42/108 (39%)
		CuBD subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01217	147..205		24/57 (42%)
		APP_Cu_bd	149..204	CDD:289676	22/54 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	211..301		22/107 (21%)
		Kunitz_BPTI	311..363	CDD:278443	9/63 (14%)
		APP_E2	367..549	CDD:289677	67/192 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	597..616		4/22 (18%)
		APP_amyloid	711..761	CDD:287486	19/61 (31%)
		Interaction with DAB2. /evidence=ECO:0000250	751..765		10/11 (91%)
		NPXY motif	752..757		4/4 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347496
Domainoid	1	1.000	108	1.000	Domainoid score	I6291
eggNOG	1	0.900	-	-		E1_KOG4295
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	226	1.000	Inparanoid score	I3397
OMA	1	1.010	-	-		QHG50020
OrthoDB	1	1.010	-	-		D405630at33208
OrthoFinder	1	1.000	-	-		FOG0001588
OrthoInspector	1	1.000	-	-		otm45349
orthoMCL	1	0.900	-	-		OOG6_104222
Panther	1	1.100	-	-	O	PTHR23103
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X996
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.900